| 姓 名： | 孙永华 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | 86-27-68780235 |
| 电子邮件： | yhsun@ihb.ac.cn |
简历介绍：
孙永华，1976年生，博士，中国科学院水生生物研究所研究员，博士生导师，国家杰出青年科学基金和优秀青年科学基金获得者，鱼类发育与生物技术学科组组长，国家水生生物种质资源库主任，国家斑马鱼资源中心主任。1997年于武汉大学获理学学士学位；2002年于中国科学院研究生院获理学博士学位；2006年9月-2008年3月获法中科学及应用基金会（FFCSA）奖励在法国国家科研中心IGBMC从事博士后研究；2009年10-12 月以客座副教授身份在美国弗吉尼亚大学进行合作研究。
主要从事鱼类生殖细胞发育与前沿育种技术研究。揭示了若干调控鱼类生殖细胞发育的关键因子及其作用机制；首次实现鱼类基因编辑配子的借腹生殖（也称“借腹怀胎”）前沿育种技术的突破；受命从零开始建成了全球三大库之一的国家斑马鱼资源中心（http://zfish.cn），牵头完成“斑马鱼1号染色体全基因敲除计划”，相关成果入选国家“十三五”科技创新成就展。先后主持国家重点研发计划“发育编程及其代谢调节”重点专项等一批科研项目。在Advanced Science、Genome Research、 Nature Communications、PLOS Biology、Development以及Cell Research、Science Bulletin、Science China-Life Sciences等国内外学术刊物上发表论文100 余篇。相关论文入选Springer Nature年度亮点论文，被Faculty of 1000专门推荐等。
研究方向：
鱼类生殖细胞发育与定向育种
社会任职：
国际斑马鱼学会理事
中国动物学会理事，斑马鱼分会副理事长兼秘书长，发育生物学分会理事
中国水产学会水产生物技术与遗传育种专业委员会委员
获奖及荣誉：
2021：中国动物学会，长隆奖新星奖
2019：中国科学院水生生物研究所，重要贡献奖
2016：中国科学院，青年创新促进会优秀会员
2016：首届中国水产，青年科技奖
2010：中国科学院，卢嘉锡青年人才奖
代表论著：
1) Zhang, R., Tu, Y.X., Ye, D., Gu, Z., Chen, Z.X.*, and Sun, Y.* (2022). A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Advanced Science 9, e2203631. 10.1002/advs.202203631. (back Cover paper)
2) He, M., Jiao, S., Zhang, R., Ye, D., Wang, H., and Sun, Y.* (2022). Translational control by maternal Nanog promotes oogenesis and early embryonic development. Development 149. 10.1242/dev.201213. (Research Highlight accompanied with Editor’s recommendation article)
3) Wang, Y., Ye, D., Zhang, F., Zhang, R., Zhu, J., Wang, H., He, M., and Sun, Y.* (2022). Cyp11a2 Is Essential for Oocyte Development and Spermatogonial Stem Cell Differentiation in Zebrafish. Endocrinology 163. 10.1210/endocr/bqab258.
4) Zhang, F., Hao, Y., Li, X., Li, Y., Ye, D., Zhang, R., Wang, X., He, M., Wang, H., Zhu, Z., and Sun, Y.* (2022). Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation. Science China. Life sciences 65, 969-987. 10.1007/s11427-021-1989-9.
5) Mohammed, Y., Ye, D., He, M., Wang, H., Li, Y., Han, D., Zhu, Z., and Sun, Y.* (2021). Induction of biosynthesis of ketocarotenoid from β-carotene in fish embryos. Aquaculture 542, 736863. 10.1016/j.aquaculture.2021.736863.
6) He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., and Sun, Y.* (2020). Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLOS Biology 18, e3000561.
7) Zhang, Q., Ye, D., Wang, H., Wang, Y., Hu, W., and Sun, Y.* (2020). Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction. Endocrinology 161, DOI:10.1210/endocr/bqaa048 (top cited paper in the year 2020, 2021, and 2022)
8) Zhang, F., Li, X., He, M., Ye, D., Xiong, F., Amin, G., Zhu, Z., and Sun, Y.* (2020). Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells. Journal of Genetics and Genomics 47, 37-47. (Recommended by Faculty of 1000)
9) Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., et al. (2020). Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome Research 30, 118–126.
10) Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y.*, and Zhang, Y.-A*. (2020). A critical role of foxp3a-positive Treg cells in maintaining immune homeostasis in zebrafish testis development. Journal of Genetics and Genomics. DOI: 10.1016/j.jgg.2020.07.006 (Cover paper)
11) Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., and Sun, Y.* (2019). Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLOS Genetics 15, e1008306.
12) Sun, Y.*, and Zhu, Z. (2019). Designing future farmed fishes using genome editing. Science China Life sciences 62, 420-422.
13) Ye, D., Zhu, L., Zhang, Q., Xiong, F., Wang, H., Wang, X., He, M., Zhu, Z., and Sun, Y.* (2019). Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline. Mar Biotechnol (NY) 21, 217-228. (Springer Nature 2019 Highlights)
14) Zhang, X., Pang, S., Liu, C., Wang, H., Ye, D., Zhu, Z., and Sun, Y.* (2019). A Novel Dietary Source of EPA and DHA: Metabolic Engineering of an Important Freshwater Species-Common Carp by fat1-Transgenesis. Mar Biotechnol (NY) 21, 171-185.
15) Sun, Y.-H.* (2017). Genome editing opens a new era for physiological study and directional breeding of fishes. Science Bulletin 62, 157-158.
16) Ye, D., Zhu, Z., and Sun, Y.* (2015). Fish genome manipulation and directional breeding. Science China Life sciences 58, 170-177.
17) Lu, F.I.#, Sun, Y.H.#, Wei, C.Y., Thisse, C., and Thisse, B. (2014). Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway. Nature Communications 5, 5368. (# co-first author)
18) Pang, S.C., Wang, H.P., Li, K.Y., Zhu, Z.Y., Kang, J.X., and Sun, Y.H.* (2014). Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model. Mar Biotechnol (NY) 16, 580-593.
19) Sun, Y.H.*, and Zhu, Z.Y. (2014). Cross-species cloning: influence of cytoplasmic factors on development. Journal of physiology (Lodon) 592, 2375-2379.
20) Wei, C.Y., Wang, H.P., Zhu, Z.Y., and Sun, Y.H.* (2014). Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5. The Journal of biological chemistry 289, 6604-6618.
21) Xiong, F., Wei, Z.Q., Zhu, Z.Y., and Sun, Y.H.* (2013). Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems. Mar Biotechnol (NY) 15, 526-539.
22) Sun, Y. H., Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2005). Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs. Biology of Reproduction 72, 510-515.
23) Wu, B.#, Sun, Y. H.#, Wang, Y. W., Wang, Y. P. and Zhu, Z. Y. (2005). Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.). Cell Research 15, 447-454.
24) Sun, Y., Chen, S., Wang, Y. and Zhu, Z. (2000). The onset of foreign gene transcription in nuclear-transferred embryos of fish. Science China Life Sciences 43, 597-605.
25) Zhu, Z. Y. and Sun, Y. H. (2000). Embryonic and genetic manipulation in fish. Cell Research 10, 17-27.
发明专利目录：
1) 叶鼎，孙永华，张泉清，何牡丹，王厚鹏。一种可标记鱼类生殖干细胞的多克隆抗体的制备方法，授权日期：2022年10月11日，专利号：ZL202110408610.5
2) 熊凤，孙永华，叶鼎，朱作言. 一种用于原始生殖细胞靶向突变的转基因载体及制备方法和用途. 2019年中国发明专利授权，专利号：ZL 201510809203.X
3) 孙永华，庞少臣，康景轩，朱作言.一种提高鱼类omega-3多不饱和脂肪酸的方法及应用. 2016年中国发明专利授权，专利号：ZL 201410155088.4
4) 孙永华，熊凤，魏志强，朱作言. 一种定向筛选同源重组PGC的载体及构建方法和应用. 2015年中国发明专利授权，专利号：ZL 201310341471.4
5) 孙永华, 朱作言, 熊凤, Ishtiaq Ahmed, Mike Waters. 一种鱼类持续激活生长激素受体基因及制备方法和用途. 2013年中国发明专利授权，专利号：ZL 201110141084.7.
