研究组成员：

柯飞（副研究员）、张奇亚（研究员）、梁博（特别研究助理）、研究生及客座学生8名。

研究组介绍：

水生病毒学研究组高度关注引起疫病流行的水产动物病毒及以纳米尺度驱动地球生物地理化学循环的水生微生物病毒，长期并将继续致力于水生病毒及其分子生物学研究。

该研究组成立20多年来，在张奇亚研究员的带领和团队成员的共同努力下，围绕水生病毒病原分离鉴定，病毒基因组的结构特征及关键基因功能、病毒复制、遗传进化、病毒与宿主及水环境相互作用、水产病毒病检测与防控技术等进行了长期和深入研究。在构建水生病毒学研究技术体系的基础上，从患病两栖类、鱼类和甲壳类等水产动物中、和从有害藻类中鉴定出各种病毒病原；解析六个科10多种水生病毒全基因组；阐明一批水生病毒关键基因结构特征与生物功能；揭示蛙病毒致病和跨种感染复制的分子机制。获湖北省自然科学奖2项。

未来，研究组将继续坚持水生病毒及其分子生物学研究，关注新发及再发水生病毒入侵感染及基因组复制转录机制；探讨水生病毒怎样感染不同宿主，以期阐释水生病毒感染及跨种传播的机制，从中寻找抵抗病毒疫病或利用、改造病毒生物资源的方法。

主要研究兴趣：

1. 新发及再发水生病毒病原的分离鉴定；

2. 水生病毒复制周期、遗传和进化、病毒与宿主及水环境的互作机制；

3. 研发水产病毒病检测与防控技术；水生病毒资源的发掘与应用。

近期研究的主要领域：

1.重要水产动物（鲫、草鱼、鳜等）病毒病原的基因组复制转录、致病与传播及病原与宿主互作分子机制；

2. 噬藻体侵染及与宿主藻互作机制；

3. 水生病毒学研究新技术。

代表性论文与著作：

代表论著题录：

张奇亚,桂建芳著. 2012. 水生病毒及病毒病图鉴. 科学出版社,北京pp1-479.

张奇亚,桂建芳. 2008. 水生病毒学(研究生教材). 高等教育出版社,北京pp1-414.

参编英文论著:

Gray MJ, Chinchar VG (eds). 2015.Ranaviruses Lethal Pathogens of Ectothermic Vertebrates. Springer. Pp 105-139

Gui JF,Tang QS,Li ZJ,Liu JS,Silva SSDe (eds). 2018. Chinese Aqaculture: Succes Stories and Modern Trends. Chichester,UK: Wiley UK. Pp 577-598

获奖成果

“水产动物不同病毒基因组解析及病毒与宿主相互作用的分子机制” 获湖北省自然科学二等奖 (2017)

“重要水产动物病毒病原的鉴定及致病机理研究” 获湖北省自然科学二等奖 (2004)

近年部分论文题录:

Meng LH,Ke F,Zhang QY,Hu YD,Zhao Z. A GH19 lysozyme and peptidase from Myoviridae cyanophages lacking the typical holin-endolysin system exhibit lytic activity. Enzyme and Microbial Technology 2024,173: 110368.

Jiang QQ,Li Z,Zhang QY,Ke F. A novel cell line established from skin tissue of gibel carp (Carassius gibelio) is susceptible toCarassius auratusherpesvirus infection. Water Biology and Security 2024,3: 100253.

Meng XY,Jiang QQ,Yu XD,Zhang QY,Ke F. Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Siniperca chuatsi rhabdovirus (SCRV) infection through two distinct mechanisms. J Virol. 2023,97: e0122623.

Ke F,Zhang QY. Advances on genomes studies of large DNA viruses in aquaculture: A minireview. Genomics. 2023,115:110720.

Jiang QQ,Meng XY,Yu XD,Zhang QY,Ke F. Fusing a TurboID tag with the Andrias davidianus ranavirus 2L reduced virus adsorption efficiency. Microb Pathog. 2023,182: 106220.

Yu XD,Ke F,Zhang QY,Gui JF. Genome characteristics of two ranavirus isolates from mandarin fish and largemouth bass. Pathogens. 2023,12: 730.

Meng LH,Ke F,Zhang QY,Zhao Z. Biological and genomic characteristics of MaMV-DH01,a novel freshwater Myoviridae cyanophage strain. Microbiol Spectr. 2023,11: e0288822.

Ke F,Yu XD,Wang ZH,Gui JF,Zhang QY. Replication and transcription machinery for ranaviruses: components,correlation,and functional architecture. Cell Biosci. 2022,12: 6.

Ke F,Zhang QY. ADRV 12L: A ranaviral putative Rad2 family protein involved in DNA recombination and repair. Viruses. 2022,14: 908.

Ke F,Wang RB,Wang ZH,Zhang QY. Andrias davidianus ranavirus (ADRV) genome replicate efficiently by engaging cellular mismatch repair protein MSH2. Viruses. 2022,14: 952.

Ke F,Meng XY,Zhang QY. Siniperca chuatsi rhabdovirus (SCRV)-induced key pathways and major antiviral genes in fish cells. Microorganisms 2022,10: 2464.

Meng XY,Wang ZH,Yu XD,Zhang QY,Ke F. Development and characterization of a skin cell line from Chinese perch (Siniperca chuatsi) and its application in aquatic animal viruses. J Fish Dis. 2022,45:1439-1449.

Wang ZH,Ke F,Gui JF,Zhang QY. Environmental factors and their threshold affecting the survival of five aquatic animal viruses in different animal cells. Viruses. 2022,14:2546.

Zhang QY,Ke F,Gui L,Zhao Z,Recent insights into aquatic viruses: Emerging and reemerging pathogens,molecular features,biological effects,and novel investigative approaches. Water Biology and Security 2022,1: 100062.

Wang ZH,Ke F,Zhang QY,Gui JF. Structural and functional diversity among five RING finger proteins from Carassius auratus herpesvirus (CaHV). Viruses. 2021,13: 254.

Ke F^#,Gui L^#,Li T,Li FH,Zhao X,Chen ZY,Lei CK,Zhang QY. The features of an emerging whispovirus isolate from freshwater crayfish. Aquaculture Reports. 2021,20: 100728.

Zhao YH,Zeng XT,Zhang QY. Fish herpesvirus protein (CaHV-138L) can target to mitochondrial protein FoF1 ATPase. Virus Res. 2020,275:197754.

Yu NT,Ke F,Zhang QY. Andrias davidianus ranavirus 1R encoding a delayed-early protein promotes cell proliferation by driving cell cycle progression into S phase. Acta Virol. 2020,64:10-19.

Ke F,Wang ZH,Ming CY,Zhang QY. Ranaviruses bind cells from different species through interaction with Heparan Sulfate. Viruses. 2019,11. pii: E593.

Ke F,Zhang QY. Aquatic animal viruses mediated immune evasion in their host. Fish Shellfish Immunol. 2019,86:1096-1105.

Li T,Ke F,Gui JF,Zhou L,Zhang XJ,Zhang QY. Protective effect of Clostridium butyricum against Carassius auratus herpesvirus in gibel carp. Aquaculture International. 2019,27(3):905-914.

Ke F,Gui JF,Chen ZY,Li T,Lei CK,Wang ZH,Zhang QY.  Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander. BMC Genomics. 2018,19: 211.

Chen ZY,Li T,Gao XC,Wang CF,Zhang QY. Protective Immunity Induced by DNA Vaccination against Ranavirus Infection in Chinese Giant Salamander Andrias davidianus. Viruses. 2018,10. pii: E52.

Cao YS,Wang D,Li SW,Xu LM,Zhao JZ,Liu HB,Lu TY,Zhang QY. Identification and analysis of differentially expressed microRNAs in rainbow trout (Oncorhynchus mykiss) responding to infectious hematopoietic necrosis virus infection. Developmental and Comparative Immunology. 2018,88: 28-36.

Gui L,Chinchar VG,Zhang QY. Molecular basis of pathogenesis of emerging viruses infecting aquatic animals. Aquaculture and Fisheries. 2018,3: 1-5.

Gui L,Li T,Zhang QY. Fish kidney cells show higher tolerance to hyperosmolality than amphibian. Aquaculture and Fisheries. 2018,3: 135-138.

Chinchar VG,Hick P,Ince IA,Jancovich JK,Marschang R,Qin Q,Subramaniam K,Waltzek TB,Whittington R,Williams T,Zhang QY,Ictv Report Consortium. 2017. ICTV Virus Taxonomy Profile: Iridoviridae. Journal of General Virology. 98: 890-891.

Zhang QY,Gui JF. 2015. Virus genomes and virus-host interactions in aquaculture animals. Sci China Life Sci. 58: 156-169.