水产种质创新与未来渔业发展研究中心
姓 名: 殷战
性 别:
职 称: 研究员
电 话: 86-27-68780069
电子邮件: zyin@ihb.ac.cn

简历介绍:

个人简历:博士,研究员,博士生导师。

教育经历1986.7年毕业于武汉大学生物系;1989.7年在中国科学院水生生物所获得硕士学位;1999.7年在新加坡国立大学生物系获得博士学位。   

工作和培训经历1989.7-1994.8任水生所助理研究员; 1999.7-2003.5年在美国Case Western Reserve University医学院药学系做博士后研究;2003.5-2005.4在美国University of Pennsylvania医学院医学系分子心脏病学研究中心做博士后研究;2005年5月至今,中科院水生生物研究所研究员。  

2005年5月回到中国科学院水生生物研究所组建学科组以来,开展了鱼类内分泌对生长、肌肉发育等方面调控机制的研究工作。目前主要以斑马鱼为主要研究模式,并结合鲫鱼为养殖模式,集中关注鱼类的内分泌生长调控轴、在鱼类营养、代谢、生长、繁殖等方面的内分泌调控研究方面,开展了较为系统地研究工作。并在采用基因编辑技术和遗传标记辅助育种方面,针对模式鱼类和养殖鱼类的代谢调控、肌肉生长、可控性鱼类性腺发育技术研究等方面也正在取得许多深具潜力的研究进展。对利用斑马鱼为模式生物系统的环境内分泌干扰物评价体内模式也曾进行了一系列有益的探索。  

研究方向:

发育生物学,鱼类生长发育、代谢调控及繁殖过程的内分泌调控机制

社会任职:

获奖及荣誉:

2006年获中国科学院人才计划择优资助; 2009年获得国家杰出青年科学基金资助。2016年第二批国家级人才计划领军人才。

代表论著:

*通讯作者

1. Gang Zhai, Tingting Shu , Guangqing Yu , Haipei Tang , Chuang Shi  , Jingyi Jia  , Qiyong Lou, Xiangyan Dai , Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin* 2022Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling.  Elife . 2022 Feb 28;11:e66118. doi: 10.7554/eLife.66118.

2. Gang Zhai, Tingting Shu, Kuangxin Chen, Qiyong Lou, Jingyi Jia, Jianfei Huang, Chuang Shi, Xia Jin, Jiangyan He, Donghuo Jiang, Xueqiao Qian, Wei Hu and Zhan Yin* (2022) Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carps.  Engineering  Volume 8, January 2022, Pages 181-189 

3. Huang J, Shi C, Gao Y, Su J, Shu Y, Zeng N, Zhai G, Jin X, Han D, He J, Lou Q*, Yin Z*. 2021 Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio). Aquaculture. 545:737207. DOI: 10.1016/j.aquaculture.2021.737207. 

4. Shi, XT., Ye, C., Qin, XF., Zhou, LL., Xia, CH., Cai, TY., Xie, YY., Yin, Z.*, Hu, GF.* 2021. Novel pituitary actions of TAC4 gene products in teleost. International Journal of Molecular Science. In press 

5.  Xia, CH., Qin, XF., Zhou, LL., Shi, XT., Cai, XT., Xie, YY., Li, W., Du, RX., OuyangY., YingwenYin, Z.*, Hu, GF*. 2021. Reproductive regulation of PrRPs in teleost: the link between feeding and reproduction.Frontier in Endocrinology. In press.

6. Song, J., Lu, Y., Cheng, XX., Shi, C., Lou, QY., Jin, X., He, JY., Zhai, G*., Yin, Z*.2021. Functions of the Thyroid-Stimulating Hormone on key developmental features revealed in a series of zebrafish dyshormonogenesis models. Cells. 10(8); DOI10.3390/cells10081984.  

7. Xu, S., Zhou, L., Chen, X., Hu, Q., Shi, X., Xia, C., Zhang, H., Jia, J., Yin, Z.*, Hu, G*. 2021.  Novel pituitary actions of NKB for anorectic peptides regulation in grass carp. Aquaculture. 531: https://doi.org/10.1016/j.aquaculture.2020.735857 

8. Xiangyan Dai, Xinkai Cheng , Jianfei Huang , Yanping Gao , Deshou Wang, Zhi Feng , Gang Zhai , Qiyong LouJiangyan He , Zhijian Wang , Zhan Yin*2021Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis. Biol Reprod . 2021 May 7;104(5):1139-1153 doi: 10.1093/biolre/ioab016.  

9. Tingting Shu, Gang Zhaia, Ajay Pradhanc*, Per-Erik Olssonc, Zhan Yin*2020Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation  General and Comparative Endocrinology2020 Sep 1;295:113490.doi: 10.1016/j.ygcen.2020.113490. 

10. ?Jing Luo, Xiaokang Zhang, Siying He, Qiyong Lou, Gang Zhai, Chuang Shi, Zhan Yin , Fang  Zheng 2019Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish Redox Biology Volume 28, January 2020, 101355. 

11. Guohui Shang,  Xuyan Peng,  Cheng Ji,  Gang Zhai,  Yonglin Ruan,  Qiyong Lou,  Xia Jin,  Jiangyan He,  Han Wang,  Zhan Yin*2019Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish? Biology of Reproduction, Volume 101, Issue 4, October 2019, Pages 760–770, https://doi.org/10.1093/biolre/ioz132. 

12. Chuang Shi,  Yao Lu,  Gang Zhai,  Jianfei Huang,  Guohui Shang,  Qiyong Lou,  Dongliang Li,  Xia Jin,  Jiangyan He,  Zhenyu Du, Jianfang Gui,  Zhan Yin* 2019Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity Journal of Molecular Cell Biology, z053, htps://doi.org/10.1093/jmcb/mjz053. 

13. Zhai G, Shu T, Xia Y, Lu Y, Shang G, Jin X, He J, Nie P, Yin Z*. 2018 Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. Endocrinology 159(10):3549-62.  

14. Shu T, Shu Y, Gao Y, Jin X, He J, Zhai G#, Yin Z*. 2018. Depletion of tissue-specific ion transporters causes differential expression of PRL targets in response to increased levels of endogenous PRL. Frontiers in Endocrinology 9, 683. 

15. Gong Y, Zhai G, Su J, Yang B, Jin J, Liu H, Yin Z*, Xie S, Han D*. 2018. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. General and Comparative Endocrinology 269:33-45.  

16. Guibo Song, Mingjun Han, Zuhua Li, Xuedong Gan, Xiaowen Chen, Jie Yang, Sufang Dong, Ming Yan, Jun Wan, Yanggan Wang, Zhuliang Huang, Zhan Yin*, Fang  Zheng*  (2018).  Deletion of Pr72 causes cardiac developmental defects in Zebrafish  Plos one (https://doi.org/10.1371/journal.pone.0206883). 

17. Wang, J., Luo, J., Chen, Q., Wang, X., He, J., Zhang, W., Yin, Z., Zheng, F., Pan, H., Li, T., Lou, Q*., Wang, B*. (2018) Identification of LBX2 as a novel causal gene of atrial septal defect. International Journal of Cardiology. 265:188-194 

18. Yang B, Zhai G, Gong Y, Su J, Peng X, Shang G, Han D*, Jin J, Liu H, Du Z, Yin Z., Xie S. (2018). Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American Journal of Physiology - Endocrinology and metabolism 315, E38-E51. 

19. Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* . 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25 (OH) 2 D 3. Cell Reports. 19:1444-1455. 

20. Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z*. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics (In press) 

21. Dai, X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z. * 2017. Tdrd12 Is Essential for Germ Cell Development Maintenance in Zebrafish. International Journal of Molecular Sciences. 18(6), 1127;  

22. Yang, J., Li Z., Gan, X., Zhai, G., Gao, J., Xiong, C., Qiu, X., Wang, X., Yin, Z.*, Zheng, F.* 2016.  Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences. 17(11), 1746. 

23. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q and Yin Z* 2016. Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh.  Frontier in Endocrinology. 7:88. 

24. Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin Z. *2016. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A.  Science Bulletin. 62 (3), 197-203. 

25. Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W.*, Yin, Z*. 2016. The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models  Scientific Reports.6, Article number: 18597 

26. Dai X, Jin X, Chen X, He J, Yin Z*. 2015.  Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824.  

27. Dai X, Zhang W, Zhuo Z, He J, Yin Z*. 2015. Neuroendocrine regulation of somatic growth in fishes (Review).Science in China Life Science. 58(2):137-47. Review. 

28. Cheng,X., Chen,X., Li, D., Jin, X., He, J., Yin Z*. 2015. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. General and Comparative Endocrinology. 21487-94.

29. Cheng, X., Chen, X., Jin, X., He, J., Yin, Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278(1): 78-84.   

30. He, W., Dai, X., Chen, X., He, J., Yin, Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.   

31. Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)2199-2212.  

32. Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E.*, Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.   

33. Mei Y, Yin N, Jin X, He J, Yin Z* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9. 

34. Chen D, Li L, Tu X, Yin Z*, Wang Q*. 2013. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22(5):963-76.  

35. Cui X, Zhang, J., Du, R., Wang, L., Archacki, S., Zhang, Y., Yuan, M., Ke, T., Li, H., Li, D., Li, C., Li, DW., Tang, Z., Yin, Z*., Liu, M*. HSF4 is involved in DNA damage repair through regulation of Rad51.Biochimica et Biophysica Acta-Molecular Basis of Diseases. 1822(8):1308-15. 

36. Ji C., Jin X., He J.,Yin, Z*. 2012. Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2):149-155 

37. Jiang N., Jin X., He J., Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation. Biology of Reproduction. 87 (3) 54, 1-8. 

38. Chen X., Lou Q., He J. & Yin Z*. 2012. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development. PLoS ONE 6(12): e29515. 

39. Lou Q., He J., Hu L., Yin Z*. 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta - Molecular Cell Research. 823(5):1024-32. 

40. Li X., He J., Hu W & Yin Z * 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-74. 

41. Ma L., Li D., Wang J., He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.  

42. Trivedi CM*, Luo Y*, Yin Z*, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. 2007. HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3?. Nature Medicine. 13(3): 324-331. (*Equal first author).  

43. Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. 2006. Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology, Lung Cellular and Molecular Physiology. 291L191-199. (*Equal first author)

44. Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. 2003. C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. Journal of Biological Chemistry. 278, 22838-22845.  

45. Yin, Z. Haynie, J., Yang, X.,. Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. 2002. The essential role of Cited2, a negative regulator hif-1 in heart development and neurulation. Proceedings of National Academy of Sciences of the United States of America. 99, 10488-10493.  

出版专著:

1. 殷战,廖传松,刘家寿等,2021年,《丹江口水库增养殖容量与放养调控技术》,科学出版社。

2. 桂建芳,周莉,殷战,胡炜,童金苟,孙永华,肖武汉,2021年,《水产遗传育种学》,科学出版社

授权专利:

1. 殷战;梅芸;尹乃达;贺江燕。肾上腺素受体激动剂诱导胚胎型珠蛋白表达及其用途。专利号CN101926998B,授权公告日:201393日。

2. 殷战;石闯;童金苟;解绶启;娄气永;翟刚。一种促进鱼类生长性状改良的方法。专利号:CN201910413299.6,授权公告日:2019517日。

Last updated on April 8th, 2022

== 实验室与学会 ==
  • == 实验室与学会 ==
  • 淡水生态与生物技术国家重点实验室
  • 中国科学院藻类生物学重点实验室
  • 农业部淡水养殖病害防治重点实验室
  • 武汉白暨豚保护基金会
  • 湖北省海洋湖沼学会
  • 中国动物学会原生动物学分会
  • 中国动物学会斑马鱼分会
  • 湖北省暨武汉动物学会
  • 中国水产学会鱼病学专业委员会
  • 中国鱼类学会
== 平台建设 ==
  • == 平台建设 ==
  • “一带一路”海域赤潮数据库
  • 国家水生生物种质资源库
  • 国家斑马鱼资源中心
  • 中国科学院淡水藻种库
  • 中国科学院武汉生命科学大型仪器区域中心
  • 湿地生态系统观测研究野外站联盟
  • 中国科学院水生生物研究所分析测试中心
  • 中国科学院超级计算武汉分中心
  • 水生生物博物馆
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  • == 相关网站推荐 ==
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