报告专家：Prof. Menfred Schartl University of Wuerzburg, Germany

　　报告题目：Genomic approaches to understand evolution of sex chromosomes in fish

　　时间：2015年10月23日 星期五 上午10：00

　　地点：1号实验楼八楼报告厅

　　专家简介：

　　Appointments and Education

　　Manfred Schartl has studied Chemistry and Biology in Giessen, Germany. After obtaining his doctoral degree in Genetics he worked as scientific assistant in research laboratories in Germany and in the U.S. From 1985 on he was team leader of a research group at the Genetic Center of Max-Planck-Institute for Biochemistry in Martinsried. Since 1991 he has been Head of the Department of Physiological Chemistry at the Biocenter of the University of Wuerzburg. He is vice-chairman of the DFG research center for experimental medicine (Rudolf-Virchow-Zentrum). He was chairman and vice chairman of the Biocenter Wuerzburg between 1996 and 2007. Since 2001 he has been also Adjunct Professor for Experimental Cancer Research at the Institute for Anatomy and Cell Biology at the University of Bergen/Norway. From this University he was awarded an honorary doctoral degree in 2004. He is one of the founders of the study program of Biomedicine in Wuerzburg. He is in the Editorial Board of several international journals and acts as reviewer for several national and international funding organizations and scientific journals.

　　His main research interests are melanoma molecular genetics, gene and genome evolution, fish sex determination and melanoma signal transduction.

　　Publications (selected)

　　Herpin A, Schartl M. Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators. EMBO Rep. 2015, 16(10):1260-74.

　　Schartl M. Sex determination by multiple sex chromosomes in Xenopus tropicalis. Proc Natl Acad Sci USA. 2015, 112(34):10575-6.

　　Chen S, Zhang G,…Schartl M, Tang Q, Wang J. Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle. Nat Genet. 2014, 46(3):253-60.

　　Lampert KP, Blassmann K, ...Schartl M. Single-male paternity in coelacanths. Nat Commun. 2013, 4:2488.

　　Herpin A, Adolfi MC, …Schartl M. Divergent expression regulation of gonad development genes in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex determination. Mol Biol Evol. 2013, 30(10):2328-46.

　　Schartl, M., Walter, R. B., Shen, Y., et al., The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits. Nat Genet 2013, 45, 567-572.