时间：2012年7月4日 星期三 上午10:00
报告专家：Dr. Susan S. Golden（美国科学院院士，加州大学圣地亚哥分校杰出教授）；Dr. James W. Golden（加州大学圣地亚哥分校教授）
报告题目：How cyanobacteria tell time；Cyanobacterial heterocyst development and regulation of nitrogen-fixation genes
Susan Golden received a B.A. (1978) in Biology from Mississippi University for Women and a Ph.D. (1983) in Genetics from the University of Missouri. After postdoctoral research at the University of Chicago, she joined the faculty of Biology at Texas A&M University (1986), where she was promoted to Distinguished Professor in 2003. She joined the Division of Biological Sciences at UCSD in 2008.
During her graduate work she developed genetic tools for the cyanobacterium Synechococcus elongatus (PCC 7942), the first cyanobacterium shown to be subject to genetic transformation. This led to work on regulation of light-responsive photosynthesis gene expression in this organism during her postdoctoral research and at Texas A&M. In the early 1990s she began a collaborative project with C.H. Johnson (Vanderbilt University) and T. Kondo (Nagoya University) that demonstrated circadian rhythms of gene expression in S. elongatus, which is currently the only model organism for a prokaryotic circadian clock. The molecular basis of timekeeping in S. elongatus is now a major focus of her lab. Susan is a member of the Faculty of 1000 Biology, a Fellow of the American Academy of Microbiology, and a Member of the National Academy of Sciences.
Her current research interests are:Circadian Rhythms of Gene Expression in Cyanobacteria;Functional Genomics in S. elongatus; Metabolic Engineering of Cyanobacteria for the production of Biofuels and other Molecules of Interest.
Dr. James W. Golden received a B.S. (1977) in Microbiology from the University of Maryland-College Park and a Ph.D. (1983) in Biology from the University of Missouri-Columbia. After postdoctoral work as an NIH Fellow at The University of Chicago, he joined the Department of Biology at Texas A&M University in 1986. He was promoted to Associate Professor in 1990 and then to Professor in 1996. Dr. Golden moved to the University of California, San Diego in 2008.
He is primarily interested in the developmental biology of bacterial microorganisms with an emphasis on the genetic regulation of cellular differentiation and the cell-to-cell signaling mechanisms that control multicellular pattern formation. His research uses methods of genetics and molecular biology to understand basic principles of regulation and signaling pathways that control development in a simple prokaryotic multicellular organism, the filamentous cyanobacterium Anabaena (Nostoc). It is expected that the basic information gained from studying this model system will be applicable to a variety of other areas including those related to health and the environment. Like all cyanobacteria, Anabaena obtains energy by photosynthesis. Anabaena is also capable of nitrogen fixation, a process that is incompatible with photosynthesis because the nitrogenase enzyme is destroyed by the oxygen produced as a byproduct of photosynthesis. Anabaena solves this problem by spatially separating the two processes into different cell types: photosynthetic vegetative cells and nitrogen-fixing heterocysts. Anabaena grows as a very simple multicellular organism organized as filaments of vegetative cells containing about 10 percent heterocysts. Heterocysts differentiate from vegetative cells at semiregular intervals along the filament and supply fixed nitrogen to neighboring vegetative cells to support their growth.