| 姓 名： | 缪炜 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | 86-27-68780050 |
| 电子邮件： | miaowei@ihb.ac.cn |
简历介绍：
男，1974年5月生。中国科学院水生生物研究所研究员，博士生导师。1996年和1999年在武汉大学分获学士学位和硕士学位；2002年于中国科学院水生生物研究所获博士学位。2004年7月至2005年1月和2007年1月至2008年12月以高级访问学者身份分别在美国加洲大学圣巴巴拉分校和罗切斯特大学开展合作研究。
现任中国科学院水生生物研究所所长、中国科学院水生生物多样性与保护生物学重点实验室副主任。担任国际原生生物学家学会国际委员会委员、国际四膜虫研究指导委员会当然委员、中国动物学会理事、中国动物学会原生动物学分会副理事长兼秘书长。
在PloS Biology 、Genes & Devolpment和Nucleic Acids Research等国际重要学术期刊上发表了50余篇论文。主持建立了四膜虫功能基因组学数据库（Tetrahymena Functional Genomics Database, TetraFGD，http://tfgd.ihb.ac.cn/）和四膜虫比较基因组数据库（Tetrahymena comparative genomics database, TCGD， http://ciliate.ihb.ac.cn）。担任《Scientific Reports》和《Journal of Eukaryotic Microbiology》等学术期刊编委。主持国家自然基金重大研究计划集成项目和科技部国家国际科技合作专项等一批项目。 获“2010年武汉市学科带头人”、“2011年湖北省杰出青年科学基金”、“2015年国家杰出青年科学基金”、“2016年国务院政府特殊津贴专家”、“2017年武汉市优秀科技工作者”、 “2017年科技部中青年科技创新领军人才”。
研究方向：
1）原生动物生物系统学；2）原生动物进化与生态功能基因组学；3）原生动物基因工程技术。
社会任职：
获奖及荣誉：
代表论著：
1. Zhang J, Yan G, Tian M, Ma Y, Xiong J, Miao W*. A DP-like transcription factor protein interacts with E2fl1 to regulate meiosis in Tetrahymena thermophila. Cell Cycle. 2018 Mar 4;17(5):634-42. (5-Year IF: 3.799)
2.Tian M, Yang WT, Zhang J, Dang H, Lu XY, Fu CJ, Miao W*. 2017. Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nuclease. Nucleic Acids Research, 45:6848-6863. (5-Year IF: 10.235)
3.Feng LF, Wang GY, Hamilton EP, Xiong J, Yan GX, Chen K, Chen X, Dui W, Plemens A, Khadr L, Dhanekula A, Juma M, Dang HQ, Kapler GM, Orias E, Miao W*, Liu YF*. 2017. A germline-limited piggyBac transposase gene is required for precise excision in Tetrahymena genome rearrangement. Nucleic Acids Research, 45:9481-9502. (5-Year IF: 10.235)
4.Zhang J, Tian M, Yan GX, Shodhan A, Miao W*. E2fl1 is a meiosis-specific transcription factor in the protist Tetrahymena thermophila. Cell Cycle. 2017 Jan 2;16(1):123-35. (5-Year IF: 3.799)
5.Xiong J#, Gao S#, Dui W, Yang WT, Chen X, Taverna SD, Pearlman RE, Ashlock W, Miao W*, Liu YF*. 2016. Dissecting relative contributions of cis- and trans-determinants to nucleosome distribution by comparing Tetrahymena macronuclear and micronuclear chromatin. Nucleic Acids Research, 44:10091-10105. (5-Year IF: 10.235)
6.Yan GX, Zhang J, Shodhan A, Tian M, Miao W*. Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila. Cell Cycle. 2016 Sep 16;15(18):2506-14. (5-Year IF: 3.799)
7.Yan GX, Dang H, Tian M, Zhang J, Shodhan A, Ning YZ, Xiong J, Miao W*. Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila. Cell Cycle. 2016 Jul 17;15(14):1855-64. (5-Year IF: 3.799)
8.Feng JM, Jiang CQ, Warren A, Tian M, Cheng J, Liu GL, Xiong J, Miao W*. 2015. Phylogenomic analyses reveal subclass Scuticociliatia as the sister group of subclass Hymenostomatia within class Oligohymenophorea. Molecular Phylogenetics and Evolution, 90:104-111. (5-Year IF: 4.294)
9. Xiong J, Wang G, Cheng J, Tian M, Pan X, Warren A, Jiang C, Yuan D, Miao W*. Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer. Scientific Reports. 2015 Oct 21;5:15470. (5-Year IF: 4.609)
10. Tian M, Chen XL, Xiong Q, Xiong J, Xiao CL, Ge F*, Yang FQ*, Miao W*. 2014. Phosphoproteomic Analysis of Protein Phosphorylation Networks in Tetrahymena thermophila, a Model Single-celled Organism. Molecular & Cellular Proteomics, 13:503-519. (5-Year IF: 6.323)
11. Feng L, Fu C, Yuan D, Miao W*. A P450 gene associated with robust resistance to DDT in ciliated protozoan, Tetrahymena thermophila by efficient degradation. Aquatic Toxicology. 2014 Apr 1;149:126-32. (5-Year IF: 4.143)
12. Ye J, Chang Y, Yan Y, Xiong J, Xue XM, Yuan D, Sun GX, Zhu YG*, Miao W*. Identification and characterization of the arsenite methyltransferase from a protozoan, Tetrahymena pyriformis. Aquatic Toxicology. 2014 Apr 1;149:50-7. (5-Year IF: 4.143)
13. Chang Y, Liu G, Guo L, Liu H, Yuan D, Xiong J, Ning Y, Fu C, Miao W*. Cd‐Metallothioneins in Three Additional Tetrahymena Species: Intragenic Repeat Patterns and Induction by Metal Ions. Journal of Eukaryotic Microbiology. 2014 Jul;61(4):333-42. (5-Year IF: 2.761)
14. Xiong J, Lu YM, Feng JM, Yuan DX, Tian M, Chang Y, Fu CJ, Wang GY, Zeng HH*, Miao W*. 2013. Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics. Database-OXFORD, bat008. (5-Year IF: 3.755)
15. Gao S, Xiong J, Zhang CC, Berquist BR, Yang RD, Zhao M, Molascon AJ, Kwiatkowski SY, Yuan DX, Qin ZH, Wen JF, Kapler GM, Andrews PC, Miao W*, Liu YF*. 2013. Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes & Development, 27:1662-1679. (5-Year IF: 10.567)
16. Cervantes MD, Hamilton EP, Xiong J, Lawson MJ, Yuan DX, Hadjithomas M, Miao W*, Orias E*. 2013. Selecting One of Several Mating Types through Gene Segment Joining and Deletion in Tetrahymena thermophila. Plos Biology, 11(3): e1001518. (5-Year IF: 9.527)
17. Xiong J, Lu X, Zhou Z, Chang Y, Yuan D, Tian M, Zhou Z, Wang L, Fu C, Orias E, Miao W*. Transcriptome analysis of the model protozoan, Tetrahymena thermophila, using deep RNA sequencing. PloS ONE. 2012 Feb 7;7(2):e30630. (5-Year IF: 3.352)
18. Xiong J, Feng L, Yuan D, Fu C, Miao W*. Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family. BMC Evolutionary Biology. 2010 Dec;10(1):330. (5-Year IF: 3.628)
19. Miao W*, Xiong J, Bowen J, Wang W, Liu YF, Braguinets O, Grigull J, Pearlman RE, Orias E, Gorovsky MA*. 2009. Microarray Analyses of Gene Expression during the Tetrahymena thermophila Life Cycle. Plos ONE, 4(2): e4429. (5-Year IF: 3.352)
20. Fu C, Xiong J, Miao W*. 2009. Genome-Wide Identification and Characterization of Cytochrome P450 Monooxygenase Genes in the Ciliate Tetrahymena Thermophila [J]. BMC Genomics, 10: 208. (5-Year IF: 4.257)
21. Feng L, Miao W*, Wu Y. Differentially expressed genes of Tetrahymena thermophila in response to tributyltin (TBT) identified by suppression subtractive hybridization and real time quantitative PCR. Aquatic Toxicology. 2007 Feb 15;81(1):99-105. (5-Year IF: 4.143)
22. Miao W*, Yu T, Orias E, Wan ML, Fu CJ. 2006. Identification of differentially expressed genes in Tetrahmena thermophila in response to dichlorodiphenyltrichloroethane (DDT) by suppression subtractive hybridization. Environmental Microbiology, 8:1122-1129. (5-Year IF: 5.462)
