| 姓 名： | 徐镇 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | |
| 电子邮件： | zhenxu@ihb.ac.cn |
简历介绍：
徐镇，研究员，博士生导师，鱼类黏膜免疫学科组组长，农业农村部淡水养殖病害防治重点实验室主任，中国水产学会鱼病专业委员会副主任委员。先后在山东农业大学（2002）、华中农业大学（2006、2009）获得农学学士、硕士和博士学位； 2010-2014年在美国宾夕法尼亚大学进行博士后研究； 2015-2020年，受聘于华中农业大学，任教授；2021年受聘于中国科学院水生生物研究所，任研究员。
主要从事鱼类黏膜免疫和病害防控的研究，阐明了鱼类黏膜抗感染的适应性免疫应答规律，揭示了鱼类维持黏膜免疫稳态的机制，在Science Immunology、Cell Discovery、Nature Communications、PNAS、Reviews in Aquaculture、PLOS Pathogens、iScience、Journal of Immunology等发表论文50余篇。获得国家基金委杰出青年基金、国家重点研发计划课题和中国科学院引才计划等项目支持。
研究方向：
鱼类黏膜免疫与病害防控
社会任职：
获奖及荣誉：
代表论著：
1. Yongyao Yu#, Zhenyu Huang#, Weiguang Kong#, Fen Dong#, Xiaoting Zhang, Xue Zhai, Gaofeng Cheng, Mengting Zhan, Jiafeng Cao, Liguo Ding, Guangkun Han, Fumio Takizawa, Yang Ding, J. Oriol Sunyer*, Zhen Xu*. (2022) Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses. Cell Discovery. 2022, 8:31.
2. Jiafeng Cao#, Liguo Ding#, Qingchao Wang#, Guangkun Han, Dacheng Qin, Gaofeng Cheng, Zhaoran Dong, Qingjiang Mu, Weiguang Kong, Xia Liu, Yongyao Yu, Zhen Xu*. (2022) Conserved role of mTORC1 signaling in B cell immunity in teleost fish. Journal of Immunology. 2022.
3. Xiaoting Zhang#, Yongyao Yu#, Haoyue Xu#, Zhenyu Huang, Xia Liu, Jiafeng Cao, Kaifeng Meng, Zhengben Wu, Guangkun Han, Mengting Zhan, Liguo Ding, Weiguang Kong, Nan Li, Fumio Takizawa, J. Oriol Sunyer, Zhen Xu*. (2021) Prevailing role of mucosal Igs and B cells in teleost skin immune responses to bacterial infection. Journal of Immunology. 2021, 206 (5): 1088-1101.
4. Yongyao Yu#, Liguo Ding#, Zhenyu Huang#, Haoyue Xu#, Zhen Xu*. (2021) Commensal bacteria-immunity crosstalk shapes mucosal homeostasis in teleost fish. Reviews in Aquaculture. 2021, 13: 2322-2343.
5. Zhen Xu#, Fumio Takizawa#, Elisa Casadei, Yasuhiro Shibasaki, Yang Ding, Thomas J. C. Sauters, Yongyao Yu, Irene Salinas*, J. Oriol Sunyer*. (2020) Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. Science Immunology. 2020, 5(44): eaay3254. (Cover Story)
6. Yongyao Yu#, Weiguang Kong#, Haoyue Xu, Zhenyu Huang, Xiaoting Zhang, Liguo Ding, Shuai Dong, Guangmei Yin, Fen Dong, Wei Yu, Jiafeng Cao, Kaifeng Meng, Xia Liu, Yu Fu, Xuezhen Zhang, Yongan Zhang, J. Oriol Sunyer, Zhen Xu*. (2019) Convergent evolution of mucosal immune responses at the buccal cavity of teleost fish. iScience. 2019, 19: 821-835.
7. Weiguang Kong#, Yongyao Yu#, Shuai Dong, Zhenyu Huang, Liguo Ding, Jiafeng Cao, Fen Dong, Xiaoting Zhang, Xia Liu, Haoyue Xu, Kaifeng Meng, Jianguo Su, Zhen Xu*. (2019) Pharyngeal immunity in early vertebrates provides functional and evolutionary insight into mucosal homeostasis. Journal of Immunology. 2019, 203(11): 3054-3067.
8. Yongyao Yu#, Weiguang Kong#, Yaxing Yin, Fen Dong, Zhenyu Huang, Guangmei Yin, Shuai Dong, Irene Salinas, Yongan Zhang, Zhen Xu*. (2018) Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection. PLOS Pathogens. 2018, 14(11): e1007251.
9. Zhen Xu, Fumio Takizawa, David Parra, Daniela Gomez, Louise von Gersdorff Jorgensen, Scott E. LaPatra, J. Oriol Sunyer*. (2016) Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Nature Communications. 2016, 7: 10728.
10. Zhen Xu#, David Parra#, Daniela Gomez#, Irene Salinas, Yongan Zhang, Louise von Gersdorff Jorgensen, Rasmus Demuth Heinecke, Kurt Buchmann, Scott LaPatra, J. Oriol Sunyer. (2013) Teleost skin, an ancient mucosal surface that elicits gut-like immune responses. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(32): 13097-13102.
