| 姓 名： | 夏晓勤 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | 86-27-68780915 |
| 电子邮件： | xqxia@ihb.ac.cn |
简历介绍：
1992年武汉大学生物系微生物学专业本科毕业，获理学学士学位；1997年中国科学院水生生物研究所水生生物学专业毕业，获理学博士学位；1997－2000年为南京农业大学动物医学院博士后、副教授；2000－2004年在剑桥大学通信系统研究中心和遗传学系任生物信息学研究助理；2004－2011年先后在美国加州西德尼基墨癌症中心和圣迭戈疫苗研究所担任基因组部门主任和生物信息部门主任；2010年起兼任加州大学尔湾分校二级项目科学家；2011年聘为中国科学院水生生物研究所研究员、博士生导师，建立水体生物信息学实验室，并作为发起人之一筹建了湖北省生物信息学会、任学会首届副理事长。
历年工作先后涉及鱼类病原学、细胞代谢网络仿真、基因芯片数据库与分析平台、肿瘤分子标记挖掘与预后建模、组学数据分析算法、基因组空间结构、冠状病毒宿主预测等方面。目前主要运用生物信息学与多组学技术开展鱼类遗传育种和鱼类肠肝免疫免疫工作，包括鱼类基因组的组装与功能注释、经济性状的分子解析、分子辅助育种与基因组选择育种技术、鱼类遗传育种的分子信息数据库与分析平台研发，已获得国家发明专利授权7项，发表SCI论文60余篇。
研究方向：
主要以经济鱼类为研究对象，以斑马鱼等模式鱼类和细胞培养为辅助，以细胞操作技术、基因组学等组学技术和生物信息学分析手段来开展如下研究：
（1）鱼类重要经济性状分子机制的解析及育种研究
① 解析养殖鱼类重要经济性状的分子机制
② 培育具有高产、优质等优良性状的鱼类新品种或新品系
（2）鱼类基因组育种的新技术与平台的研发
①开发大规模家系选育所需的相关技术，包括亲缘关系鉴定、基于AI技术的高通量表型测量、低成本的基因型鉴定与全基因组关联分析等
② 建立重要经济鱼类的基因组数据库系统及多组学数据分析平台
社会任职：
1. 农业生物信息湖北省重点实验室学术委员会副主任2. 中国生物信息学会（筹）农林信息学专委会委员
获奖及荣誉：
代表论著：
Zhang L, Fang Y, Shi M*, Ren K, Guan X, Younas W, Cheng Y, Zhang W, Wang Y, Xia X-Q*. Gonadal expression profiles reveal the underlying mechanisms of temperature effects on sex determination in the large-scale loach (Paramisgurnus dabryanus). Animal Reproduction Science, 2025, 272: 107661.
Liu Y, Su L, Cao D, Wu N*, Hu Y, Altaf F, Li J, Zhu Q, Liu J, Zhang Q, Liu H, Cheng Y, Zhang W, Unger BH, Chen W, Liu J, Wang Y, Xia X-Q*. Comparative analysis of seabuckthorn and its significant component in enhancing fish mucosal immunity. Aquculture, 2025, 596: 741752.
Li H, Zhang W, Ren K, Yang H, Zhang L, Younas W, Cheng Y, Wang Y, Shi M*, Xia X-Q*. FishCODE: a web-based information platform for comprehensive omics data exploration in fish research. Journal of Genetics and Genomics, 2024, 51: 1525-1528.
Cao D, Guo C, Shi M*, Liu Y, Fang Y, Yang H, Cheng Y, Zhang W, Wang Y, Li Y, Xia X-Q*. A method for custom measurement of fish dimensions using the improved YOLOv5-keypoint framework with multi-attention mechanisms. Water Biology and Security, 2024, 3: 100293.
任可意, 石米娟, 程莹寅, 张婉婷, 夏晓勤*. 斑马鱼模型在特发性脊柱侧凸研究中的应用. 医学综述. 2024, 30(14):1693-1699.
赵旭阳, 苏潋, 祝清松, 程莹寅, 吴南*, 夏晓勤*. 鱼类非感染性肠炎模型及其病理研究概述. 水产学杂志. 2024, 37(3): 109-116.
Zhang L#, Li H#, Shi M*, Ren K, Zhang W, Cheng Y, Wang Y, Xia X-Q*. FishSNP: a high quality cross-species SNP database of fishes. Scientific Data, 2024, 11:286.
Xia L#, Shi M#, Li H, Zhang W, Cheng Y, Xia X-Q*. PMSeeker: a scheme based on the greedy algorithm and the exhaustive algorithm to screen low-redundancy marker sets for large-scale parentage assignment with full parental genotyping. Biology, 2024, 13(2): 100.
Liu Y#, Cao D#, Wu N*, Zhao X, Zhu Q, Su L, Altaf F, Zhang Q, Liu H, Li Y, Unger BH, Cheng Y, Zhang W, Li A, Wang Y, Xia X-Q*. Sinomenine improves resistance to foodborne enteritis and anti-bacteria mucosal immunity in grass carp. Aquaculture, 2024, 581: 740364.
Zhao X#, Zhang L#, Wu N*, Liu Y, Xie J, Su L, Zhu Q, Unger BH, Altaf F, Hu Y, Ye W, Qiao Z, Cheng Y, Zhang W, Wang Y, Xia X-Q*. Gallic acid acts as an anti-inflammatory agent via PPARγ-mediated immunomodulation and antioxidation in fish gut-liver axis. Aquaculture, 2024, 578: 740142.
Guo C#, Ye W#, Cao D, Shi M*, Zhang W, Cheng Y, Wang Y, Xia X-Q*. Unraveling the stereoscopic gene transcriptional landscape of zebrafish using FishSED, a fish spatial expression database with multispecies scalability. Science China Life Sciences, 2024, 67(4): 843-846.
Ye W, Shi M*, Chen S, Duan Y, Jiang Y, Cheng Y, Zhang W, Chen J, Wang Y, Xia X-Q*. Transcriptome analysis revealed the existence of family-specific regulation of growth traits in grass carp. Genomics, 2023, 115(5): 110706.
Zhao X#, Liu Y#, Xie J, Guo C, Li H, Cheng Y, Zhang W, Su L, Wu N*, Xia X-Q*. The manipulation of cell suspensions from zebrafish intestinal mucosa contributes to understanding enteritis. Frontiers in Immunology, 2023, 14: 1193977.
Guo C#, Duan Y#, Ye W, Zhang W, Cheng Y, Shi M*, Xia X-Q*, FishGET: a fish gene expression and transcriptome database with improved accuracy and visualization. iScience, 2023, 26: 106539.
Guo C#, Ye W#, Shi M*, Duan Y, Zhang W, Cheng Y, Xia X-Q*. FishSCT: a zebrafish-centric database for exploration and visualization of fish single-cell transcriptome. Science China Life Sciences, 2023, 66(9): 2185-2188.
Ouyang G, Yuan L, Xia X-Q, Zhang W, Shi M*. Transcriptomes of zebrafish in early stages of multiple viral invasions reveal the role of sterols in innate immune switch-on. International Journal of Molecular Sciences, 2023, 24: 4427.
Ye W, Shi M*, Ren K, Liu Y, Duan Y, Cheng Y, Zhang W, Xia X-Q*. Profiling the spatial expression pattern and ceRNA network of lncRNA, miRNA, and mRNA associated with the development of intermuscular bones in zebrafish. Biology, 2023, 12(1): 75.
Li H, Shi M*, Ren K, Zhang L, Ye W, Zhang W, Cheng Y, Xia X-Q*. Visual Omics: a web-based platform for omics data analysis and visualization with rich graph-tuning capabilities. Bioinformatics, 2023, 39(1): btac777.
Shan J#, Wang G#, Li H, Zhao X, Ye W, Su L, Zhu Q, Liu Y, Cheng Y, Zhang W, Wu N*, Xia X-Q*. The immunoregulatory role of fish specific type II SOCS via inhibiting metaflammation in gut-liver axis. Water Biology and Security, 2023, 2(2): 100131.
Duan Y, Zhang Q, Jiang Y, Zhang W, Cheng Y, Shi M*, Xia X-Q*. Dynamic transcriptional landscape of grass carp (Ctenopharyngodon idella) reveals key transcriptional features involved in fish development. International Journal of Molecular Sciences, 2022, 23: 11547.
Li M#, Zhao X#, Xie J, Tong X, Shan J, Shi M, Wang G, Ye W, Liu Y, Unger BH, Cheng Y, Zhang W, Wu N*, Xia X-Q*. Dietary inclusion of seabuckthorn (Hippophae rhamnoides) mitigates foodborne enteritis in zebrafish through the gut-liver immune axis. Frontiers in Physiology, 2022, 13: 831226.
黎明, 谢家元, 赵旭阳, 李晓敏, 王锐, 单俊伟, 程莹寅, 张婉婷, 吴南*, 夏晓勤*. 斑马鱼食源性肠炎模型及其免疫细胞成像分析方法的建立. 水生生物学报, 2022, 46(2): 1-12.
石米娟, 张婉婷, 程莹寅, 夏晓勤*. 基于全基因组分析的鱼类育种技术原理与应用. 中国农业科技导报, 2022, 24(2): 33-41.
Xie J#, Li M#, Ye W, Shan J, Zhao X, Duan Y, Liu Y, Unger BH, Cheng Y, Zhang W, Wu N*, Xia X-Q*. Sinomenine hydrochloride ameliorates fish foodborne enteritis via α7nAchR mediated anti-inflammatory effect whilst altering microbiota composition. Frontiers in Immunology, 2021, 12: 766845.
