| 姓 名： | 陈联国 |
|---|---|
| 性 别： | 男 |
| 职 称： | 研究员 |
| 电 话： | |
| 电子邮件： | lchenam#ihb.ac.cn |
简历介绍：
研究员，博士生导师，环境污染与生态风险研究组组长。
2008年，获中国海洋大学水产养殖专业学士学位；
2012年，获中国科学院水生生物研究所环境毒理专业硕士学位；
2016年，获香港科技大学海洋环境科学专业哲学博士学位；
2016年9月至2018年8月，在香港城市大学海洋污染国家重点实验室从事博士后阶段研究；
2018年9月，通过中国科学院人才计划引进水生所工作。
主要研究方向为水生态毒理学，阐明典型或新型持久性有机污染物的环境行为、毒性效应、作用机理及控制技术。以第一作者或通讯作者在环境科学或毒理学领域的国际主流刊物发表SCI论文47篇（影响因子>3），其中Environmental Science & Technology发表10篇（影响因子：7.864），Environmental Science & Technology Letters发表1篇（影响因子：7.678）。研究成果受到美国 “Environmental Health News”、新华社、中科院之声等科学媒体的关注和报导，并被挪威环保局采用、作为污染物风险评估的主要依据。现主持国家自然科学基金面上项目、青年基金、香港国际合作项目、中科院知识创新工程青年人才专项等研究任务。
研究方向：
（1）揭示污染物对内分泌系统、繁殖功能、神经系统、微生物群落、及营养代谢等方面的毒性效应；
（2）开发新型毒理学研究技术，确定污染物的结合靶点和分子起始事件，构建有害结局通路；
（3）基于益生菌与益生元，开发污染物毒性危害控制措施。
社会任职：
中国毒理学会分析毒理专业委员会青年委员；
Toxics期刊Guest Editor；
国家自然科学基金函评专家
获奖及荣誉：
2020年，国家青年海外人才计划（中组部）
2020年，武汉市黄鹤英才
2020年，武汉市青年科技朝阳计划
2019年，湖北省海外人才引进计划
2019年，湖北省青年科技晨光计划
2019年，教育部自然科学二等奖
2018年，中科院海外人才引进计划（择优支持）
2013年，香港科技大学理学院Research Excellence Award
代表论著：
#共同第一作者；*通讯作者
Environmental Science & Technology (IF: 7.864):
1. Hu, C., Liu, M., Wan, T., Tang, L., Sun, B., Zhou, B., Lam, J.C.W., Lam, P.K.S., Chen, L.* Disturbances in microbial and metabolic communication across the gut-liver axis induced by a dioxin-like pollutant: An integrated metagenomics and metabolomics analysis. Environmental Science & Technology 2020, 55, 529？537.
2. Chen, L.,* Lam, J.C.W., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B.* Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental Science & Technology 2020, 54, 7494？7503.
3. Chen, L.,* Tsui, M.M.P., Hu, C., Wan, T., Au, D.W.T., Lam, J.C.W., Lam, P.K.S., Zhou, B. Parental exposure to perfluorobutanesulfonate impairs offspring development through inheritance of paternal methylome. Environmental Science & Technology 2019, 53, 12018？12025.
4. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Lam, P.K.S., Zhou, B. Perfluorobutanesulfonate exposure skews sex ratio in fish and transgenerationally impairs reproduction. Environmental Science & Technology 2019, 53, 8389？8397.
5. Chen, L., Hu, C., Tsui, M.M.P., Wan, T., Peterson, D.R., Shi, Q., Lam, P.K.S., Au, D.W.T., Lam, J.C.W.,* Zhou, B.* Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology 2018, 52, 4432–4439.
6. Chen, L., Zhang, W.,# Hua, J., Hu, C., Lai, N.L.S., Qian, P.Y., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysregulation of intestinal health by environmental pollutants: Involvement of the estrogen receptor and aryl hydrocarbon receptor. Environmental Science & Technology 2018, 52, 2323–2330.
7. Chen, L., Au, D.W.T., Hu, C., Peterson, D.R., Zhou, B.,* Qian, P.Y.* Identification of molecular targets for 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in teleosts: New insight into mechanism of toxicity. Environmental Science & Technology 2017, 51, 1840–1847.
8. Chen, L., Zhang, W., Ye, R., Hu, C., Wang, Q., Seemann, F., Au, D.W.T., Zhou, B., Giesy, J.P., Qian, P.Y.* Chronic exposure of marine medaka (Oryzias melastigma) to 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) reveals its mechanism of action in endocrine disruption via the hypothalamus-pituitary-gonadal-liver (HPGL) axis. Environmental Science & Technology 2016, 50, 4492–4501.
9. Chen, L., Sun, J.,# Zhang, H., Au, D.W.T., Lam, P.K.S., Zhang, W., Bajic, V.B., Qiu, J.W., Qian, P.Y.* Hepatic proteomic responses in marine medaka (Oryzias melastigma) chronically exposed to antifouling compound butenolide [5-octylfuran-2(5H)-one] or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Environmental Science & Technology 2015, 49, 1851–1859.
10. Chen, L., Yu, K.,# Huang, C., Yu, L., Zhu, B., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 2012, 46, 9727–9734.
Environmental Science & Technology Letters (IF: 7.678):
11. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Wang, Q., Giesy, J.P., Lam, P.K.S. Perfluorobutanesulfonate exposure causes durable and transgenerational dysbiosis of gut microbiota in marine medaka. Environmental Science & Technology Letters 2018, 5, 731–738.
Environmental Pollution (IF: 6.792):
12. Tang, L., Liu, M., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos. Environmental Pollution 2020, 266, 115284.
13. Liu, M., Song, S., Hu, C., Tang, L., Lam, J.C.W., Lam, P.K.S., Chen, L.* Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish. Environmental Pollution 2020, 265, 114832.
14. Sun, Y.,# Tang, L.,# Liu, Y., Hu, C., Zhou, B., Lam, P.K.S., Lam, J.C.W., Chen, L.* Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish. Environmental Pollution 2019, 255, 113357.
15. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Wang, Q., Hu, C., Wai, O.W.H., Zhou, B., Lam, P.K.S. Contamination by perfluoroalkyl substances and microbial community structure in Pearl River Delta sediments. Environmental Pollution 2019, 245, 218–225.
16. Chen, L., Hu, C., Lai, N.L.S., Zhang, W., Hua, J., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 2018, 240, 17–26.
17. Chen, L., Guo, Y., Hu, C., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution 2018, 234, 307–317.
18. Chen, L., Wang, X., Zhang, X., Lam, P.K.S., Guo, Y., Lam, J.C.W.,* Zhou, B.* Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 2017, 230, 96–106.
19. Chen, L., Zhu, B., Guo, Y., Xu, T., Lee, J.-S., Qian, P.Y., Zhou, B.* High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae. Environmental Pollution 2016, 214, 324–333.
Science of the Total Environment (IF: 6.551):
20. Hu, C., Liu, M.,# Tang, L., Sun, B., Huang, Z., Chen, L.* Probiotic Lactobacillus rhamnosus modulates the impacts of perfluorobutanesulfonate on oocyte developmental rhythm of zebrafish. Science of the Total Environment 2021, 776, 145975.
21. Guo, Y., Chen, L.,# Wu, J., Hua, J., Yang, L., Wang, Q., Zhang, W., Lee, J.S., Zhou, B.* Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring. Science of the Total Environment 2019, 650, 557–565.
22. Chen, L.,* Tsui, M.M.P., Lam, J.C.W., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S. Variation in microbial community structure in surface seawater from Pearl River Delta: Discerning the influencing factors. Science of the Total Environment 2019, 660, 136–144.
Chemosphere (IF: 5.778):
23. Hu, C., Tang, L., Liu, M., Lam, P.K.S., Lam, J.C.W.,* Chen, L.* Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology. Chemosphere 2020, 258, 127409.
24. Tang, L., Song, S., Hu, C., Liu, M., Lam, P.K.S., Zhou, B., Lam, J.C.W., Chen, L.* Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish. Chemosphere 2020, 256, 127169.
25. Zhu, B.,* He, W., Yang, F., Chen, L.* High-throughput transcriptome sequencing reveals the developmental toxicity mechanisms of niclosamide in zebrafish embryo. Chemosphere 2020, 244, 125468.
26. Chen, L.,* Hu, C., Guo, Y., Shi, Q., Zhou, B. TiO2 nanoparticles and BPA are combined to impair the development of offspring zebrafish after parental coexposure. Chemosphere 2019, 217, 732–741.
27. Chen, L., Xu, Y., Wang, W., Qian, P.Y.* Degradation kinetics of a potent antifouling agent, butenolide, under various environmental conditions. Chemosphere 2015, 119, 1075–1083.
Ecotoxicology and Environmental Safety (IF: 4.872):
28. Liu, M., Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Interaction between probiotic additive and perfluorobutanesulfonate pollutant on offspring growth and health after parental exposure using zebrafish. Ecotoxicology and Environmental Safety 2021, 214, 112107.
29. Shi, Q., Tsui, M.M.P., Hu, C., Lam, J.C.W., Zhou, B., Chen, L.* Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae. Ecotoxicology and Environmental Safety 2019, 179, 119–126.
30. Tsui, M.M.P., Chen, L.,# He, T., Wang, Q., Hu, C., Lam, J.C.W., Lam, P.K.S.* Organic ultraviolet (UV) filters in the South China sea coastal region: Environmental occurrence, toxicological effects and risk assessment. Ecotoxicology and Environmental Safety 2019, 181, 26–33.
Aquatic Toxicology (IF: 4.344):
31. Chen, L.* Visual system: an understudied target of aquatic toxicology. Aquatic Toxicology 2020, 225, 105542.
32. Tang, L., Liu, M., Song, S., Hu, C., Lam, P.K.S., Lam, J.C.W., Chen, L.* Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos. Aquatic Toxicology 2020, 222, 105466.
33. Chen, L., Tsui, M.M.P., Shi, Q., Hu, C., Wang, Q., Zhou, B., Lam, P.K.S.,* Lam, J.C.W.* Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure. Aquatic Toxicology 2018, 201, 1–10.
34. Chen, L., Au, D.W.T., Hu, C., Zhang, W., Zhou, B., Cai, L., Giesy, J.P., Qian, P.Y.* Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3′-diindolylmethane (DIM). Aquatic Toxicology 2017, 183, 135–143.
35. Chen, L., Ye, R., Xu, Y., Gao, Z., Au, D.W.T., Qian, P.Y.* Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquatic Toxicology 2014, 149, 116–125.
36. Chen, L., Zhang, H.,# Sun, J., Wong, Y.H., Han, Z., Au, D.W.T., Bajic, V.B., Qian, P.Y.* Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Aquatic Toxicology 2014, 157, 47–56.
37. Chen, L., Hu, C., Huang, C., Wang, Q., Wang, X., Yang, L., Zhou, B.* Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 2012, 120–121, 11–18.
Journal of Environmental Sciences (IF: 4.302):
38. Liu, M., Sun, Y.,# Tang, L., Hu, C., Sun, B., Huang, Z., Chen, L.* Fingerprinting fecal DNA and mRNA as a non-invasive strategy to assess the impact of polychlorinated biphenyl 126 exposure on zebrafish. Journal of Environmental Sciences 2021, 106, 15–25.
39. Chen, L.,* Lam, J.C.W. SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern. Journal of Environmental Sciences 2017, 61, 68–79.
Chemical Research in Toxicology (IF: 3.184):
40. Tang, L., Song, S., Hu, C., Lam, J.C.W., Liu, M., Zhou, B., Lam, P.K.S., Chen, L.* Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish. Chemical Research in Toxicology 2020, 33, 1605–1608.
41. Chen, L., Ye, R., Zhang, W., Hu, C., Zhou, B., Peterson, D.R., Au, D.W.T., Lam, P.K.S., Qian, P.Y.* Endocrine disruption throughout the hypothalamus-pituitary-gonadal-liver (HPGL) axis in marine medaka (Oryzias melastigma) chronically exposed to the antifouling and chemopreventive agent, 3,3'-diindolylmethane (DIM). Chemical Research in Toxicology 2016, 29, 1020–1028.
Marine Pollution Bulletin (IF: 4.049):
42. Chen, L., Lam, J.C.W., Zhang, X., Pan, K., Guo, C., Lam, P.K.S, Wang, W., Liu, H., Qian, P.Y.* Relationship between metal and polybrominated diphenyl ether (PBDE) body burden and health risks in the barnacle Balanus amphitrite. Marine Pollution Bulletin 2015, 100, 383–392.
Environmental Toxicology and Chemistry (IF: 3.152):
43. Chen, L., Huang, C., Hu, C., Yu, K., Yang, L., Zhou, B.* Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental Toxicology and Chemistry 2012, 31, 2338–2344.
44. Chen, L., Huang, Y., Huang, C., Hu, B., Hu, C., Zhou, B.* Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environmental Toxicology and Chemistry 2013, 32, 1370–1375.
Progress in Organic Coatings (IF: 4.469):
45. Chen, L., Xia, C., Qian, P.Y.* Optimization of antifouling coatings incorporating butenolide, a potent antifouling agent via field and laboratory tests. Progress in Organic Coatings 2017, 109, 22–29.
Marine Drugs (IF: 4.073):
46. Chen, L., Qian, P.Y.* Review on molecular mechanisms of antifouling compounds: An update since 2012. Marine Drugs 2017, 15, 264.
Environmental Toxicology and Pharmacology (IF: 3.292):
47. Xu, T., Chen, L.,* Hu, C., Zhou, B. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environmental Toxicology and Pharmacology 2013, 35, 13–20.
