报告题目：Cyanobacterial biotechnology: strains, genetic tools, crop protection, and nutrient supply
报告人：Prof. James W. Golden,University of California, San Diego，USA
Dr. James W. Golden received a B.S. (1977) in microbiology from the University of Maryland-College Park and a Ph.D. (1983) in Biology from the University of Missouri-Columbia. After postdoctoral work as an NIH Fellow at The University of Chicago, he joined the Department of Biology at Texas A&M University in 1986. He was promoted to Associate Professor in 1990 and then to Professor in 1996. Dr. Golden moved to the University of California, San Diego in 2008.
He is primarily interested in the developmental biology of bacterial microorganisms with an emphasis on the genetic regulation of cellular differentiation and the cell-to-cell signaling mechanisms that control multicellular pattern formation. His research uses methods of genetics and molecular biology to understand basic principles of regulation and signaling pathways that control development in a simple prokaryotic multicellular organism, the filamentous cyanobacterium Anabaena (Nostoc). It is expected that the basic information gained from studying this model system will be applicable to a variety of other areas including those related to health and the environment. Like all cyanobacteria, Anabaena obtains energy by photosynthesis. Anabaena is also capable of nitrogen fixation, a process that is incompatible with photosynthesis because the nitrogenase enzyme is destroyed by the oxygen produced as a byproduct of photosynthesis. Anabaena solves this problem by spatially separating the two processes into different cell types: photosynthetic vegetative cells and nitrogen-fixing heterocysts. Anabaena grows as a very simple multicellular organism organized as filaments of vegetative cells containing about 10 percent heterocysts. Heterocysts differentiate from vegetative cells at semiregular intervals along the filament and supply fixed nitrogen to neighboring vegetative cells to support their growth.