| 论文标题： |
New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish |
| 作者： |
Lei, Lei; Zhu, Biran; Qiao, Kun; Zhou, Yuxi; Chen, Xiangping; Men, Jun; Yang, Lihua; Wang, Qidong; Han, Jian; Zhou, Bingsheng |
| 出版刊物： |
SCIENCE OF THE TOTAL ENVIRONMENT |
| 出版日期： |
MAY 20 |
| 出版年份： |
2022 |
| 卷/期： |
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| DOI： |
10.1016/j.scitotenv.2022.153623 |
| 论文摘要： |
Deltamethrin, a widely used type II pyrethroid insecticide, was reported with neurotoxicity to aquatic organisms, such as fish. However, the effects and potential mechanisms on the central nervous system remain largely unknown, especially under environmental concentrations. Therefore, we exposed adult female zebrafish to environmentally relevant levels of deltamethrin (30,100, and 333 ng/L) for 21 days to assess neurobehavioral changes related to the central nervous system and explore the modes of action. Behavioral assays revealed significant increases in the swimming speeds, residence time near other fish and the shoaling cohesion in exposed fish. Transcriptomic results enriched the disrupted neural functions involving the glutamatergic and dopaminergic synapses in the brain. The qRT-PCR confirmed the up regulation of the factors for promoting the glutamate release. The measurement of neurotransmitters showed significantly increased content of the excitatory neurotransmitter glutamate in the brain. Taken together, deltamethrin exposure increased the glutamate level and promoted the release of such an excitatory neurotransmitter between the glutamatergic synapses in the brain, which eventually led to hyperactivity of social behaviors in adult zebrafish. |
