论文
论文标题: Cellular and molecular modification of egg envelope hardening in fertilization
作者: Wang, Yeke; Chen, Feng; He, Jun; Xue, Ge; Chen, Jun; Xie, Ping
出版刊物: BIOCHIMIE
出版日期: FEB
出版年份: 2021
卷/期:
DOI: 10.1016/j.biochi.2020.12.007
论文摘要: Fertilization is an essential process that fundamentally impacts fitness. An egg changes dramatically after fertilization mediating the beginning of life, which mainly includes the transformation of the egg envelope via hardening, which is thought to be due to complex reactions involved in the conversion of cellular and molecular. This review highlights the mechanisms of egg envelope hardening in teleost fish. We conclude that the egg envelope hardening might be carried out in two steps. (a) A metalloprotease (alveolin) hydrolyzes the N-terminal proline-glutamine (Pro-Gln) region of zona pellucida (ZP) 1 and (b) triggers intermolecular cross-linking to ZP3 catalyzed by transglutaminase (TGase). The post-fertilization hardening of the egg envelope is an evolutionarily conserved phenomenon across species. We discuss the biochemical function and interaction of some factors reported to be essential to egg envelope hardening in mammalian and nonmammalian species, including metalloprotease, TGase, peroxidase/ovoperoxidase, and other factors (carbohydrate moieties, zinc and Larp6 proteins), and the relevant data suggest that egg envelope hardening is crucial to block polyspermy in internal fertilization, in addition to protecting the developing embryo from mechanical shock and preventing bacterial infection in external fertilization. Increased knowledge of the processes of egg envelope hardening and fertilization is likely to make a remarkable contribution to reproduction and aquaculture. (C) 2020 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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  • 中国科学院藻类生物学重点实验室
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  • 湖北省海洋湖沼学会
  • 中国动物学会原生动物学分会
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  • 中国水产学会鱼病学专业委员会
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  • 水生生物博物馆
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