鱼类低氧生物学研究组
研究组组长:肖武汉 研究员
研究组主要成员:刘兴 副研究员、王晶 副研究员、蔡孝廉 副研究员(项目)、朱纯纯 特别研究助理、李智 特别研究助理
主要研究兴趣:1. 鱼类耐低氧的遗传机制与耐低氧新种质创制。
2. 鱼类抗病毒感染的遗传机制与抗病新品种质创制。
3. 鱼类耐低氧与抗病毒交互影响的分子机制以及“双优”新种质创制。
代表性研究论文 (* 通讯作者)
(1)Xing Liu,Chunchun Zhu,Shuke Jia,Hongyan Deng,Jinhua Tang,Xueyi Sun,Xiaoli Zeng,Xiaoyun Chen,Zixuan Wang,Wen Liu,Qian Liao,Huangyuan Zha,Xiaolian Cai, Wuhan Xiao*. Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity. PNAS,2024,121 (17):e2314201121.
(2) Xing Liu,Jinhua Tang,Zixuan Wang,Chunchun Zhu,Hongyan Deng,Xueyi Sun,Guangqing Yu,Fangjing Rong,Xiaoyun Chen,Qian Liao,Shuke Jia,Wen Liu,Huangyuan Zha,Sijia Fan,Xiaolian Cai,Jian-Fang Gui,Wuhan Xiao*. Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3. Nature Communications,2024,15(1):3533.
(3) Xiaolian Cai,Rui Wang,Junji Zhu,Xiong Li,Xing Liu,Gang Ouyang,Jing Wang,Zhi Li,Chunchun Zhu,Hongyan Deng,Wuhan Xiao*. Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKɛ. Cell Reports,2024,43(1):113606.
(4) Junji Zhu,Xiong Li,Xiaolian Cai,Ziwen Zhou,Qian Liao,Xing Liu,Jing Wang,Wuhan Xiao*. Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity. PNAS,2023,120(36):e2214956120
(5) Xiaolian Cai,Ziwen Zhou,Junji Zhu,Xing Liu,Gang Ouyang,Jing Wang,Zhi Li,Xiong Li,Huanyuan Zha,Chunchun Zhu,Fangjing Rong,Jinghua Tang,Qian Liao,Wuhan Xiao*. Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cell Reports,2022,39(10):110920.
(6) Junji Zhu,Xiong Li,Xiaolian Cai,Huangyuan Zha,Ziwen Zhou,Xueyi Sun,Fangjing Rong,Jinghua Tang,Chunchun Zhu,Xing Liu,Sijia Fan,Jing Wang,Qian Liao,Gang Ouyang,Wuhan Xiao*. Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity. Molecular Cell,2021,81(15);3171-3186.
(7) Xing Liu,Chunchun Zhu,Huanyuan Zha,Jinhua Tang,Fanjing Rong,Xiaoyun Chen,Sijia Fan,Chenxi Xu,Juan Du,Junji Zhu,Jing Wang,Gang Ouyang,Guangqing Yu,Xiaolian Cai,Zhu Chen,Wuhan Xiao*. SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO Journal,2020,39 (11):e103285.
(8) Yu Chen,Chi Zhou,Wei Ji,Zhichao Mei,Bo Hu,Wei Zhang,Dawei Zhang,Jing Wang,Xing Liu,Gang Ouyang,Jiangang Zhou,Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumor growth. Nature Communications,2016,7: 11057.
(9) Jing Wang,Dawei Zhang,Juan Du,Chi Zhou,Zhi Li,Xing Liu,Gang Ouyang,Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research,2017,45(22):12700-12714.
(10) Xi Feng,Xing Liu,Wei Zhang,Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30(16):3397-3415.
其它研究论文(* 通讯作者)
2024
(1) Rui Wang,Xiaolian Cai,Xiong Li,Jun Li,Xing Liu,Jing Wang,Wuhan Xiao*. USP38 promotes deubiquitination of K11-linked polyubiquitination of HIF1α at Lys796 to enhance hypoxia signaling. Journal of Biological Chemistry,2024,300 (1):105532.
(2) Zhi Li,Jun Li,Ziyi Li,Yanan Song,Yanyi Wang,Chunling Wang,Le Yuan,Wuhan Xiao*,Jing Wang*,Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS Pathogens,2024,20(5):e1012227.
2023
(3) Hongyan Deng,Shuke Jia,Jinhua Tang,Fangjing Rong,Chenxi Xu,Xiaoyun Chen,Zixuan Wang,Chunchun Zhu,Xueyi Sun,Qian Liao,Wen Liu,Wenhua Li*,Wuhan Xiao*,Xing Liu*. SET7 methylates the deubiquitinase OTUB1 at Lys122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis. Journal of Biological Chemistry,2023,299 (4):103054.
(4) Qian Liao,Hongyan Deng,Zixuan Wang,Guangqing Yu,Chunchun Zhu,Shuke Jia,Wen Liu,Yao Bai,Xueyi Sun,Xiaoyun Chen,Wuhan Xiao*,Xing Liu*,Deletion of prolyl hydroxylase 3 (phd3) in zebrafish facilitates hypoxia tolerance. Journal of Biological Chemistry,2023,299 (12):105420.
(5) Yanan Song,Sijia Fan,Dawei Zhang,Jun Li,Zhi Li,Ziyi Li,Wuhan Xiao*,Jing Wang*. Zebrafish maoc1 attenuates spring viremia of carp virus propagation by promoting autophagy-lysosome-dependent degradation of viral phosphoprotein. Journal of Virology,2023,97 (2):e0133822.
(6) Qian Liao,Chunchun Zhu,Xueyi Sun,Zixuan Wang,Xiaoyun Chen,Hongyan Deng,Jinhua Tang,Shuke Jia,Wen Liu,Wuhan Xiao*,Xing Liu*. Disruption of sirtuin 7 in zebrafish facilities hypoxia tolerance. Journal of Biological Chemistry,2023,299 (8):105074.
(7) Gang Ouyang,Qian Liao,Sijia Fan,Xiaolian Cai,Jing Wang,Xing Liu,Wuhan Xiao*. Zebrafish mavs is essential for antiviral innate immunity. Journal of Immunology,2023,210 (9):1314-1323.
(8) Xing Liu,Fangjing Rong,Jinhua Tang,Chunchun Zhu,Xiaoyun Chen,Shuke Jia,Zixuan Wang,Xueyi Sun,Hongyan Deng,Huangyuan Zha,Gang Ouyang,Wuhan Xiao*. Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage. Cell Death and Differentiation,2022,29(4):722-736.
(9) Jinhua Tang,Hongyan Deng,Zixuan Wang,Huanyuan Zha,Qian Liao,Chunchun Zhu,Xiaoyun Chen,Xueyi Sun,Shuke Jia,Gang Ouyang,Xing Liu*,Wuhan Xiao*. EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1αis repressed by SET7-catalyzed lysine methylation. Journal of Biological Chemistry,2022,298(6):101961.
(10) Xiaoyun Chen,Sijia Fan,Chunchun Zhu,Qian Liao,Jinhua Tang,Guangqing Yu,Xiaolian Cai,Gang Ouyang,Wuhan Xiao*,Xing Liu*. Zebrafish sirt5 negatively regulates antiviral innate immunity by attenuating phosphorylation and ubiquitination of mavs. Journal of Immunology,2022,209(6):1165-1172.
(11) Xing Liu,Hongyan Deng,Jinhua Tang,Zixuan Wang,Chunchun Zhu,Xiaolian Cai,Fangjing Rong,Xiaoyun Chen,Xueyi Sun,Shuke Jia,Gang Ouyang,Wenhua Li*,Wuhan Xiao*. OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1αduring hypoxia adaptation. Cell Death and Disease. 2022,13(6):560.
(12) Zixuan Wang,Xiaoyun Chen,Sijia Fan,Chunchun Zhu,Hongyan Deng,Jinhua Tang,Xueyi Sun,Shuke Jia,Qian Liao,Wuhan Xiao*,Xing Liu*. Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activity. Journal of Biological Chemistry,2022,292(12):102633.
2021
(13) Junji Zhu,Xiong Li,Xueyi Sun,Ziwen Zhou,Xiaolian Cai,Xing Liu,Jing Wang,Wuhan Xiao*. Zebrafish prmt2 attenuates antiviral innate immunity by targeting traf6. Journal of Immunology,2021,207(10):2570-2580.
(14) Ziwen Zhou,Xiaolian Cai,Junji Zhu,Zhi Li,Guangqing Yu,Xing Liu,Gang Ouyang,Wuhan Xiao*. Zebrafish otud6b negatively regulates antiviral responses by suppressing K63-linked ubiquitination of irf3 and irf7. Journal of Immunology,2021,207(1):244-256.
(15) Qian Liao,Gang Ouyang,Junji Zhu,Xiaolian Cai,Guangqing Yu,Ziwen Zhou,Xing Liu,Wang Jing,Wuhan Xiao*. Zebrafish sirt7 negatively regulates antiviral responses by attenuating phosphorylation of irf3 and irf7 independently of its enzymatic activity. Journal of Immunology,2021,207(12):3050-3059.
(16) Junji Zhu,Wuhan Xiao*. A proteomics protocol to identify stimulation-induced binding partners dependent on a specific gene in mammalian cells. STAR Protocols,2021,2(4):100962.
2020
(17) Sijia Fan , Jing Wang, Guangqing Yu , Fangjing Rong, Dawei Zhang, Chenxi Xu , Juan Du, Zhi Li , Gang Ouyang , Wuhan Xiao* . TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation. Journal of Biological Chemistry, 2020,295(48):16299-16313.
(18) Xiaolian Cai,Ziwen Zhou,Junji Zhu,Qian Liao,Dawei Zhang,Xing Liu,Jing Wang,Gang Ouyang,Wuhan Xiao*. Zebrafish hif-3a modulates erythropoiesis via regulation of gata-1 to facilitate hypoxia tolerance. Development,2020,147 (22):dev.185116.
(19) Guangqing Yu,Xing Liu,Dawei Zhang,Jing Wang,Gang Ouyang,Zhu Chen,Wuhan Xiao*. Zebrafish nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development,2020,147(18):dev.194886.
(20) Zhi Li,Sijia Fan,Jing Wang,Xiaoyun Chen,Qian Liao,Xing Liu,Gang Ouyang,Hong Cao,Wuhan Xiao*. Zebrafish F-box protein fbxo3 negatively regulates antiviral response through promoting K27-linked polyubiquitination of the transcription factors irf3 and irf7. Journal of Immunology,2020,205(7):1897-1908.
(21) Guangqing Yu,Xiong Li,Ziwen Zhou,Jinhua Tang,Jing Wang,Xing Liu,Sijia Fan,Gang Ouyang,Wuhan Xiao*. Zebrafish phd3 negatively regulates antiviral responses via suppression of Irf7 transactivity independent of its prolyl hydroxylase activity.Journal of Immunology,2020,205(4):1135-1146.
(22) Gang Ouyang,Qian Liao,Dawei Zhang,Fangjing Rong,Xiaolian Cai,Sijia Fan,Junji Zhu,Jing Wang,Xing Liu,Xueqin Liu,Wuhan Xiao* . Zebrafish NF-kB/p65 is required for antiviral responses. Journal of Immunology, 2020,204(11):3019-3029.
(23) Junji Zhu,Xing Liu,Xiaolian Cai,Gang Ouyang,Sijia Fan,Jing Wang,Wuhan Xiao*. Zebrafish prmt7 negatively regulates antiviral response by suppressing the retinoic acid-inducible gene 1-like receptor signaling.FASEB Journal,2020,34(1):988-1000.
(24) Junji Zhu,Xing Liu,Xiaolian Cai,Gang Ouyang,Huangyuan Zha,Ziwen Zhou,Qian Liao,Jing Wang,Wuhan Xiao*. Zebrafish prmt3 negatively regulates antiviral responses. FASEB Journal, 2020,34(8):10212-10227.
2019
(25) Junji Zhu,Dawei Zhang,Xing Liu,Guangqing Yu,Xiaolian Cai,Chenxi Xu,Fangjing Rong,Gang Ouyang,Jing Wang,Wuhan Xiao*. Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. Development,2019,146(20):dev179572.
(26) Guangqing Yu,Xing Liu,Jinghua Tang,Chenxi Xu,Gang Ouyang,Wuhan Xiao*. Neddylation facilitates the antiviral response in zebrafish. Frontiers in Immunology,2019,10: 1432.
2018
(27) Xiaolian Cai,Dawei Zhang,Jing Wang,Xing Liu,Gang Ouyang,Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry,2018,293(40):15370-15380.
(28) Chenxi Xu,Xing Liu,Huangyuan Zha,Sijia Fan,Dawei Zhang,Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens,2018,18(8):e1007259.
2017
(29) Dawei Zhang,Jing Wang,Chi Zhou,Wuhan Xiao*. Zebrafish akt2 is essential for survival,growth,bone development,and glucose homeostasis. Mechanisms of Development, 2017,143:42-52.
2016
(30) Xing Liu,Xiaolian Cai,Dawei Zhang,Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016,197(12):4736-4749.
(31) Xing Liu,Xiaolian Cai,Bo Hu,Zhichao Mei,Dawei Zhang,Gang Ouyang,Jing Wang,Wei Zhang,Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry,2016,291(49):25692-25705.
2015
(32) Xing Liu,Zhu Chen,Chenxi Xu,Xiaoqian Leng,Hong Cao,Gang Ouyang,Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015,43(10):5081-5098.
(33) Xing Liu,Zhu Chen,Gang Ouyang,Tieshan Song,Huageng Liang,Wei Liu, Wuhan Xiao*. ELL associated f actor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry,2015,290(43):25933-25945.
(34) Juan Du,Dawei Zhang. Wei Zhang,Gang Ouyang,Jing Wang,Xing Liu,Sun Li,Wei Liu,Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology,2015,195(4):1782-1790.
(35) Zhichao Mei,Dawei Zhang,Bo Hu,Jing Wang,Xian Shen,Wuhan Xiao*. FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity. Journal of Biological Chemistry,2015,290(26):16202-16214.
2014
(36) Bo Hu,Wei Zhang,Xi Feng,Wei Ji,Xunwei Xie,Wuhan Xiao*. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis,Developmental Biology,2014,388: 81-93.
(37) Jing Wang,Wei Zhang,Wei Ji,Xing Liu,Gang Ouyang,Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology,2014,28(2):239-248.
(38) Zhu Chen,Xing Liu,Zhichao Mei,Zhou Wang*,Wuhan Xiao*. EAF2 suppresses HIF-1a transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology,2014,34(6):1085-1099.
(39) Wei Zhang,Wei Ji,Xing Liu,Gang Ouyang,Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology,2014,34(4):765-775.
(40) Wei Ji,Jing Wang,Wei Zhang,Xing Liu,Gang Ouyang,Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014,457: 185-195.
2013
(41) Jing-xia Liu,Dawei Zhang,Xunwei Xie,Gang Ouyang,Xing Liu,Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development,2013,140: 1067-1078.
2011
(42) Xiaoyang Wan,Bo Hu,Jing-xia Liu,Xi Feng,Wuhan Xiao*. Zebrafish mll gene is essential for hematopoiesis. Journal of Biological Chemistry, 2011,286: 33345-33357.
2009
(43) Jiangang Zhou,Xi Feng,Bing Ban,Jing-xia Liu,Zhou Wang*,Wuhan Xiao*. The elongation factor ELL (Eleven-nineteen lysine-rich leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. Journal of Biological Chemistry,2009,284(28):19142-19152.
(44) Jing-xia Liu,Bo Hu,Yang Wang,Jianfang Gui,Wuhan Xiao*. Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. Journal of Biological Chemistry,2009,284(24):16679-16692.