时间：2018年6月27日 星期三 上午10:30

　　地点：3号实验楼 2楼学术报告厅

　　报告专家：Prof. James W. Golden University of California, San Diego

　　报告题目：Broad-host-range genetic tools for cyanobacteria and heterologous expression of natural products

　　专家简介：

　　Dr. James W. Golden received a Ph.D. (1983) in Biology from the University of Missouri-Columbia. After postdoctoral work as an NIH Fellow at The University of Chicago, he joined the Department of Biology at Texas A&M University in 1986. He was promoted to Associate Professor in 1990 and then to Professor in 1996. Dr. Golden moved to the University of California, San Diego in 2008.

　　The research direction of James W Golden is Genetics and molecular biology of cyanobacteria with emphasis on biosynthetic genes for natural products and development of genetic tools for biotechnology applications.

　　代表性文章：

　　1.Taton A, Ma AT, Ota M, Golden SS, Golden JW. 2017. NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria. ACS Synth Biol doi:10.1021/acssynbio.7b00203.

　　2.Chen, Y., A. Taton, M. Go, R. E. London, L. M. Pieper, S. S. Golden, and J. W. Golden. 2016. Self-replicating shuttle vectors based on pANS, a small endogenous plasmid of the unicellular cyanobacterium Synechococcus elongatus PCC 7942. Microbiology 162(12):2029-2041.

　　3.Ma, A.T., Schmidt, C. M., and Golden, J.W. (2014) Regulation of gene expression in diverse cyanobacterial species by using theophylline-responsive riboswitches. Appl Environ Microbiol 80: 6704-6713.

　　4.Taton, A., F. Unglaub, N. E. Wright, W. Y. Zeng, J. Paz-Yepes, B. Brahamsha, B. Palenik, T. C. Peterson, F. Haerizadeh, S. S. Golden, and J. W. Golden. 2014. Broad-host-range vector system for synthetic biology and biotechnology in cyanobacteria. Nucleic Acids Res. 42: e136.

　　5.Khudyakov, I.Y., and Golden, J.W. (2004) Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation. Proc Natl Acad Sci U S A 101: 16040-16045.

　　6.Yoon, H.S., and Golden, J.W. (1998) Heterocyst pattern formation controlled by a diffusible peptide. Science 282: 935-938.