论文
论文标题: In vivo pharmacological investigation of Monotheca buxifolia and Bosea amherstiana using animal models
作者: Hassan, Said; Ahmad, Bashir; Khan, Shahid Ullah; Huang Linfang; Anjum, Syed Ishtiaq; Ansari, Muhammad Javed; Rahman, Khaista; Ahmad, Iftikhar; Khan, Wasim Ullah; Qamar, Rabia; Man, Shad; Nabi, Ghulam; Shah, Ayesha Haleem
出版刊物: SAUDI JOURNAL OF BIOLOGICAL SCIENCES
出版日期: NOV
出版年份: 2019
卷/期: 7
DOI: 10.1016/j.sjbs.2018.10.008
论文摘要: Experimental based evidence suggests that most of the medicinal plants possess wide-ranging pharmacological and biological activities that may possibly use in treatment of inflammation-related diseases. The current study was aimed to explore the acute toxicity, analgesic, sedative and antipyretic activities of Monotheca buxifolia and Bosea amherstiana in mices. In vivo experimental models were used in this study. Acute toxicity was evaluated for 24 h' interval at concentration of 500, 1000, 1500 and 2000 mg/kg. The analgesic activity was estimated by acetic acid induced writhing test. White wood apparatus enclosed in stainless steel was used for sedative experiment and antipyretic activity was evaluated in brewer's yeast induced hyperthermic at 50, 100 and 150 mg/kg i.p. Both plants were found safe at all tested doses. Monotheca buxifolia and Bosea amherstiana dose-dependently reduced abdominal constrictions in mice. Both plants exhibited significant (P < 0.0001) sedative effects in dose of 50, 150 and 150 mg/kg. Both plants markedly (P < 0.0001) reduced yeast induced hyperthermia. The inhibitions were dose-dependent and remained significant up to five hours of administration. These investigational results have linked a pharmacological indication for the traditional claim of the drugs to be used as an anti-inflammatory, analgesics and antipyretic agents. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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  • 中国科学院藻类生物学重点实验室
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  • 中国动物学会原生动物学分会
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  • 中国鱼类学会
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  • 水生生物博物馆
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