| 论文标题： |
Bichirs employ similar genetic pathways for limb regeneration as are used in lungfish and salamanders |
| 作者： |
Lu, Suxiang; Yang, Liandong; Jiang, Haifeng; Chen, Juan; Yu, Guangqing; Chen, Zhiguo; Xia, Xichao; He, Shunping |
| 出版刊物： |
GENE |
| 出版日期： |
MAR 30 |
| 出版年份： |
2019 |
| 卷/期： |
|
| DOI： |
10.1016/j.gene.2018.12.031 |
| 论文摘要： |
Bichirs are a sister group to sarcopterygian and tetrapods that can fully regenerate their endochondral-skeleton-fins. Histological and transcriptomic comparison approaches have been used to investigate the morphology and genetic basis of bichir lobe-fin regeneration, with strong down-regulation of muscle-related genes and up-regulation of ECM-related genes and developmental genes being observed. Bichir limb regeneration involves similar cellular processes to those employed by lungfish and salamander, with MARCKS-like protein (MLP) that is known to be a putative regeneration-initiating molecule in salamander, also up-regulated in the early stages of bichir lobe-fin regeneration. These gene expression results suggest that limb regeneration pathways in these amphibians have a common ancestral inheritance, consistent with evolution from endochondral-skeleton-fin structures to endochondral-skeleton-limb structures of vertebrates. |
