女，研究员，博士生导师。 

教育经历： 

1995.09-1999.07 华中农业大学水产学院，名特水产养殖专业，农学学士 

2000.09-2005.07 中国科学院水生生物研究所，水生生物学专业，理学博士 

工作经历： 

1999.07-2005.07 中国科学院水生生物研究所，研究实习员 

2005.07-2008.01 新加坡国立大学，博士后 

2008.09-2010.12 中国科学院水生生物研究所，助理研究员 

2010.12-2018.12 中国科学院水生生物研究所，副研究员 

2017.09-2018.09 帝国理工学院，访问学者 

2018.12-        中国科学院水生生物研究所，研究员 

主要研究鱼类细菌性病原爱德华氏菌及杀鲑气单胞菌的分泌系统及其致病机理，揭示病原毒力因子与宿主互作的免疫学机制。此外，研发鱼类细菌性病原的浸泡疫苗。 

科研项目： 

1.杀鱼爱德华氏菌EseJ蛋白调控I型菌毛和宿主细胞凋亡的研究，国家自然科学基金面上项目，2021.1-2024.12 

2.水产动物疫病发生的分子基础与免疫机制，国家重点研发计划“蓝色粮仓科技创新”专项子课题，2018.12-2022.12 

3.冷水鱼杀鲑气单胞菌病的发生及免疫防治机理研究，NSFC-山东联合基金重点支持项目，2018.1-2021.12  

4.杀鱼爱德华氏菌Ⅲ型分泌系统输送器蛋白的分子致病机理研究，国家自然科学基金面上项目，2016.1-2019.12 

5.鲶爱德华氏菌多拷贝质粒pEI1和pEI2编码的毒力蛋白的分子致病机理研究，国家自然科学基金面上项目，2012.1-2015.12 

6.鲶爱德华氏菌Ⅲ型与Ⅵ型分泌系统致病的分子机制研究，国家自然科学基金面上项目，2010.1-2012.12 

代表性科研论文： 

1.Wang Ping^#, Li Jie^#, He Tian Tian, Li Nan, Mo Zhao Lan, Nie Pin^*, Xie Hai Xia^*. Pathogenic characterization of Aeromonas salmonicida subsp.masoucida turbot isolate from China. Journal of Fish Diseases, 2020, 43:1145-1154.   

2.He Tian Tian, Zhou Ying, Liu Ying Li, Li Duan You, Nie Pin, Li Ai Hua^*, Xie Hai Xia^*. Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type I fimbriae, which stimulate the cleavage of caspase-8. Cellular Microbiology, 2020, 22:e13193. 

3.Zhang Qian^#, He Tian Tian^#, Li Duan You, Nie Pin^*, Xie Hai Xia^*. The Edwardsiella piscicida type III effector EseJ suppresses expression of type 1 fimbriae, leading to decreased bacterial adherence to host cells. Infection & Immunity, 2019, 87: e00187-19.  

4.Liu Ying Li, He Tian Tian, Liu Lu Yi, Yi Jia, Nie Pin, Yu Hong Bing, Xie Hai Xia^*. The Edwardsiella piscicida type III translocon protein EseC inhibits biofilm formation by sequestering EseE. Applied and Environmental Microbiology 2019, 85:e02133-18.  

5.Liu Lu Yi, Nie Pin^*, Yu Hong Bing, Xie Hai Xia^*. Regulation of type III secretion of translocon and effector proteins by the EsaB/EsaL/EsaM complex in Edwardsiella tarda. Infection & Immunity, 2017, 85:e00322-17. 

6.Yi Jia, Xiao Shui Bing, Zeng Zhi Xiong, Lu Jin Fang, Liu Lu Yi, Laghari Zubair Ahmed, Nie Pin, Yu Hong Bing, Xie Hai Xia^*. EseE of Edwardsiella tarda augments the secretion of translocon protein EseC and the expression of escC-eseE operon.  Infection & Immunity 2016, 84:2336-2344. 

7.Lu Jin Fang, Wang Wei Na, Wang Gai Ling, Zhang He, Zhou Ying, Gao Zhi Peng, Nie Pin^*, Xie Hai Xia^*. Edwardsiella tarda EscE (Orf13 protein) is a type III secretion system secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection & Immunity 2016, 84:2-10. 

8.Gao Zhi Peng, Nie Pin, Lu Jin Fang, Liu Lu Yi, Xiao Tiao Yi, Liu Wei, Liu Jia Shou^*, Xie Hai Xia^*. Type III secretion system translocon component EseB forms filaments and mediates autoaggregation and biofilm formation in Edwardsiella tarda. Applied and Environmental Microbiology 2015, 81:6078-6087. 

9.Xie Hai Xia^#, Lu Jin Fang^#, Zhou Ying, Yi Jia, Yu Xiu-Jun^*, Leung Ka Ying, Nie Pin^*. Identification and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection & Immunity 2015, 83:1650-1660. 

10.Xie Hai Xia, Lu Jin Fang, Rolhion Nathalie, Holden David W., Nie Pin^*, Zhou Ying, Yu Xiu-Jun^*. Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infection & Immunity 2014, 82:3436-3445.  

11.Zhao Li Juan, Lu Jin Fang, Nie Pin^*, Li Ai Hua, Xiong Bang Xi, Xie Hai Xia^*. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology 2013, 166:233-41. 

12.Xie Hai Xia, Yu Hong Bing, Zheng Jun, Foster Leonard J., Mok Yu-Keung, Finlay Brett B., Nie Pin, Leung Ka Yin^*. EseG, an effector of the type III secretion system of Edwardsiella tarda triggers microtubule destabilization. Infection & Immunity 2010, 78:5011-5021.