| 论文标题： |
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans |
| 作者： |
Jiang, Wei; Wei, Yuehua; Long, Yong; Owen, Arthur; Wang, Bingying; Wu, Xuebing; Luo, Shuo; Dang, Yongjun; Ma, Dengke K. |
| 出版刊物： |
ELIFE |
| 出版日期： |
APR 17 |
| 出版年份： |
2018 |
| 卷/期： |
|
| DOI： |
10.7554/eLife.35037 |
| 论文摘要： |
How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60, zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolonged zip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, of C. elegans. zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions. |
