杰出青年
姓 名: 张承才
性 别:
职 称: 研究员
电 话: 86-27-68780989
电子邮件: cczhang#ihb.ac.cn

简历介绍:

研究员,博士生导师;1984年毕业于山东师范大学,获学士学位;后留学于法国艾克斯马赛第二大学,1989年获法国国家博士学位;1989-1991于瑞士苏黎士大学从事博士后研究;1991-1999年任法国斯特拉斯堡市路易巴斯德大学讲师;1999-2015年任法国艾克斯马赛第二大学教授、一级教授级及特级教授;2008-2012年任法国艾克斯马赛第二大学理学院副院长、院长;2012-2015任法国艾克斯马赛大学理学院副院长;2015年7月加入中国科学院水生生物研究所;2017年起担任中国科学院藻类生物学重点实验室主任。 

2008-2014年任英国皇家微生物学协会期刊Microbiology执行编辑;2008年至今任美国微生物学协会期刊Journal of Bacteriology编委,并于2015被选为top-performing reviewer members之一;2012年至今为国务院侨办海外专家委员会委员;2011年1月-2014年1月担任欧洲科学基金会(ESF)-EMBO蓝细菌生物能学系列研讨会担任过副主席及主席;2020年至今担任美国微生物学会(American Society for Microbiology)会员;2021年起至今任国际光合原核微生物研讨会(ISPP)国际学术委员会成员并担任2025年ISPP会议主席;2023年起至今任中国微生物学会永久会员;2023年起至今任洪山实验室固定研究人员;2022年起至今任Anual Review of Microbiology编委。 

长期从事原核生物细胞发育、信号传导等基础生物学研究。以蓝细菌为材料,研究了细菌中真核类激酶、磷酸酶的在细胞发育中的生理功能;证明了酮戊二酸(2-OG)是蓝细菌细胞感受缺氮并起始异形胞分化的信号分子;对氮代谢调控全局性转录因子NtcA蛋白晶体结构分析证明NtcA是2-OG的受体,从而解释了2-OG信号传递的机制。 

研究方向:

藻类生物学,环境微生物学,分子生物学。 

社会任职:

 

获奖及荣誉:

2014年获得法国教育科学部骑士勋章(Chevalier dans l’Ordre Acad mique)。

2024年获得留法校友会华中区杰出校友奖。

代表论著:

1. Ye-Jun Peng, Yuxing Chen, Cong-Zhao Zhou, Wei Miao, Yong-Liang Jiang*, Xiaoli Zeng* and Cheng-Cai Zhang* (2024) Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains. Structure. 32(1-13):e1-e4. 

2. Qin-Xue Sun, Min Huang, Ju-Yuan Zhang, Xiaoli Zeng*, Cheng-Cai Zhang* (2023) Control of Cell Size by c-di-GMP Requires a Two-Component Signaling System in the Cyanobacterium Anabaena sp. Strain PCC 7120. Microbiology Spectrum. 10.1128. 

3. Xiaoli Zeng, Min Huang, Qing-Xue Sun, Ye-Jun Peng, Xiaomei Xu, Yun-Bin Tang, Ju-Yuan Zhang, Yiling Yang, Cheng-Cai Zhang* (2023) A c-di-GMP binding effector controls cell size in a cyanobacterium. PNAS. 120(13):e2221874120. 

4. Zi-Qian Wang, Yiling Yang, Ju-Yuan Zhang, Xiaoli Zeng, Cheng-Cai Zhang* (2023) Global translational control by the transcriptional repressor TrcR in the filamentous cyanobacterium Anabaena sp. PCC 7120. Communications Biology. 6:643. 

5. Wei-Yue Xing, Jing Liu, Cheng-Cai Zhang* (2023) HetF defines a transition point from commitment to morphogenesis during heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120. Molecular Microbiology. 00:740-753. 

6. Su-Juan Liu, Gui-Ming Lin, Yu-Qi Yuan, Wen-Li Chen, Juyuan Zhang*, Cheng-Cai Zhang* (2023) A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria. Nucleic Acids Research. 1-16. 

7. Jing Liu, Wei-Yue Xing, Bowen Liu, Cheng-Cai Zhang* (2023) Three-dimensional coordination of cell-division site positioning in a filamentous cyanobacterium. PNAS nexus. 10.1093. 

8. Ziqian Wang, Suqin Wang, Ju-Yuan Zhang, Gui-Ming Lin, Nanqin Gan, Lirong Song, Xiaoli Zeng, Cheng-Cai Zhang* (2023) Investigation on cyanobacterial production of the proposed neurotoxin -N-methylamino-L-alanine (BMAA). Water Biol. Security. P 100208. 

9. Wei-Yue Xing, Jing Liu, Ju-Yuan Zhang, Xiaoli Zeng, Cheng-Cai Zhang* (2022) A proteolytic pathway coordinates cell division and heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120. PNAS. 119 (36):e2207963119. 

10. Xiaoli Zeng*, Cheng-Cai Zhang* (2022) The making of a heterocyst in cyanobacteria. Annu Rev Microbiol. 76:597-618. 

11. JuYuan Zhang, Wolfgang R. Hess*, Cheng-Cai Zhang* (2022) “Life is short, and art is long”: RNA degradation in cyanobacteria and model bacteria. mLife. 00(00):1-19. 

12. Zi-Qian Wang, Cheng-Cai Zhang* (2022) A tRNA t6A modification system contributes to the sensitivity towards the toxin -N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120. Aquatic Toxicology. 245:106121. 

13. Ju-Yuan Zhang, Tian-Cai Niu, Gui-Ming Lin, Cheng-Cai Zhang (2022) A CRISPR-Based Method for Constructing Conditional Mutations of Essential Genes in Cyanobacteria. Essential Genes and Genomes. Part of the Methods in Molecular Biology book series (MIMB, volume 2377). pp 143-157. 

14. Min Huang, Ju-Yuan Zhang, Xiaoli Zeng* and Cheng-Cai Zhang (2021) c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120 Frontiers in Microbiology. 12:793336. 

15. Wei-Yue Xing, Jing Liu, Zi-Qian Wang, Ju-Yuan Zhang, Xiaoli Zeng, Yiling Yang and Cheng-Cai Zhang* (2021) HetF protein is a new divisome component in a filamentous and developmental cyanobacterium. mBio. 12:e01382-21. 

16. Li Wang, Tian-Cai Niu, Ana Valladares, Gui-Ming Lin, Ju-Yuan Zhang, Antonia Herrero*, Wenli Chen*, Cheng-Cai Zhang* (2021) The developmental regulator PatD modulates assembly of the cell-division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120. Environmental Microbiology. 23(8):4823-4837. 

17. Jing Liu, Wei-Yue Xing, Ju-Yuan Zhang, Xiaoli Zeng , Yiling Yang and Cheng-Cai Zhang* (2021) Functions of the Essential GenemraY in Cellular Morphogenesis and Development of the Filamentous Cyanobacterium Anabaena PCC 7120. Frontiers in Microbiology. 12:765878. 

18. Zi-Qian Wang, Suqin Wang, Ju-Yuan Zhang, Gui-Ming Lin, Nanqin Gan , Lirong Song, Xiaoli Zeng* a Cheng-Cai Zhang* (2020) The proposed neurotoxin -n-methylamino-l-alanine (bmaa) is taken up through amino-acid transport systems in the cyanobacterium anabaena pcc 7120. Toxins. 12(8):518. 

19. Wei-Yue Xing, Li-rui Xie, Xiaoli Zeng, Yiling Yang* and Cheng-Cai Zhang* (2020) Functional dissection of genes encoding dna polymerases based on conditional mutants in the heterocyst-forming cyanobacterium anabaena pcc 7120. Frontiers in Microbiology. 11:1108. 

20. Li Wang, Tian-Cai Niu, Gui-Ming Lin, Shao-Ran Zhang, Ju-Yuan Zhang, Guo-Fang Tang, Wenli Chen*, Cheng-Cai Zhang* (2019) patD, a gene regulated by NtcA, is involved in the optimization of heterocyst frequency in the cyanobacterium Anabaena PCC 7120. J. Bacteriol. 201(21). pii:e00457-19. 

21. Wei-Yue Xing, Cheng-Cai Zhang* (2019) Preventing accidental heterocyst development in cyanobacteria. J. Bacteriol. 201 (17):e00349-19. 

22. Tian-Cai Niu, Gui-Ming Lin, Li-Rui Xie, Zi-Qian Wang, Wei-Yue Xing, Ju-Yuan Zhang*, Cheng-Cai Zhang (2019) Expanding the potential of CRISPR-Cpf1 based genome editing technology in the cyanobacterium Anabaena PCC 7120. ACS Synth. Biol. 8:170-180. 

23. Cheng-Cai Zhang*, Cong-Zhao Zhou, Robert L. Burnap, Ling Peng (2018) Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Sci. 23:1116-1130. 

24. Yali Wang, Yuan Gao, Chao Li, Hong Gao, Cheng-Cai Zhang and Xudong Xu* (2018) Three substrains of the cyanobacterium Anabaena sp. PCC 7120 display divergence in genomic sequences and hetC function, J. Bacteriol. 200 (13):e00076-18. 

25. Ju-Yuan Zhang, Gui-Min Lin, Wei-Yue Xin and Cheng-Cai Zhang* (2018) Diversity of the growth patterns probed in live cyanobacterial cells using a fluorescent analog of a peptidoglycan precursor. Frontiers in Microbiology. 9:791. 

26. Yong-Liang Jiang, Xue-Ping Wang, Hui Sun, Shu-Jing Han, Wei-Fang Li, Ning Cui, Gui-Ming Lin, Ju-Yuan Zhang, Wang Cheng , Dong-Dong Cao , Zhi-Yong Zhang, Cheng-Cai Zhang*, Yuxing Chen*, Cong-Zhao Zhou* (2018) Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. PNAS. 115:403-408. 

27. Cheng, Y., Schorey, JS., Zhang, C.-C.., and Tan X. (2017) Protein kinase inhibitors as potential antimicrobial drugs against Tuberculosis, Malaria and HIV. Curr. Pharm. Des. 23:4369-4389. 

28. Fan Y, Lemeille, S., Gonz lez, A., Risoul, V., Denis, Y., Richaud, P., Lamrabet, O., Fillat, M., Zhang, C.-C., Latifi A. (2015) The Pkn22 Ser/Thr kinase in Nostoc PCC 7120: role of FurA and NtcA regulators and transcript profiling under nitrogen starvation and oxidative stress. BMC Genomics. 16:557. 

29. Hu, H-X., Jiang, Y-L., Zhao, M-X., Cai K., Liu, S., Wen, B., Lv, P., Zhang, Y., Peng, J., Yu, H.-M., Ren, Y.-M., Zhang, Z., Wu, Q., Oliveberg, M., Zhang, C.-C.*., Chen, Y*., Zhou, C.Z.* (2015) Structural insights into HetR PatS interaction involved in cyanobacterial pattern formation. Sci. Rep. 5:16470. 

30. Zhang, J-Y; Deng, X-M; Li, F-P; Wang, L; Huang, Q-Y; Zhang, C.-C.; Chen, W-L. (2014) RNase E, via a cyanobacterial-specific nonapeptide in the non-catalytic domain, forms a complex with polynucleotide phosphorylase in cyanobacteria. RNA. 20:568-579. 

31. Liu X, Wang Y, Laurini E, Posocco P, Chen H, Ziarelli F, Janicki A, Qu F, Fermeglia M, Pricl S, Zhang C.-C., Peng L. (2013) Structural requirements of molecular probes to mimic the signalling function of 2-oxoglutaric acid, a key Krebs cycle intermediate. Org Lett. 15:4662-4665.  

32. Zhang S-R, Lin G-M, Chen W-L, Wang L, Zhang C-C (2013) ppGpp metabolism is involved in heterocyst development in the cyanobacterium Anabaena sp. PCC 7120. J. Bacteriol. 195:4536-4544. 

33. Zhang C.-C. & Zhou C-Z. (2013) ATPase as a switch in PII signal transduction. PNAS.  110:12863-12864. 

34. Boileau, C., Eme, L., Brochier-Armanet, C., Janicki, A., Zhang, C.-C. and Latifi A. (2011) A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2-Cys peroxiredoxin in the cyanobacterium Anabaena PCC 7120. New Phytologist 191:1108–1118. 

35. Liu, X., Chen, H., Laurini, E., Wang, Y., Dal Col, V., Posocco, P., Ziarelli, F., Fermeglia, M., Zhang, C.-C., Pricl, S., and Peng, L. (2011) 2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria. Org. Lett. 13:2924-2927. 

36. Bastet, L., Boileau, C., Janicki, A., Bedu, S., Latifi, A. and Zhang, C.-C. (2010) NtcA regulates patA expression in Anabaena sp. strain PCC 7120. J. Bacteriol. 192:5257-5259. 

37. Janssen, P.J., Morin, N., Mergeay, M., Leroy, B., Wattiez, R., Vallaeys, T., Waleron, R., Waleron, M., Wilmotte, A., Quillardet, P., Tandeau de Marsac, N., Talla, E., Zhang, C.-C. and Leys, N. (2010) Genome Sequence of the Edible Cyanobacterium Arthrospira sp. PCC 8005. J. Bacteriol. 192:2465-2466. 

38. Zhao, M.-X., Jiang, Y.-L., He, Y.-X., Chen, Y.-F., Teng, Y.-B., Chen, Y., Zhang, C.-C.*, and Zhou, C.-Z.* (2010) Structural basis for the allosteric control of the global nitrogen-regulating transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. *Co-corresponding authors. PNAS. 107:12487-12492. 

39. Jang, J., Shi, L., Tan, H., Janicki, A., and Zhang, C.-C.* (2009) Mutual regulation of ntcA and hetR during heterocyst differentiation requires two similar PP2C-type protein phosphatases PrpJ1 and PrpJ2 in Anabaena sp. strain PCC 7120. J. Bacteriol. 191:6059-6066. 

40. Latifi, A., Ruiz, M. and Zhang, C.-C. (2009) Oxidative stress in cyanobacteria. FEMS Microbiol. Rev., 33:258-278. 

41. Zhang, L.-C., Chen, Y.-F., Chen, W.-L., and Zhang, C.-C.* (2008) Existence of periplasmic barriers preventing GFP diffusion from cell to cell in the cyanobacterium Anabaena sp. strain PCC 7120. Mol Microbiol. 70:814-823. 

42. Jeanjean, R., Talla, E., Latifi, A., Havaux, M., Janicki, A., and Zhang, C.-C.* (2008) A large gene cluster encoding peptide synthetases and polyketide synthases is involved in production of siderophores and oxidative-stress response in the cyanobacterium Anabaena sp. strain PCC 7120. Environ. Microbiol. 10:2574-2585. 

43. Shi, L., Li, J.-H.,, Cheng, Y., Wang, L., Chen W.L. & Zhang, C.-C.* (2007) Two genes encoding protein kinases of the HstK family are involved in the synthesis of the minor heterocyst-specific glycolipid in the cyanobacterium Anabaena sp. strain PCC 7120. J. Bacteriol., 189:5075-5081. 

44. Jang, J., Wang, L., Jeanjean, R. & Zhang, C.-C.* (2007) PrpJ, a PP2C-type protein phosphatase located on the plasma membrane, is involved in heterocyst maturation in the cyanobacterium Anabaena sp. PCC 7120. Mol. Microbiol. 64:247-358. 

45. Latifi, A, Ruiz, M., Jeanjean, R. & Zhang, C.-C. (2007) PrxQ-A, a member of the peroxiredoxin Q family, plays a major role in defense against oxidative stress in the cyanobacterium Anabaena sp. PCC 7120. Free Radical Biol. Med. 42:424-431. 

46. Chen, H., Laurent, S., B du, S., Ziarelli, F., Cheng, Y., Zhang, C.-C. & Peng, L. (2006) Studying the signaling role of 2-oxoglutaric acid by using analogues that mimic the ketone and ketal forms of 2-oxoglutaric acid. Chemistry & Biology. 13:849-856. 

47. Sakr, S., Thyssen, M., Denis, M. & Zhang, C.-C.* (2006) Relationship among several key cell-cycle events in the developmental cyanobacterium Anabaena sp. strain PCC 7120. J. Bacteriol. 188:5958-5965. 

48. Cheng, Y., Li, J-H., Shi., L., Wang, L., Latifi, A., & Zhang, C.-C.* (2006) A pair of iron-responsive genes encoding protein kinases with a Ser/Thr-kinase domain and a His-kinase domain are regulated by NtcA in the cyanobacterium Anabaena sp. strain PCC 7120. J. Bacteriol. 188:4822-4829. 

49. Sakr, S., Jeanjean, R., Zhang, C.-C.*, & Arcond guy, T. (2006) Inhibition of cell division suppresses heterocyst development in Anabaena sp. strain PCC 7120. J. Bacteriol. 188:1396-1404. 

50. Zhang, C.-C.*, Laurent, S., Sakr, S., Peng, L. & B du, S. (2006) Heterocyst differentiation and pattern formation in cyanobacteria: a chorus of signals. Mol. Microbiol. 59:367-375. 

51. Latifi, A., Jeanjean, R., Lemeille, S., Havaux, M. & Zhang, C.-C. (2005) Iron starvation leads to oxidative stress in Anabaena sp. strain PCC 7120. J. Bacteriol. 187:6596-6598. 

52. Laurent, S., Chen, H., B du, S., Ziarelli, F., Peng, L* & Zhang, C.-C.* (2005) Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. strain PCC 7120. PNAS. 102:9907-9912. 

53. Kuhn, I., Peng, L., B du, S. & Zhang, C.-C.* (2000) Developmental regulation of the cell division protein FtsZ in Anabaena sp. strain PCC 7120, a cyanobacterium capable of terminal differentiation. J. Bacteriol. 182:4640-4643. 

54. Zhang, C.-C.*, Gonzalez, L. & Phalip, V. (1998) Survey, analysis and genetic organization of genes encoding eukaryotic-like signalling proteins by a cyanobacterial genome. Nucl. Acids Res. 26:3619-3625. 

55. Zhang, C.-C.*, Friry, A. & Peng, L. (1998) Molecular and genetic analysis of two closely linked genes that encode, respectively, a protein phosphatase 1/2A/2B homolog and a protein kinasehomolog in the cyanobacterium Anabaena sp. strain PCC 7120. J. Bacteriol. 180:2616-2622. 

56. Zhang, C.-C.* (1996) Bacterial signalling involving eukaryotic-type protein kinases. Mol. Microbiol. 20:9-15. 

57. Zhang, C.-C.* (1993) A gene encoding a protein related to eukaryotic-type protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120. PNAS. 90:11840-11844. 

58. Zhang, C-C. & Bienz, M. (1992) Segmental determination in Drosophila conferred by hunchback (hb), a repressor of the homeotic gene Ultrabithorax (Ubx). PNAS. 89:7511-7515. 

59. Zhang, C-C., Durand, M-C., Jeanjean, R. & Joset, F. (1989) Molecular and genetic analysis of the glucose-fructose transport system in the cyanobacterium Synechocystis PCC6803. Mol.  Microbiol. 3:1221-1229. 

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