论文标题: |
Processing of PatS, a morphogen precursor, in cell extracts of Anabaena sp PCC 7120 |
作者: |
Zhang, Lianglin; Zhou, Fang; Wang, Shuai; Xu, Xudong |
出版刊物: |
FEBS LETTERS |
出版日期: |
MAR |
出版年份: |
2017 |
卷/期: |
5 |
DOI: |
10.1002/1873-3468.12582 |
论文摘要: |
Upon N-stepdown, Anabaena sp. PCC 7120 differentiates heterocysts along filaments in a semiregular pattern. A 17-amino acid peptide called PatS is a morphogen precursor for pattern formation. The principal PatS derivative involved in heterocyst patterning has been proposed to be the C-terminal peptide PatS-5 (RGSGR), PatS-6 (ERGSGR), or PatS-8 (CDERGSGR). We present the first evidence for processing of PatS in cell extracts of this cyanobacterium. PatS is probably cleaved between the C-terminal 7th and 8th amino acid residues, producing PatS-7 (DERGSGR), then converted into PatS-6 and PatS-5. The processing site could be changed by a substitution at the C-terminal 8th residue. |