杨丽华，女，博士，研究员。2006年毕业于四川大学环境科学专业，获学士学位；2011年毕业于中国科学院生态环境研究中心环境科学专业，获理学博士学位；同年进入中国科学院水生生物研究所工作，研究方向为环境毒理学。本人长期从事水体中污染物的环境监测、毒性效应评价和风险评价工作，先后主持国家自然科学基金面上/青年项目、重点研发专项子课题/子任务、中国工程院新冠应急委托任务等，并以骨干身份参与国自然重点项目/中国科学院先导专项/“十三五”水专项等多个项目/课题。共发表学术论文80余篇，其中以第一或通讯作者在Environmental Health Perspectives、Environmental science & technology和Environment International等权威期刊发表论文40余篇，参与编写专著1部，授权软著及发明专利各1项。2024年入选湖北省“青年拔尖”人才计划，目前担任《生态毒理学报》、《Ecotoxicology and Environmental Safety》等期刊编委和《Hygiene and Environmental Health Advances》期刊青年编委。

1.新污染物的毒性效应及分子机制

2.新污染物的暴露水平、生态及健康风险评价

1. Yang Lihua#, Zhang Yindan#, Hua Jianghuan*, Song Guili, Li Fan, Zheng Na, Zhang Taotao, Xu Zhixiang, Ren Xinxin, Zhu Biran, Han Yanna, Guo Yongyong, Han Jian, Zhou Bingsheng*, Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro, ENVIRONMENTAL HEALTH PERSPECTIVES, 2024,132(11),117005.

2. Sun, Yumiao; Zhou, Shanqi; Zhu, Biran; Li, Fan; Fu, Kaiyu; Guo, Yongyong; Men, Jun; Han, Jian; Zhang, Wei; Yang, Lihua*; Zhou, Bingsheng, Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023, 57, 2887-2897.

3. Yang, Lihua; Zhu, Biran; Zhou, Shanqi; Zhao, Min; Li, Ruiwen; Zhou, Yuxi; Shi, Xiongjie; Han, Jian; Zhang, Wei; Zhou, Bingsheng, Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023,57,11043-11055

4. Fu, Kaiyu; Zhu, Biran; Sun, Yumiao; Zhou, Yuxi; Pang, Hao; Ren, Xinxin; Guo, Yongyong; Shi, Xiongjie; Han, Jian; Yang, Lihua*; Zhou, Bingsheng, Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024,58,4937-4947

5. Fan Li, Guili Song, Xiaochen Wang, Yumiao Sun, Shanqi Zhou, Yindan Zhang, Jianghuan Hua, Biran Zhu, Lihua Yang*, Wei Zhang, and Bingsheng Zhou, Evidence for Adverse Effects on Liver Development and Regeneration in Zebrafish by Decabromodiphenyl Ethane, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023,57,19419-19429

6. Zheng, Na; Wang, Xiaochen; Zhang, Yindan; Hua, Jianghuan; Zhu, Biran; Zhou, Yuxi; Xu, Zhixiang; Luo, Lijun; Han, Jian; Yang, Lihua*; Zhou, Bingsheng, Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy) ethane-Induced Male Reproductive Toxicity in Zebrafish, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024,58,8251-8263

7. Sun, Yumiao; Wang, Xiaochen; Zhou, Shanqi; Zhou, Yuxi; Hua, Jianghuan; Guo, Yongyong; Wang, Yan; Zhang, Wei; Yang, Lihua*; Zhou, Bingsheng*, Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE), ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023, 57,16811-16822

8. Fu, Kaiyu; Hua, Jianghuan; Zhang, Yindan; Du, Mingpu; Han, Jian; Li, Na; Wang, Qiangwei; Yang, Lihua*; Li, Ruiwen*; Zhou, Bingsheng, Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2023,58,194-206

9. Yuxi Zhou, Fan Li, Kaiyu Fu, Yindan Zhang, Na Zheng, Huijia Tang, Zhixiang Xu, Lijun Luo, Jian Han, Lihua Yang* and Bingsheng Zhou*, Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1- Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2024, 58,4581-4593

10. Sun, Yumiao; Zhu, Biran; Ling, Siyuan; Yan, Biao; Wang, Xiulin; Jia, Shuzhao; Martyniuk, Christopher J.; Zhang, Wei; Yang, Lihua*; Zhou, Bingsheng*, Decabromodiphenyl Ethane Mainly Affected the Muscle Contraction and Reproductive Endocrine System in Female Adult Zebrafish, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022,56,470-479

11. Zhu, Biran; Lei, Lei; Sun, Yumiao; Shi, Xiongjie; Fu, Kaiyu; Hua, Jianghuan; Martyniuk, Christopher J.; Han, Jian*; Yang, Lihua*; Zhou, Bingsheng, Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 56, 11516-11526.

12. Liu, Sitian; Song, Guili; Li, Fan; Li, Ruiwen; Chen, Xiangping; Guo, Yongyong; Zhou, Fang; Wang, Qiangwei; Yang, Lihua; Zhou, Bingsheng, Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies, JOURNAL OF HAZARDOUS MATERIALS,2021,424,127386

13. Zhu, Biran; Chen, Xianglin; Zhang, Taotao; Zhang, Qianqian; Fu, Kaiyu; Hua, Jianghuan; Zhang, Mengyuan; Qi, Qing; Zhao, Binbin; Zhao, Min*; Yang, Lihua*; Zhou, Bingsheng, Interactions between intestinal microbiota and metabolites in zebrafish larvae exposed to polystyrene nanoplastics: Implications for intestinal health and glycolipid metabolism, JOURNAL OF HAZARDOUS MATERIALS, 2024,472, 134478.

14. Hu, Zhichao#; Yang, Lihua#; Han, Jian; Liu, Zishu; Zhao, Yuxiang; Jin, Yihao; Sheng, Yaqi; Zhu, Lizhong; Hu, Baolan, Human viruses lurking in the environment activated by excessive use of COVID-19 prevention supplies, ENVIRONMENT INTERNATIONAL, 2022,163, 107192

15. Yang, Lihua; Zha, Jinmiao; Guo, Yongyong; Zhou, Bingsheng, Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays, SCIENCE OF THE TOTAL ENVIRONMENT, 2020,716,136987

16. Sun, Yumiao; Wang, Xiaochen; Guo, Wei; Li, Fan; Hua, Jianghuan; Zhu, Biran; Guo, Yongyong; Han, Jian; Yang, Lihua*; Zhou, Bingsheng, Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish, SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 950,175337

17. Chen, Xiangping; Lei, Lei; Liu, Sitian; Han, Jian; Li, Ruiwen; Men, Jun; Li, Lin; Wei, Lin; Sheng, Yaqi; Yang, Lihua*; Zhou, Bingsheng; Zhu, Lizhong, Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China, SCIENCE OF THE TOTAL ENVIRONMENT, 2021,792, 148352

18. Yang, Lihua; Huang, Tao; Li, Ruiwen; Souders, Christopher L.; Rheingold, Spencer; Tischuk, Claire; Li, Na; Zhou, Bingsheng; Martyniuk, Christopher J., Evaluation and comparison of the mitochondrial and developmental toxicity of three strobilurins in zebrafish embryo/larvae, ENVIRONMENTAL POLLUTION, 2021,270,116277

19. Peng, Wei; Liu, Sitian; Guo, Yongyong; Yang, Lihua*; Zhou, Bingsheng, Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae, ENVIRONMENTAL POLLUTION, 2020,259,113923

20. Li, Ruiwen; Yang, Lihua*; Han, Jian; Zou, Yu; Wang, Yingcai; Feng, Chenglian; Zhou, Bingsheng, Early-life exposure to tris (1,3-dichloro-2-propyl) phosphate caused multigenerational neurodevelopmental toxicity in zebrafish via altering maternal thyroid hormones transfer and epigenetic modifications, ENVIRONMENTAL POLLUTION, 2021,285,117471