| 论文摘要： |
The interaction between nanoparticles (NPs) and pollutants affects their bioavailability and toxicity. However, the processes by which NPs and pollutants change in vivo have rarely been explored. Here, using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), we found that both nanoplastics and ZnO NPs caused more Cd to accumulate in zebrafish larvae, but with distinct pathways. Nanoplastics could adsorb Cd2 + and transfer it into the larvae through the "Trojan horse" effect. The coexposure of nanoplastics and Cd2 + caused Cd to accumulate in the abdomen where the nanoplastics were located without dissociation, showing a lower toxic effect than Cd2 + exposure alone. ZnO NPs weakly adsorbed Cd2 + , but they increased the Zn and Cd contents in larvae by enhancing the expression of metal transporters. The coexposure of ZnO and Cd2 + evenly distributed Cd in the larvae, revealing a more severe toxic effect than Cd2 + exposure alone. Our results demonstrated the changing bioavailability and toxicity of Cd induced by different NPs. This also shows the vital role LA-ICP-MS plays in revealing the relationship between toxicity and bioavailability. In addition, the long-term effect of bioavailability on heavy metal toxicity and nanosafety deserves further investigation. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
