研究组长:李文祥（liwx@ihb.ac.cn）

    研究组成员：王桂堂（研究员）、吴山功（研究员）、李明（青年研究员）、邹红（高级实验师）、赵威山（项目副研究员）、研究生15名。

研究组介绍：主要从事水产动物疾病的基础和应用研究，研究领域涉及寄生虫学、微生物学和水产动物疾病控制。寄生虫学方面的研究内容包括寄生虫分类学、系统发育和协同进化、种群和群落生态学，以及寄生虫病的流行病学；微生物学方面的研究内容包括水体、底泥及水产动物肠道微生物群落的分子生态学、病原微生物学、微生物群落与疾病发生的关系以及微生态制剂的应用等；水产动物疾病控制主要包括寄生虫抗药性产生的分子机制、药物靶点发掘，以及水产动物疾病的药物防控和生态防控的应用基础研究。

近期研究兴趣：

·单殖吸虫的生态学，及基于鱼类行为的鱼病早期预警研究； 

·单殖吸虫抗药性产生的分子机制、药物靶点发掘，以及杀虫药物筛选； 

·寄生原虫与宿主的互作及致病机制，寄生原虫的适应性进化； 

·重要鱼类寄生纤毛虫病的疫苗研制，生态防控技术，精准靶标的发掘和药物研发； 

·入侵鱼类的外来寄生虫识别及入侵风险研究；

·益生菌修复肠道损伤的机制，基于肠道固有益生菌的鱼类重要疾病疫苗研制。

近期发表论文：

李文祥, 王浩, 习丙文, 李明, 聂品, 王桂堂. 寄生虫抗药性及其对水产动物寄生虫病药物防治的启示. 水生生物学报, 2024, 48(2): 1-10.

李明, 李文祥, 赵威山, 周伟钿, 步夏莲, 吴山功, 邹红, 王桂堂. 中国淡水鱼类寄生虫研究七十年. 水产学报, 2023, 47(11): 119414.

Shun Zhou, Xiao Jin, Ming Duan, Hong Zou, Ming Li, David J. Marcogliese, Guitang Wanga, Wenxiang Li. Potential effects of host competence and schooling behavior on parasite transmission in a host-pathogen system: a test of the dilution effect. International Journal for Parasitology, 2024, 54: 697–703.

Weishan Zhao, Jie Xiong, Ming Li, Xialian Bu, Chuanqi Jiang, Guangying Wang, Jing Zhang, Wenxiang Li, Hong Zou, Wei Miao, Kai Chen, Guitang Wang. Genome assembly of a symbiotic balantidia (Balantidium ctenopharyngodoni) in fish hindgut. Scientific Data, 2024, 11: 323.

Shangong Wu, Meijing Pan, Ziye Zan, Ivan Jakovlic, Weishan Zhao, Hong Zou, Einar Ringø, Guitang Wang. Regulation of lipid metabolism by gut microbiota in aquatic animals. Reviews in Aquaculture, 2024, 16: 34-46.

Weitian Zhou, Shiman Yang, Ke Huang, Weishan Zhao, Hong Zou, Wenxiang Li, Ming Li, Guitang Wang. Can Chilodonella uncinata induce cross-protection in koi carp (Cyprinus carpio) against Ichthyophthirius multifiliis? Evidence from immune response and challenge experiments. Aquaculture, 2024, 579: 740198.

Ivan Jakovlic, Hong Zou, Tong Ye, Hong Zhang, Xiang Liu, Chuanyu Xiang, Guitang Wang, Dong Zhang. Mitogenomic evolutionary rates in bilateria are influenced by parasitic lifestyle and locomotory capacity. Nature Communications, 2023, 14: 6307.

Xialian Bu, Weishan Zhao, Wenxiang Li, Hong Zou, Shangong Wu, Ming Li, Guitang Wang. Mitochondrial metabolism of the facultative parasite Chilodonella uncinata (Alveolata, Ciliophora). Parasites & Vectors, 2023, 16: 92.

Xialian Bu, Weishan Zhao, Zhongyang Li, Hongwei Ma, Yushun Chen, Wenxiang Li, Hong Zou, Ming Li, Guitang Wang. The energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi. BMC Genomics, 2023, 24: 624.

Guangran Hu, Ke Huang, Weitian Zhou, Runqiu Wang, Weishan Zhao, Hong Zou, Wenxiang Li, Shangong Wu, Ming Li, Guitang Wang. Comparison of droplet digital PCR and real-time quantitative PCR for quantitative detection of the parasitic ciliate Ichthyophthirius multifiliis in the water environment. Journal of Fish Diseases, 2023, 46(4): 357-367.

Ming Li, Giana Bastos Gomes, Weishan Zhao, Guangran Hu, Ke Huang, Tomoyoshi Yoshinaga, Theodore G. Clark, Wenxiang Li, Hong Zou, Shangong Wu, Guitang Wang. Cultivation of fish ciliate parasites: Progress and prospects. Reviews in Aquaculture, 2023, 15: 142-162.

Xiao Jin, Hong Zou, Ming Li, Shangong Wu, Guitang Wang, David J. Marcogliese and Wenxiang Li. Population growth of Gyrodactylus kobayashii in goldfish (Carassius auratus) associated with host density. Parasitology, 2022, 149: 1057-1064.

Xiao Jin, Wenxiang Li, Yingyin Cheng, Ming Li, Shangong Wu, Hong Zou, Guitang Wang. Description of Gyrodactylus banmae n. sp. (Monogenea, Gyrodactylidae) parasitic on zebrafish, Danio rerio. Parasitology International, 2022, 87: 102531.

Xiaoping Zhang, Baodi Shang, Yingyin Cheng, Guitang Wang, Stojmir Stojanovski,Wenxiang Li. Effects of different regimes of low temperature on egg hatching of Dactylogyrus vastator (Monogenea: Dactylogyridae). Experimental Parasitology, 2022, 240: 108333.

Peipei Fu, Fan Xiong, Shangong Wu, Hong Zou, Ming Li, Guitang Wang, Wenxiang Li. Effects of Schyzocotyle acheilognathi (Yamaguti, 1934) infection on the intestinal microbiota, growth and immune reactions of grass carp (Ctenopharyngodon idella). PLoS ONE, 2022, 17(4): e0266766.

Hong Zou, Hongpeng Lei, Rong Chen, Fanglin Chen, Wenxiang Li, Ming Li, Dong Zhang, Ivan Jakovli, Guitang Wang. Evolutionary rates of mitochondrial sequences and gene orders in Spirurina (Nematoda) are episodic but synchronized. Water Biology and Security, 2022, 1: 100033.

Wenxiang Li, Baojuan Yang, Jiangwen Cheng, Hong Zou, Ming Li, Guitang Wang. Seasonal dynamics of Dactylogyrus species (Monogenea: Dactylogyridae) on wild and farmed goldfish (Carassius auratus): Implication for prevention of dactylogyriasis. Aquaculture Reports, 2022, 26: 101327.

Weishan Zhao, Ming Li, Guangran Hu, Xialian Bu, Weitian Zhou, Wenxiang Li, Shangong Wu, Hong Zou, Guitang Wang. An infection mechanism of Balantidium ctenopharyngodoni, based on its prevalence and in vitro cultivation. Aquaculture, 2022, 458: 737686.

Guangran Hu, Weishan Zhao, Runqiu Wang, Hong Zou, WenxiangLi, Shangong Wu, Ming Li, GuitangWang. In vitro assessment of copper naphthenate against the free-living stages of Ichthyophthirius multifiliis. Aquaculture Reports, 2020: 17, 100404.

Dong Zhang, Fangluan Gao, I. Jakovlić, Hong Zou, Jin Zhang, Wenxiang Li, Guitang Wang. PhyloSuite: an integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies. Molecular Ecology Resources. 2019, 20: 348-355.

Dong Zhang, Wenxiang Li, Hong Zou, Shangong Wu, Ming Li, I. Jakovlić, Jin Zhang, Rong Chen, Guitang Wang. Homoplasy or plesiomorphy? Reconstruction of the evolutionary history of mitochondrial gene order rearrangements in the subphylum Neodermata. International Journal for Parasitology, 2019, 49: 819-829.

Fan Xiong, Shangong Wu, Lu Qin, Mijuan Shi, Wenxiang Li, Hong Zou, Ming Li, Guitang Wang. Transcriptome analysis of grass carp provides insights into disease-related genes and novel regulation pattern of bile acid feedback in response to lithocholic acid. Aquaculture, 2019, 500: 613-621.