| 姓 名： | 刘兴 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | 86-27-68780962 |
| 电子邮件： | liuxing@ihb.ac.cn |
简历介绍：
于2003-2007年，在武汉大学生命科学学院获理学学士学位；2008-2013年，在中国科学院水生生物研究所获理学博士学位，并留所工作，任助理研究员；2017年晋升为副研究员。自工作以来，面向国家重大需求，致力于阐明鱼类耐低氧和抗病性状的分子遗传机制，为鱼类抗逆和抗病新品种的培育提供理论和技术支撑。迄今，已主持了国家自然科学基金青年项目、面上项目，湖北省自然科学基金青年项目、杰出青年基金项目，中国科学院B类先导专项项目，国家重点研发计划子课题等；入选了中国科学院青年创新促进会并获得专项人才资助。此外，作为科研骨干参与了国家自然科学基金重点项目、重点研发计划、以及中国科学院A类先导专项等项目的研究工作。已发表SCI论文50篇，其中第一或通讯作者论文21篇；以第一发明人获授权发明专利3项。鉴定到SET7、SIRT5、SMYD3、PHD3、SIRT7等多个与鱼类耐低氧和抗病性状相关的关键靶标基因。基于这些靶标基因，利用CRISPR/Cas9基因编辑技术，在草鱼、鲫、鲢和翘嘴鲌等多种养殖鱼类中，开展了抗逆、抗病新种质的创制，获得了多个耐低氧和抗病的经济鱼类新种质。获得了研究所2015年度青年科技奖、优秀论文奖；2020年度杰出创新奖和2021年度杰出创新奖；2020年度研究所首届“科研青年学者”荣誉称号，2022年入选中国科学院首批特聘研究骨干。
研究方向：
1)以斑马鱼作为模式生物，解析鱼类低氧耐受与低氧适应的遗传基础;
2)以斑马鱼作为模式生物，解析肿瘤发生和抗病毒天然免疫的分子机制;
3)解析低氧信号转导、细胞命运决定和抗病毒天然免疫应答的调控网络。
社会任职：
获奖及荣誉：
代表论著：
[1] Zeshan Lin#, Lei Chen#, Xianqing Chen#, Yingbin Zhong#, Yue Yang#, Wenhao Xia#, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu, Kjersti Sternang Kvie, Knut H？kon R？ed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas P. Gilbert, Qiang Qiu*, Wen Wang*, Zhipeng Li*. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364 eaav6312.
[2] Guangqing Yu#, Xing Liu#, Jinhua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432.
[3] Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259.
[4] Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380.
[5] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017, 45(22): 12700-12714..
[6] Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749.
[7] Xing Liu#, Xiaolian Cai#, Bo Hu#, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.
[8] Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945.
[9] Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.
[10] Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057.
[11] Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.
[12] Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.
[13] Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.
[14] Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.
[15] Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195.
[16] Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078.
[17] Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30: 3397-3415.
