环境生物化学与微生物学
该学科组的主要研究领域包括环境科学、微生物生态学、分子微生物学、环境微生物学、藻类生态学、环境工程学和恢复生态学等，主旨是着力从生物化学和微生物的角度深入研究水环境问题，以期描述污染水体的生态格局，揭示胁迫的本质，并以此为基础为水环境改善提供技术支撑。近期研究焦点包括：
1） 富营养化的发生机理与控制技术研发，包括功能微生物介导的碳、氮、硫和磷等营养元素的循环与迁移转化、藻类对营养的利用策略与水华暴发与演替机理以及基于上述研究结果研发的沉积物污染控制技术、湖滨带污染拦截与生态修复技术、蓝藻水华防控技术等。
2） 环境微生物与分子技术研发，包括细菌分子遗传学与合成生物学、活性污泥微生物组学与生物多样性、微生物氮代谢与氮循环、水生动物肠道微生物和生物絮团技术、化工废水和垃圾渗滤液处理、黑臭水体治理与生态修复、蓝藻水华控制和蓝藻生物质利用等。
3） 低污染水处理技术研发，包括人工湿地处理技术、土地处理技术、生物过滤系统技术研发以及相关产品和装置研制等。
近年来先后承担了国家“十一五”、“十二五”、“十三五”重大科技专项、国家重点研发计划-战略性国际科技创新合作重点专项、国家自然科学基金重点和面上项目、中国科学院知识创新工程重要方向项目、交叉项目以及政府间科技合作项目（包括中国-乌克兰、中国-俄罗斯、中国-波兰、中国-意大利、中国-保加利亚、中国-丹麦、中国-捷克、中国-匈牙利、中国-斯洛文尼亚、中国-韩国等），已在“Environmental Microbiology”、“Water Research”、 “Environmental Science & Technology” 、 “Applied and Environmental Microbiology” 、“Bioresource Technology”、“Science of the Total Environment”等期刊上发表SCI收录论文100余篇。
学科组长：曹秀云研究员/博士（caoxy@ihb.ac.cn；+86 27 68780221）
主要成员：
周易勇研究员/博士 (zhouyy@ihb.ac.cn；+86 27 68780709）
邱东茹研究员/博士 (qiu@ihb.ac.cn; +86 27 68780215)
宋春雷副研究员/博士 (clsong@ihb.ac.cn；+86 27 68780221）
博士后：万玲玲博士(wanlingling@ihb.ac.cn)
李筱炆博士(lixw@ihb.ac.cn)
袁思亮博士 (yuansl@ihb.ac.cn； +86 27 68780609)
近五年主持项目情况:
1、 国家重点研发计划“合成生物学”专项：“活性污泥人工多细胞体系构建与应用”项目子课题，2020-2024，204万元；
2、 国家自然科学基金与欧盟委员会环境生物技术合作项目：“合成塑料降解转化微生物菌群”课题3“合成塑料解聚酶的人工设计与定向进化”任务3“合成塑料解聚酶的克隆”，2020-2023，55万元；
3、 国家自然科学基金重大研究计划培育项目：“细菌反硝化脱氮与异化型硝酸盐还原氨化的分子决定机制研究”，2018-2020，101万元；
4、 国家自然科学基金面上项目：固氮与非固氮蓝藻营养利用优势的交互作用驱动其水华演替的机制研究，2022-2025，57万元；
5、 国家自然科学基金青年基金项目：微囊藻水华过程中磷营养竞争优势的耦合机制与启动条件研究，2022-2024，30万元；
6、 国家自然科学基金青年基金项目：硫循环在硝酸盐异化还原为铵和厌氧氨氧化过程及其耦联中的作用，2022-2024，30万元；
7、 国家自然科学基金面上项目：微囊藻与长孢藻附着细菌驱动的氮转化途径与机制及其对藻类生长的影响，2021-2024，57万元；
8、 国家重点研发计划（蓝色粮仓）子课题：基于微生物环调控的饵料生物生产力优化技术，2020-2023，65万元；
9、 中科院美丽中国项目：陆向岸线景观斑块最小保护面积与优化空间配置，2019-2023，90万元；
10、国家自然科学基金面上项目：湖泊沉积物硝酸盐异化还原为铵与反硝化过程的偶联作用及其对藻类演替的影响，2019-2022，61万元。
11、国家重点研发计划：“一带一路”沿线国家海洋赤潮与低氧等生态灾害的发生机制与早期预警和应急保障系统的关键技术研究，2017-2022，1469万元；
12、“十三五”水专项子课题：清水廊道（水质保障）技术验证评估与示范应用，2018-2022，210万元；
13、国家重点研发计划（蓝色粮仓）子课题：池塘养殖系统内生源要素归趋及对受纳湖泊氮磷循环的影响机制，2019-2022，80万元；
14、国家基金重大研究计划培育项目：蓝藻以非磷脂类替代磷脂响应磷胁迫的生物化学机制研究，2020-2022，79万元；
15、国家自然科学基金面上项目：巢湖藻类碎屑有机碳调节水华种类演替的机制研究，2015-2019，85万元。
16、中国科学院国际人才项目计划2020国际访问学者项目；
17、政府间国际合作项目若干 ；
18、地方企业项目若干 。
近5年发表文章：
2022年
[1] Gao, N., Dai, J.C., Liu, Y.Q., Li, S.Y., Wang, J., Lu, W.X. and Qiu, D.R.* 2022. Cellulose-mediated floc formation by the activated sludge bacterium Shinella zoogloeoides ATCC 19623. BMC Microbiol 22(1).
[2] Liu, X.H., Chen, J., Liu, Y., Wan, Z.F., Guo X.C.*, Lu S.Y., Qiu D.R.*. 2022. Sulfamethoxazole degradation by Pseudomonas silesiensis F6a isolated from bioelectrochemical technology-integrated constructed wetlands. Ecotox Environ Safe 240: 113698.
[3] Liu, Y.Q., Li, S.Y., Lin, J., Liu, S.Y., Wei, H.H., Dai, J.C., Qiu, D.R.*. Pseudaquidulcibacter sacchrophilus gen. nov., sp. nov., a novel member of family Caulobacteraceae, isolated from the outlet of a water purification equipment with starch as a carbon source. Int J Syst Evol Microbiol 72(2).
[4] Gao, J.K.1, Liu, G.L.1, Li, X.W., Tang, M.J., Cao, X.Y., Zhou, Y.Y. and Song, C.L.* 2022. Organic carbon quantity and composition jointly modulate the differentiation of nitrate reduction pathways in sediments of the Chinese eutrophic lake, Lake Chaohu. Water Res 220.
[5] Lin, L.L., Li, Z.W., Zhang, B., Zhang, Q.Q., Qiu, D.R., Herzberg, M., Wu, Z.B. and Xiao, E.R.* 2022. Degradation and utilization of EPS from excessive activated sludge by interaction of electrogenesis and light stimulation. J Environ Chem Eng 10(3).
[6] Song, X.Y., Zhang, Z.H., Dai, Y.R., Cun, D.S., Cui, B.H., Wang, Y.W., Fan, Y.C., Tang, H.B., Qiu, L., Wang, F.H., Qiu, D.R.* and Liang, W.* 2022. Biodegradation of phthalate acid esters by a versatile PAE-degrading strain Rhodococcus sp. LW-XY12 and associated genomic analysis. Int Biodeter Biodegr 170.
[7] Yu, H., Yan, X.Z., Weng, W.L., Xu, S.H., Xu, G.Z., Gu, T.Y., Guan, X.T., Liu, S.W., Chen, P.B., Wu, Y.J., Xiao, F.S., Wang, C., Shu, L.F., Wu, B., Qiu, D.R., He, Z.L. and Yan, Q.Y.* 2022. Extracellular proteins of Desulfovibrio vulgaris as adsorbents and redox shuttles promote biomineralization of antimony. J Hazard Mater 426.
2021年
[8] Liu, S.Y., Dai, J.C., Wei, H.H., Li, S.Y., Wang, P., Zhu, T.B., Zhou, J.Z. and Qiu, D.R.* 2021. Dissimilatory nitrate reduction to ammonium (DNRA) and denitrification pathways are leveraged by cyclic amp receptor protein (CRP) paralogues based on electron donor/acceptor limitation in Shewanella loihica PV-4. Appl Environ Microb 87(2).
[9] Chai, X.J., Li, X.W., Hii, K.S., Zhang, Q., Deng, Q.H., Wan, L.L., Zheng, L.L., Lim, P.T., Tan, S.N., Mohd-Din, M., Song, C.L., Song, L.R., Zhou, Y.Y. and Cao, X.Y.* 2021. Blooms of diatom and dinoflagellate associated with nutrient imbalance driven by cycling of nitrogen and phosphorus in anaerobic sediments in Johor Strait (Malaysia). Mar Environ Res 169.
[10] Hossain, M.S., Dai, J.C. and Qiu, D.R.* 2021. Dysbiosis of the shrimp (Penaeus monodon) gut microbiome with AHPND outbreaks revealed by 16S rRNA metagenomics analysis. Aquac Res 52(7), 3336-3349.
[11] Hossain, M.S., Dai, J.C. and Qiu, D.R.* 2021. European eel (Anguilla anguilla) GI tract conserves a unique metagenomics profile in the recirculation aquaculture system (RAS). Aquacult Int 29(4), 1529-1544.
[12] Kim, D.D.1, Wan, L.L.1, Cao, X.Y., Klisarova, D., Gerdzhikov, D., Zhou, Y.Y., Song, C.L.* and Yoon, S.* 2021. Metagenomic insights into co-proliferation of Vibrio spp. and dinoflagellates Prorocentrum during a spring algal bloom in the coastal East China Sea. Water Res 204.
[13] Li, H., Song, C.L.*, Yang, L., Qin, H.D., Cao, X.Y. and Zhou, Y.Y. 2021. Phosphorus supply pathways and mechanisms in shallow lakes with different regime. Water Res 193.
[14] Li, H., Song, C.L. *, Yang, L., Qin, H.D., Cao, X.Y. and Zhou, Y.Y. 2021. Nutrients regeneration pathway, release potential, transformation pattern and algal utilization strategies jointly drove cyanobacterial growth and their succession. J Environ Sci 103, 255-267.
[15] Mubashar, M., Ahmad, Z.L., Li, C., Zhang, H.Y., Xu, C., Wang, G.H., Qiu, D.R., Song, L.R. and Zhang, X.Z.* 2021. Carbon-negative and high-rate nutrient removal using mixotrophic microalgae. Bioresource Technol 340.
[16] Song, Y., Mhuantong, W., Liu, S.Y., Pisutpaisal, N., Wongwilaiwalin, S., Kanokratana, P., Wang, A.J., Jiang, C.Y., Champreda, V., Qiu, D.R. and Liu, S.J.* 2021. Tropical and temperate wastewater treatment plants assemble different and diverse microbiomes. Appl Microbiol Biot 105(2), 853-867.
[17] Sun, F., Deng, Q.H., Li, X.W., Tang, M.J., Ma, X.F., Cao, X.Y., Zhou, Y.Y. and Song, C.L.* 2021. Organic carbon quantity and quality jointly triggered the switch between dissimilatory nitrate reduction to ammonium (DNRA) and denitrification in biofilters. Chemosphere 280.
[18] Tan, Q.Y., Chen, J.M., Chu, Y.F., Liu, W., Yang, L.L., Ma, L., Zhang, Y., Qiu, D.R., Wu, Z.B. and He, F.* 2021. Triclosan weakens the nitrification process of activated sludge and increases the risk of the spread of antibiotic resistance genes. J Hazard Mater 416.
[19] Tang, M.J., Deng, Q.H., Cao, X.Y., Zhou, Y.Y., Sun, Q.Y. and Song, C.L.* 2021. Mechanisms and risks of joint control of nitrogen and phosphorus through sediment capping technology in a pilot-scale study. J Soil Sediment 21(10), 3427-3437.
[20] Yang, L.1, Cao, X.Y.1, Chen, X.Y., Deng, Q.H., Wan, L.L., Li, X.W., Zhou, Y.Y. and Song, C.L.* 2021. Community composition and functional genes explain different ecological roles of heterotrophic bacteria attached to two bloom-forming cyanobacterial genera. Sci Total Environ 758.
[21] Zhang, M.Z., Xu, D.*, Bai, G.L., Cao, T.T., Liu, W., Hu, Z., Chen, D.S., Qiu, D.R. and Wu, Z.N. 2021. Changes of microbial community structure during the initial stage of biological clogging in horizontal subsurface flow constructed wetlands. Bioresource Technol 337.
[22] Zhang, Z.M., Deng, Q.H., Wan, L.L., Cao, X.Y., Zhou, Y.Y. and Song, C.L.* 2021. Bacterial communities and enzymatic activities in sediments of long-term fish and crab aquaculture ponds. Microorganisms 9(3).
[23] Zhang, Z.M., Deng, Q.H., Cao, X.Y., Zhou, Y.Y. and Song, C.L.* 2021. Patterns of sediment fungal community dependent on farming practices in aquaculture ponds. Front Microbiol 12.
2020年
[24] 刘亚琦，刘双元，高娜，戴景程，邱东茹*. 2020. 活性污泥菌胶团/生物絮团形成菌Pseudoduganella eburnean 的分离鉴定及基因组分析. 水生生物学报44(3):655-662.
[25] 邱东茹*. 2020.蓝藻胞外多聚物生物合成、群体形成与微囊藻水华. 水生生物学报44(5): 1008-1013.
[26] Chen, X.Y., Dolinova, I., Sevcu, A., Jurczak, T., Frankiewicz, P., Wojtal-Frankiewicz, A., Wan, L.L., Deng, Q.H., Song, C.L., Zhou, Y.Y. and Cao, X.Y.* 2020. Strategies adopted by Aphanizomenon flos-aquae in response to phosphorus deficiency and their role on growth. Environ Sci Eur 32(1).
[27] Dai, J.C., Dong, A.J.*, Xiong, G.X., Liu, Y.Q., Hossain, M.S., Liu, S.Y., Gao, N., Li, S.Y., Wang, J., Qiu, D.R.*. 2020. Production of highly active extracellular amylase and cellulase from Bacillus subtilis ZIM3 and a recombinant strain with a potential application in tobacco fermentation. Front Microbiol 11:1539.
[28] Deng, Q.H., Wan, L.L., Li, X.W., Cao, X.Y., Zhou, Y.Y. and Song, C.L.* 2020. Metagenomic evidence reveals denitrifying community diversity rather than abundance drives nitrate removal in stormwater biofilters amended with different organic and inorganic electron donors. Chemosphere 257.
[29] Han, F., Zhang, Y.*, Liu, Z.S., Wang, C., Luo, J., Liu, B.Y., Qiu, D.R., He, F. and Wu, Z.B. 2020. Effects of maifanite on growth, physiological and phytochemical process of submerged macrophytes Vallisneria spiralis. Ecotox Environ Safe 189.
[30] Li, S.Y., Zhao, L., Han, J.Y., Liu, S.Y., Dai, J.C., Fu, G.P. and Qiu, D.R.* 2020. Azoarcus halotolerans sp. nov., a novel member of Rhodocyclaceae isolated from activated sludge collected in Hong Kong. Int J Syst Evol Micr 70(11), 5799-5805.
[31] Li, X.W., Chai, X.J., Zheng, L.L., Deng, Q.H., Chen, X.Y., Zhang, Q., Wan, L.L., Song, C.L., Song, L.R., Zhou, Y.Y. and Cao, X.Y.* 2020. Coupling between benthic nutrient cycling and pelagic phytoplankton community in Taiwan Strait in spring 2018. J Mar Sci Eng 8(10).
[32] Lu, Z., Dai, J.C., Zheng, L.L., Teng, Z.R., Zhang, Q., Qiu, D.R., Song, L.R.* 2020. Disodium 2-oxoglutarate promotes carbon flux into astaxanthin and fatty acid biosynthesis pathways in Haematococcus. Bioresource Technol 299:122612.
[33] Rasulov, B.A.*, Dai, J.C., Pattaeva, M.A., Liu, Y.H., Yili, A., Aisa, H.A., Qiu, D.R. and Li, W.J. 2020. Gene expression abundance dictated exopolysaccharide modification in Rhizobium radiobacter SZ4S7S14 as the cell's response to salt stress. Int J Biol Macromol 164, 4339-4347.
[34] Tang, M.J., Deng, Q.H., Li, X.W., Cao, X.Y., Zhang, Z.M., Zhou, Y.Y., Sun, Q.Y. and Song, C.L.* 2020. The effect of natural materials used as sediment remediation on phosphorus and nitrogen control in a mesocosm. Environ Sci Eur 32(1).
[35] Cao, X.Y., Li, H., Zhou, Y.Y. and Song, C.L.* 2020. The shift of mutualistic relationships among algae, free-living and attached bacteria through different nutrient addition mode: a mesocosm study. J Freshwater Ecol 35(1), 535-548.
2019年
[36] 邱东茹*，高娜，安卫星，余佃贞，夏明. 2019. 活性污泥微生物胞外多聚物生物合成途径与菌胶团形成调控机制. 微生物学通报46(8): 2080-2089.
[37] 王晶，高娜，刘双元，戴景程，刘亚琦，邱东茹*. 2019. 活性污泥微生物解壳聚糖松江菌中菌胶团形成相关大型基因簇的鉴定和分析. 微生物学通报46(8): 1946-1953.
[38] Dai, J.C., Liu, Y.Q., Liu, S.Y., Li, S.Y., Gao, N., Wang, J., Zhou, J.Z. and Qiu, D.R.* 2019. Differential gene content and gene expression for bacterial evolution and speciation of Shewanella in terms of biosynthesis of heme and heme-requiring proteins. BMC Microbiol 19.
[39] Cao, X.Y., Chen, X.Y., Song, C.L.* and Zhou, Y.Y. 2019. Comparison of phosphorus sorption characteristics in the soils of riparian buffer strips with different land use patterns and distances from the shoreline around Lake Chaohu. J Soil Sediment 19(5), 2322-2329.
[40] Song, C.L., Cao, X.Y., Zhou, Y.Y., Azzaro, M., Monticelli, L.S., Maimone, G., Azzaro, F., La Ferla, R. and Caruso, G.* 2019. Nutrient regeneration mediated by extracellular enzymes in water column and interstitial water through a microcosm experiment. Sci Total Environ 670, 982-992.
[41] Wan, L.L., Chen, X.Y., Deng, Q.H., Yang, L., Li, X.W., Zhang, J.Y., Song, C.L., Zhou, Y.Y. and Cao, X.Y.* 2019. Phosphorus strategy in bloom-forming cyanobacteria (Dolichospermum and Microcystis) and its role in their succession. Harmful Algae 84, 46-55.
[42] Wan L.L., Cao, L., Cao, X.Y., Wang, Z.C., Zhou, Y.Y. and Song. C.L.* 2019. The optimized key parameters and their mechanisms for simultaneous nitrogen and phosphorus removal in stormwater biofilters: A pilot study. Environ Eng Sci 36(3): 372-383.
[43] Zhang, Y., Song, C.L.*, Zhou, Z.J., Cao, X.Y. and Zhou, Y.Y. 2019. Coupling between nitrification and denitrification as well as its effect on phosphorus release in sediments of Chinese shallow lakes. Water-Sui 11(9).
2018年
[44] Gao, N., Xia, M., Dai, J.C., Yu, D.Z., An, W.X., Li, S.Y., Liu, S.Y., He, P.H., Zhang, L.P., Wu, Z.B., Bi, X.Z., Chen, S.W., Haft, D.H. and Qiu, D.R.* 2018. Both widespread PEP-CTERM proteins and exopolysaccharides are required for floc formation of Zoogloea resiniphila and other activated sludge bacteria. Environ Microbiol 20(5), 1677-1692.
[45] Cao, X.Y., Song, C.L.*, Xiao, J. and Zhou Y.Y. 2018. The optimal width and mechanism of riparian buffers for storm water nutrient removal in the Chinese eutrophic Lake Chaohu watershed. Water 1489:1-11.
[46] Cao, X.Y., Wan, L.L., Xiao, J., Chen, X.Y., Zhou, Y.Y., Wang, Z.C. and Song, C.L.* 2018. Environmental effects by introducing Potamogeton crispus to recover a eutrophic Lake. Sci Total Environ 621, 360-367.
[47] Song, C.L., Cao, X.Y., Zhou, Y.Y., Azzaro, M., Monticelli, L.S., Leonardi, M., La Ferla, R. and Caruso, G.* 2018. Different pathways of nitrogen and phosphorus regeneration mediated by extracellular enzymes in temperate lakes under various trophic state. Environ Sci Pollut R 25(31), 31603-31615.
[48] Song, C.L., S？ndergaard, M., Cao, X.Y. and Zhou, Y.Y.* 2018. Nutrient utilization strategies of algae and bacteria after the termination of nutrient amendment with different phosphorus dosage: A mesocosm case. Geomicrobiol J 35(4), 294-299.
[49] Wang, S.Y., Xiao, J., Wan, L.L., Zhou, Z.J., Wang, Z.C., Song, C.L., Zhou, Y.Y. and Cao, X.Y.* 2018. Mutual dependence of nitrogen and phosphorus as key nutrient elements: One facilitates Dolichospermum flos-aquae to overcome the limitations of the other. Environ Sci Technol 52(10), 5653-5661.
[50] Xiao, J., Wang, S.Y., Zhou, Z.J., Zhang, Y., Song, C.L.*, Zhou, Y.Y.* and Cao, X.Y.* 2018. An enzymatic mechanism for balancing the stoichiometry of nitrogen and phosphorus in a shallow Chinese eutrophic lake. Sci Total Environ 630, 1071-1077.
[51] Zhang, Y., Song, C.L., Ji, L., Liu, Y.Q., Xiao, J., Cao, X.Y.* and Zhou, Y.Y. * 2018. Cause and effect of N/P ratio decline with eutrophication aggravation in shallow lakes. Sci Total Environ 627, 1294-1302.
发明专利
[1] 邱东茹，李书杨，刘双元. 一种海洋来源耐盐菌胶团形成菌新种及其应用，CN20210724565.4，2022，发明专利。
[2] 邱东茹，戴景程，周集中. 一株高产血红素的洛伊希瓦氏菌基因工程菌及其构建方法，CN201910072760.6，2021，发明专利。
[3] 邱东茹，刘双元，高娜，戴景程，李书杨. 一种移动式净化污水和黑臭水体的方法及装置，CN20180895621.9，2021，发明专利。
[4] 宋春雷，曹秀云，周易勇，张志敏. 一种沉积物修复技术应用的筛选方法，CN111189958B， 2021，发明专利。
[5] 宋春雷，张志敏，曹秀云，周易勇. 一种基于污染拦截的缓冲带构建模式与宽度划定方法，CN111153500A，2020，发明专利。
[6] 宋春雷，周易勇，曹秀云，汪志聪，周子俊. 一种高效脱氮除磷的土地处理方法及系统，CN102923783B，2019， 发明专利。
[7] 宋春雷，周易勇，曹秀云，汪志聪. 一种用于迎风面堤岸的基底改善与生态修复方法，CN106223265B，2018，发明专利。
[8] 邱东茹，夏明，柏仕杰. 一种杀藻剂在控制微囊藻水华中的用途，CN201310669686.9，2016，发明专利。
