2006.9-2010.6中南民族大学 生物工程专业 本科

2010.9-2014.12中国科学院水生生物研究所 遗传学专业 硕博连读

2015.2-2018.12 中国科学院水生生物研究所 助理研究员

2018.12-至今 中国科学院水生生物研究所 副研究员

水产养殖（硕士生）

以第一或通讯作者在eLife, Engineering, Genome Res., PLoS Genet., Endocrinology, Aquaculture, Mol. Cell. Biol., Am. J. Physiol.-Endoc. M., Sci. Bull.等SCI源刊发表论文二十余篇。

一、第一或通讯作者论文（1共同第一作者，#通讯作者）：

1.Zhai G1, Shu TT1, Yu GQ, Tang HP, Shi C, Jia JY, Lou QY, Dai XY, Jin X, He JY, Xiao WH, Liu XC, Yin Z#. Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling.eLife2022, 28,11:e66118.

2. Lu LF, Cui BJ, Shi SC, Wang YY, Zhang C, Xu X, Tian MZ, Li ZQ, Xu N, Li ZC, Chen DD, Zhou L,Zhai G#, Yin Z#, Li S#. Male-biased Cyp17a2 governs antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation.eLife2025, 10.7554/eLife.108048.1.

3.Zhai G, Shu TT, Chen KX, Lou QY, Jia JY, Huang JF, Shi C, Jin X, He JY, Jiang DH, Qian XQ, Hu W, Yin Z#. Successful production of an all-female common carp (Cyprinus carpioL.) population usingcyp17a1-deficient neomale carps.Engineering2022, 8(3):181-189.

4. Liu YL1,Zhai G1, Su JZ1, Gong YL, Yang BY, Lu QS, Xi LW, Zheng YT, Cao JY, Liu HK, Jin JY, Zhang ZM, Yang YX, Zhu XM, Wang ZW, Gong GR, Mei J, Yin Z, Gozlan RE, Xie SQ#, Han D#. The genome of Chinese longsnout catfish provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores.Genome Research2024, 34(7):981-996.

5. Ruan YL, Li XH, Wang XY,Zhai G#, Lou QY, Jin X, He JY, Mei J, Xiao WH, Gui JF, Yin Z#. New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis.PLoS Genetics2024, 20(3):e1011170.

6.Zhai G, Shu TT, Xia YG, Lu Y, Shang GH, Jin X, He JY, Nie P, Yin Z#. Characterization of sexual trait development incyp17a1-deficient zebrafish.Endocrinology2018, 159(10):3549-62.

7. Xie YT, Bao HF, Chen GH, Li XH, Ruan YL, Lou QY, Jin X, He JY, Zhang TS, Wang J, Qian XQ,Zhai G#, Yin Z#. A rapid method to generate an all-female population in common carp (Cyprinus carpio) using the neomale carp of F0 population with targeted aromatase mutations.Aquaculture2026, 612:743185.

8. Shi SC1, Wang XY1, Jia JY, Chen GH, Bao HF, Li XH, Lou QY, Yuan QY, He JY, Wang J, Qian XQ, Zhai G#, Yin Z#. Augmentation ofdmrt1leads to gonadal differentiation towards testis incyp17a1−/−;XX common carp.Aquaculture2026, In press.

9. Jia JY, Chen GH, Shu TT, Lou QY, Jin X, He JY, Xiao WH,Zhai G#, Yin Z#. Androgen signaling inhibitsde novolipogenesis to alleviate lipid deposition in zebrafish.Zoological Research2024, 45(2):355-366.

10. Shi C, Zhang YQ, Lu Y, Lou QY, Shang GH, Peng XY, Dai XY, Jin X, He JY,Zhai G#, Yin Z#. Insights into the role of Fsh signaling in ovarian differentiation ofchorionic gonadotropin α(cgα)-deficient zebrafish.Zoological Research2025, 46(3): 695-708.

11.Zhai G1, Shu TT1, Xia YG, Jin X, He JY, Yin Z#. Androgen signaling regulates the transcription ofanti-Müllerian hormonevia synergy with SRY-Related Protein SOX9A.Science Bulletin2017, 62(3):197-203.

12. Shi SC, Zhang YQ, Huang JF, Lou QY, Jin X, He JY,Zhai G#, Yin Z#. Effective "off-on" switch for fertility control in female zebrafish.Frontiers in Marine Science2024, 11:1381305.

13. Yang BY1,Zhai G1, Gong YL1, Su JZ, Peng XY, Shang GH, Han D#, Jin JY, Liu HK, Du ZY, Yin Z., Xie SQ. Different physiological roles ofinsulin receptorsin mediating nutrient metabolism in zebrafish.American Journal of Physiology- Endocrinology and Metabolism2018, 315(1):E38-E51.

14. Yang BY1,Zhai G1, Gong YL, Su JZ, Han D#, Yin Z, Xie SQ. Depletion ofinsulin receptorsleads to β-cell hyperplasia in zebrafish.Science Bulletin2017, 62(7):486-492.

15.Zhai G, Gu QL, He JY, Lou QQ, Chen XW, Jin X, Bi EF#, Yin Z#.Sept6is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.Molecular and Cellular Biology2014, 34(7):1310-21.

16. Chen GH, Huang JF, Jia JY, Lou QY, Shi C, Yasheng MS, Zhao YJ, Yuan QY, Tang K, Liu XC, Wang ZK, Jiang DH, Qian XQ, Yin Z,Zhai G#. The food safety assessment of all-female common carp (Cyprinus carpio) (cyp17a1+/-;XX genotype) generated using genome editing technology.Food and chemical toxicology2023, 181:114103.

17.Zhai G1, Jia JY1, Bereketoglu C, Yin Z#, Prandhan A#. Sex-specific differences in zebrafish brains.Biology of sex differences2022, 13(1):31.

18. Ruan YL, Li XH,Zhai G#, Lou QY, Jin X, He JY, Yin Z#. Estrogen signaling inhibits the expression ofanti-aüllerian hormone(amh) andgonadal-soma-derived factor(gsdf) during the critical time of sexual fate determination in zebrafish.International Journal of Molecular Sciences2024, 25(3):1740.

19. Song J, Lu Y, Cheng XX, Shi C, Lou Q, Jin X, He JY,Zhai G#, Yin Z#. Functions of the thyroid-stimulating hormone on key developmental features revealed in a series of zebrafish dyshormonogenesis models.Cells2021, 10(8):1984.

20. Shi SC, Shu TT, Li X, Lou QY, Jin X, He JY, Yin Z andZhai G#. Characterization of the interrenal gland and sexual traits development incyp17a2-deficient zebrafish.Frontiers in Endocrinology2022, 13:910639.

21.Zhai G, Song J, Shu TT, Yan JJ, Jin X, He JY, Yin Z#. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish.Journal of Genetics and Genomics2017, 44(6):307-317.

22. Xi LW1,Zhai G1, Liu YL, Gong YL, Lu QS, Zhang ZM, Liu HK, Jin JY, Zhu XM, Yin Z#, Xie SQ, Han D#. Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish.Frontiers in Nutrition2023, 10:1187283.

23. Gong YL1,Zhai G1, Su JZ, Yang BY, Jin J, Liu HK, Yin Z#, Xie SQ, Han D#. Different roles ofinsulin receptor aandbin maintaining blood glucose homeostasis in zebrafish.General and Comparative Endocrinology2018, 269:33-45.

24. Shu TT, Shu YQ, Gao YP, Jin X, He JY,Zhai G#, Yin Z#. Depletion of tissue-specific ion transporters causes differential expression of PRL targets in response to increased levels of endogenous PRL.Frontiers in Endocrinology2018, 9:683.

25. Jia JY, Shi SC, Liu CY, Shu TT, Li TH, Lou QY, Jin X, He JY, Du ZY,Zhai G#, Yin Z. Use of all-malecyp17a1-deficient zebrafish (Danio rerio) for evaluation of environmental estrogens.Environmental Toxicology and Chemistry2024, 43(5):1062-1074.

二、代表性发明专利：

《实现XX/XY性别遗传决定型鱼类性别控制育种的方法及应用》、《规模化获得XX/XY性别决定的伪雄鱼亲本的育种方法及应用》、《鉴别黄河鲤遗传性别的分子标记、引物、试剂盒及应用》、《雌鱼育性控制的方法及应用》等多项专利已获授权，另有多项专利正在申报中。

欢迎有生物学背景的考生报考。