研究组组长： 徐镇 研究员 

联系方式：Tel: 86-27-68780203

          E-mail: zhenxu@ihb.ac.cn

研究组成员：

徐镇（研究员）、孔维光（副研究员）、黄玉（高级工程师）、张倩倩（高级实验师）、张环宇（助理研究员）、李泽宇（博士后）、程高锋（博士后）、徐杨（博士后）、研究生15名、研究助理及客座学生10名。

研究组介绍：

本研究组致力于鱼类免疫防控与抗病育种的基础与应用研究，主要从两个方面开展工作：一是阐明病毒入侵和复制调控机制，揭示宿主抗病毒感染的黏膜免疫应答规律，开展鱼类黏膜疫苗及诊断技术研发与储备；二是解析鱼类抗病性状的分子调控机制，建立高效准确的鱼类基因组编辑育种技术，培育速生抗病优良品种。相关研究成果发表在Science Immunology、Science Bulletin、Cell Discovery、Nature Communications、PNAS、Microbiome、eLife等，获得国家自然科学基金、农业生物育种重大项目、中国科学院先导B专项等项目的支持。研究组突破GCRV-II敏感细胞系构建技术，创制首款草鱼GCRV-II灭活疫苗，免疫保护率达80%，转化金额8000万元。

主要研究方向：

1）鱼类病毒致病机制与免疫防控技术；

2）鱼类抗病分子遗传机制与育种技术；

代表性论文（#第一作者， *通讯作者）

1. Weiguang Kong^#, Peng Yang^#, Guangyi Ding^#, Baosheng Wu, Jianhua Zhao, Yong Shi, Chang Cai, Gaofeng Cheng, Zhen Xu^*. Gut-associated germinal center-like structures in teleosts reveal early origin of mucosal adaptive immunity. Science Bulletin, 2026, ISSN 2095-9273.

2. Peng Yang, Guangyi Ding, Gaofeng Cheng ,Xinyou Wang, Chang Cai, Qianqian Zhang, Ming Duan, Weiguang Kong, Zhen Xu^*. A non-neuronal mechanism of reovirus-induced behavioral abnormalities via targeting astrocytes in teleost fish. Science China Life Sciences, 2026, 2026-09-29.

3. Weiguang Kong, Peng Yang, Guangyi Ding, Chang Cai, Yong Shi, Gaofeng Cheng, Yang Ding, Zhen Xu^*. Ancestral germinal centers-like niches in teleost head kidney reveal early evolution of adaptive immunity. Fundamental Research, 2026, ISSN 2667-3258.

4. Weiguang Kong, Xinyou Wang, Guangyi Ding, Peng Yang, Yong Shi, Chang Cai, Xinyi Yang, Gaofeng Cheng, Fumio Takizawa, Zhen Xu^*. Newly discovered and conserved role of IgM against viral infection in an early vertebrate. eLife, 2025, 14:RP104465.

5. Gaofeng Cheng^#, Weiguang Kong^#, Ruiqi Lin, Zhihao Jiang, Xinyou Wang, Xueying Qin, Yong Shi, Peng Yang, Xiaoyun Chen, Lu Xia, Zhen Xu^*. Multi-omics analysis reveals that Bacillus spp. enhances mucosal antiviral immunity in teleost fish by mediating diglyceride production through lipid metabolism. Microbiome, 2025,13(1):123.

6. Weiguang Kong^#, Gaofeng Cheng^#, Jiafeng Cao^#, Jiaqian Yu, Xinyou Wang, Zhen Xu^*. Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity. Microbiome. 2024, 12, 10.

7. Yongyao Yu^#, Zhenyu Huang^#, Weiguang Kong^#, Fen Dong^#, Xiaoting Zhang, Xue Zhai, Gaofeng Cheng, Mengting Zhan, Jiafeng Cao, Liguo Ding, Guangkun Han, Fumio Takizawa, Yang Ding, J. Oriol Sunyer^*, Zhen Xu^*. Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses. Cell Discovery. 2022, 8:31.

8. Zhen Xu^#, Fumio Takizawa^#, Elisa Casadei, Yasuhiro Shibasaki, Yang Ding, Thomas J. C. Sauters, Yongyao Yu, Irene Salinas^*, J. Oriol Sunyer^*. Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. Science Immunology. 2020, 5(44): eaay3254.

9. Zhen Xu, Fumio Takizawa, David Parra, Daniela Gomez, Louise von Gersdorff Jorgensen, Scott E. LaPatra, J. Oriol Sunyer^*. Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Nature Communications. 2016, 7: 10728.

10. Zhen Xu^#, David Parra^#, Daniela Gomez^#, Irene Salinas, Yong-an Zhang, Louise von Gersdorff Jorgensen, Rasmus Demuth Heinecke, Kurt Buchmann, Scott LaPatra, J. Oriol Sunyer^*. Teleost skin, an ancient mucosal surface that elicits gut-like immune responses. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(32): 13097-13102.

代表专利

1. 徐镇；孔维光；朱宇超；张环宇；张秋实；丁广义。一株草鱼脑血管平滑肌细胞系及应用。中国，发明专利，ZL202610062377.2。

2. 徐镇；蔡畅；孔维光；霍宇。Tie1在作为草鱼呼肠孤II型病毒的受体中的应用。中国，发明专利，ZL 2026 1 0588483.4。

3. 徐镇；孔维光；袁新婕；程高锋。一种特异识别II型草鱼呼肠孤病毒VP4蛋白的兔源重组单克隆抗体、真核表达方法及应用。中国，发明专利，ZL 2025 1 0468867.8。

4. 徐镇；孔维光；袁新婕；程高锋。一种特异识别II型草鱼呼肠孤病毒VP56蛋白的重组兔单克隆抗体及其应用。中国，发明专利，ZL 2025 1 0780585.1。

5. 徐镇；程高锋；孔维光；王辛酉。一种适用于水产动物的免疫增强剂及其应用。中国，发明专利，ZL 2023 1 0530476.5。