| 论文标题： |
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses |
| 作者： |
Feng, Hui; Zhang, Yi-Bing; Gui, Jian-Fang; Lemon, Stanley M.; Yamane, Daisuke |
| 出版刊物： |
PLOS PATHOGENS |
| 出版日期： |
JAN |
| 出版年份： |
2021 |
| 卷/期： |
|
| DOI： |
10.1371/journal.ppat.1009220 |
| 论文摘要： |
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection. |
