学科组长：张义兵 研究员/博士生导师    

　　学科组成员：丹成博士，在读研究生4人 

　　学科组介绍：本实验室主要聚焦鱼类响应病毒感染的天然免疫分子机理及应用。致力于挖掘鱼类响应病毒感染的相关基因，解析相关基因的功能、调控机制及信号通路，发现特异于鱼类物种的抗病毒感染免疫规律，尤其是鱼类干扰素介导的天然抗病毒免疫反应的分子机理，鉴定潜在应用于鱼类抗病育种实践的关键分子。目前的主要研究方向有：抗病毒感染的分子机制及分子调控；抗病毒因子的功能及应用；脊椎动物免疫系统发育及分子进化。近5年来在Journal of Immunology等刊物发表论文十多篇。   

　　联系方式：电话：027-68780663；Email: ybzhang@ihb.ac.cn 

　　近年发表论文： 

　　1. Zhao X, Gong XY, Li YL, Dan C, Gui JF, Zhang YB^*. Characterization of DNA binding and nuclear retention identifies zebrafish-specific IRF11 as a positive regulator of IFN antiviral response. Journal of Immunology. 2020, 205 (1):237-250 

　　2. Wu CX, Zhang YB^* and Hu CY^*. PKZ, a Fish-Unique eIF2 Kinase Involved in Innate Immune Response. Front. Immunol. 2020,11:585. 

　　3. Xiong Y, Dan C, Ren F, Su Z, Zhang YB^*, Mei J^*. Proteomic profiling of yellow catfish (Pelteobagrus fulvidraco) skin mucus identifies differentially-expressed proteins in response to Edwardsiella ictaluri infection. Fish Shellfish Immunol. 2020;100:98-108. 

　　4. Zang ZX, Dan C, Zhou L, Zhang QY, Gui JF, Zhang YB^*. Function characterization and expression regulation of two different-sized 3’untranslated region-containing interferon genes from clone F of gibel carp Carassius auratus gibelio. Molecular Immunology, 2020,119:18–26. 

　　5. Song W, Zhang YB, Zhang XJ, Gui, JF. De Novo Transcriptome Assembly of Four Organs of Collichthys Lucidus and Identification of Genes Involved in Sex Determination and Reproduction. PLoS One. 2020 Mar 27;15(3):e0230580.  

　　6. Wu M, Dan C, Gui JF, Zhang YB^*. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription. Fish & Shellfish Immunology, 2019;90:180-187. 

　　7. Wu M, Zhao X, Gong XY, Wang Y, Gui JF, Zhang YB^*. FTRCA1, a species-specific member of finTRIM family, negatively regulates fish interferon response through autophage-lysosomal degradation of TBK1. Journal of Immunology, 2019,  202  (8):  2407-2420 

　　8. Gong XY, Zhang QM, Gui JF, Zhang YB^*. SVCV infection triggers fish IFN response through RLR signaling pathway. Fish & Shellfish Immunology, 2019, 86:1058-1063 

　　9. Zhang QM, Zhao X, Li Z, Wu M, Gui JF, Zhang YB^*. Alternative splicing transcripts of zebrafish LGP2 gene differentially contributes to interferon antiviral response. Journal of Immunology, 2018,  200  (2):  688-703 

　　10. Gao FX, Lu WJ, Wang Y, Zhang QY, Zhang YB, Mou CY, Li Z, Zhang XJ, Liu CW, Zhou L, Gui JF. Differential expression and functional diversification of diverse immunoglobulin domain-containing protein (DICP) family in three gynogenetic clones of gibel carp. Dev Comp Immunol. 2018;84:396-407.  

　　11. Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep. 2017;21(1):195-207. 

　　12. 熊亚玮，张义兵^*，桂建芳。斑马鱼IRF11基因的鉴定、亚细胞定位及表达特征。水生生物学报，2017 , 41 (1) :1-8。 

　　13. Feng H, Zhang QM, Zhang YB^*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3, and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes. Journal of Immunology, 2016, 197(5):1893-904. 

　　14. Chen C, Zhang YB^*, Gui JF. Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes. Dev Comp Immunol, 2015, 52:112–122。 

　　15. Feng H, Zhang YB^*, Zhang QM, Li Z, Zhang QY, Gui JF^*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNj1 and IFNj3 promoters downstream of MyD88 signaling. Journal of Immunology, 2015, 194: 1225–1238.