学科带头人：胡晗华 研究员 

　　学科组成员：潘玉芳实验师、研究生5人。 

　　学科组介绍：硅藻是藻类中的一个重要类群，作为主要的初级生产者，约占全球初级生产的五分之一，相当于整个热带雨林的净初级生产量，是当代海洋中最为成功的真核藻类群体之一（占海洋初级生产的40%）；硅藻也广泛分布于淡水环境中，特别是在温度较低的春季和秋季易形成优势。硅藻在水生生态系统碳、氮和硅的生物地球化学循环中起着重要的作用。此外，由于硅藻的同化产物主要是油，而被认为是最为合适的生物柴油原料之一。该学科组主要以三角褐指藻为模式研究硅藻对环境的适应策略及利用硅藻产油的生物技术。 

　　近期部分论文（*示通讯作者）： 

1. Rastogi A, Vieira FRJ, Deton-Cabanillas A-F, Veluchamy A, Cantrel C, Wang G, Vanormelingen P, Bowler C, Piganeau G, Hu H*, Tirichine L*. A genomics approach reveals the genetic polymorphism, structure and functional diversity of ten accessions of the diatom Phaeodactylum tricornutum. The ISME Journal. 2020, 14: 347-363.
2. Chen Y, Hu H*. High efficiency transformation by electroporation of the freshwater alga Nannochloropsis limnetica. World Journal of Microbiology & Biotechnology. 2019, 35(8): 119.
3. Li X, Pan Y, Hu H*. Identification of the triacylglycerol lipase in the chloroplast envelope of the diatom Phaeodactylum tricornutum. Algal Research. 2018, 33: 440-447.
4. Pan Y, Yang J, Gong Y, Li X, Hu H*. 3-hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum. Philosophical Transactions of the Royal Society B‐Biological Sciences. 2017, 372(1728): 20160409.
5. Schoefs B*, Hu H*, Kroth PG*. The peculiar carbon metabolism in diatoms. Philosophical Transactions of the Royal Society B‐Biological Sciences. 2017, 372(1728): 20160405.
6. Wei L, Xin Y, Wang Q, Yang J, Hu H*, Xu J*. RNAi-based targeted gene-knockdown in the model oleaginous microalgae Nannochloropsis oceanica. The Plant Journal. 2017, 89(6): 1236-1250.
7. Yang J, Pan Y, Bowler C, Zhang L, Hu H*. Knockdown of phosphoenolpyruvate carboxykinase increases carbon flux to lipid synthesis in Phaeodactylum tricornutum. Algal Research. 2016, 15: 50-58.
8. Ge F, Huang W, Chen Z, Zhang C, Xiong Q, Bowler C, Yang J, Xu J, Hu H*. Methylcrotonyl-CoA carboxylase regulates triacylglycerol accumulation in the model diatom Phaeodactylum tricornutum. The Plant Cell. 2014, 26(4): 1681-1697. (*Corresponding author)
9. Zhang C, Hu H*. High-efficiency nuclear transformation of the diatom Phaeodactylum tricornutum by electroporation. Marine Genomics. 2014, 16: 63-66.
10. Gong Y, Hu H*. Effect of silicate and inorganic carbon availability on the growth and competition of a diatom and two red-tide dinoflagellates. Phycologia. 2014, 53(5): 433-442.
11. Li F, Gao D, Hu H*. High-efficiency nuclear transformation of the oleaginous marine Nannochloropsis species using PCR product. Bioscience Biotechnology and Biochemistry. 2014, 78(5): 812-817.
12. Gong Y, Wan X, Jiang M, Hu C, Hu H, Huang F. Metabolic engineering of microorganisms to produce omega-3 very long-chain polyunsaturated fatty acids. Progress in Lipid Research. 2014, 56: 19-35.
13. Xu J, Hu H*. Screening high oleaginous Chlorella strains from different climate zones. Bioresource Technology. 2013, 144: 637-643.
14. Zha S, Xu X, Hu H*. A high sensitivity iron-dependent bioreporter used to measure iron bioavailability in freshwaters. FEMS Microbiology Letters. 2012, 334(2): 135-142.
15. Chen Z, He C, Hu H*. Temperature responses of growth, photosynthesis, fatty acid and nitrate reductase in Antarctic and temperate Stichococcus. Extremophiles. 2012, 16(1): 127-133.
16. Allen AE, Dupont CL, Oborník M, Horák A, Nunes-Nesi A, McCrow JP, Zheng H, Johnson DA, Hu H, Fernie AR, Bowler C. Evolution and metabolic significance of the urea cycle in photosynthetic diatoms. Nature. 2011, 473(7346): 203-207.
17. Hu H*, Zhang J, Chen W. Competition of bloom-forming marine phytoplankton at low nutrient concentrations. Journal of Environmental Sciences. 2011, 23(4): 656-663.
18. Maumus F, Allen AE, Mhiri C, Hu H, Jabbari K, Vardi A, Grandbastien M-A, Bowler C. Potential impact of stress activated retrotransposons on genome evolution in a marine diatom. BMC Genomics. 2009, 10: 624.
19. Hu H*, Li H, Xu X. Alternative cold response modes in Chlorella (Chlorophyta, Trebouxiophyceae) from Antarctica. Phycologia. 2008, 47(1): 28-34.
20. Zhang X, Hu H*, Tan T. Photosynthetic inorganic carbon utilization of gametophytes and sporophytes of Undaria pinnatifida (Phaeophyceae). Phycologia. 2006, 45(6): 642-647.
21. Hu H*, Chen W, Shi Y, Cong W. Nitrate and phosphate supplementation to increase toxin production by the marine dinoflagellate Alexandrium tamarense. Marine Pollution Bulletin. 2006, 52(7): 756-760.
22. Hu H*, Gao K. Response of growth and fatty acid compositions of Nannochloropsis sp. to environmental factors under elevated CO₂ concentration. Biotechnology Letters. 2006, 28(13): 987-992.
23. Hu H*, Shi Y, Cong W. Improvement in growth and toxin production of Alexandrium tamarense by two-step culture method. Journal of Applied Phycology. 2006, 18(2): 119-126.
24. Shi Y, Hu H*, Cong W. Positive effects of continuous low nitrate levels on growth and photosynthesis of Alexandrium tamarense (Gonyaulacales, Dinophyceae). Phycological Research. 2005, 53(1): 43-48.
25. Shi Y, Hu H*, Ma R, Cong W, Cai Z. Improved use of organic phosphate by Skeletonema costatum through regulation of Zn²⁺ concentrations. Biotechnology Letters. 2004, 26(9): 747-751.
26. Hu H*, Shi Y, Cong W, Cai Z. Growth and photosynthesis limitation of marine red tide alga Skeletonema costatum by low concentrations of Zn²⁺. Biotechnology Letters. 2003, 25(22): 1881-1885.
27. Hu H, Gao K. Optimization of growth and fatty acid composition of a unicellular marine picoplankton, Nannochloropsis sp., with enriched carbon sources. Biotechnology Letters. 2003, 25(5): 421-425.