鱼类分子内分泌学研究组
学科带头人:翟刚 项目研究员 学科组成员:贺江燕副研究员、娄气永副研究员,金霞实验师 目前主要以斑马鱼为主要研究模式,并结合鲫鱼为养殖模式,集中关注鱼类的内分泌生长调控轴、在鱼类营养、代谢、生长、繁殖等方面的内分泌调控研究方面,开展了较为系统地研究工作。并在采用转基因技术对鱼类的肌肉生长、可控性鱼类性腺发育技术研究等方面也正在取得许多深具潜力的研究进展。对利用斑马鱼为模式生物系统的环境内分泌干扰物评价体内模式进行了一系列有益的探索。 代表论文: |
1. Gao Y,Dai Z,Shi C,Zhai G,Jin X,He J,Lou Q and Yin Z* (2016) Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh Front. Endocrinol. 7:88. doi: 10.3389/fendo.2016.00088.
2. Gang Zhai,Tingting Shu,Yuguo Xia,Xia Jin,Jiangyan He and Zhan Yin* (2016)Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A Science Bulletin(In Press).
3. Yuqin Shu,Qiyong Lou,Ziru Dai,Xiangyan Dai,Jiangyan He,Wei Hu & Zhan Yin * 2016 The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models Scientific Reports 6,Article number: 18597 (2016)
4. Dai Z,Wang H,Jin X,Wang H,He J,Liu M,Yin Z,Sun Y,Lou Q. 2015 Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E849-59. doi: 10.1152/ajpendo.00540.2014. Epub 2015 Mar 10.
5. Dai X,Jin X,Chen X,He J, Yin Z*. 2015 Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824. doi: 10.1371/journal.pone.0117824. eCollection 2015.
6. Dai X,Zhang W,Zhuo Z,He J, Yin Z*. (2015) Neuroendocrine regulation of somatic growth in fishes. Sci China Life Sci. 2015 Feb;58(2):137-47. doi: 10.1007/s11427-015-4805-8. Epub 2015 Feb 7. Review.
7. Cheng X,Chen X,Li D,Jin X,He J, Yin Z* 2015 .Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. Gen Comp Endocrinol. 2015 Apr 1;214:87-94. doi: 10.1016/j.ygcen.2014.05.029. Epub 2014 Jun 4.
8. Cheng,X.,Chen,X.,Jin,X.,He,J., Yin,Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278: 78–84
9. He,W.,Dai,X.,Chen,X.,He,J., Yin,Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221 (3) 429-440 。
10. Li,D.,Lou,Q.,Zhai,G.,Peng,X.,Cheng,X.,Dai,X.,Zhuo,Z.,Shang,G.,Jin,X.,Chen,X.,Han,D.,He,J., Yin,Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155(6):2199–221.
11. Zhai,G.,Gu,Q.,He,J.,Lou,Q.,Chen,X.,Jin,X.,Bi,E., Yin,Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle,pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7):1310-1321.
12. Mei Y,Yin N,Jin X,He J, Yin Z* 2013 The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9.
13. Chen D,Li L,Tu X,Yin Z*,Wang Q.2013 Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Hum Mol Genet. 22(5):963-76.
14. Cui X, Zhang J, Du R, Wang L, Archacki S, Zhang Y, Yuan M, Ke T, Li H, Li D, Li C, Li DW, Tang Z, Yin Z*,Liu M. (2012) HSF4 is involved in DNA damage repair through regulation of Rad51.Biochim Biophys Acta. 1822(8):1308-15.
15. Ji C.,Jin X.,He J.& Yin,Z*. 2012 Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicol. Appl. Pharmacol. 262(2):149-155
16. Jiang N.,Jin X.,He J. & Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation Biol Reprod 87 (3) 54,1-8
17. Chen X.,Lou Q.,He J. & Yin Z*. 2012 Role of Zebrafish Lbx2 in Embryonic Lateral Line Development . PLoS ONE 6(12):e29515.
18. Lou Q.,He J.,Hu L.& Yin Z*. 2012 Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish。 Biochim Biophys Acta. 823(5):1024-32
19. Li X.,He J.,Hu W & Yin Z * 2009 The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology 150(6):2767-74
20. Ma L.,Li D.,Wang J.,He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus)。 Aquatic Toxicol. 91 (1):19-25.
21. Trivedi CM*,Luo Y*,Yin Z*,Zhang M,Zhu W,Wang T,Floss T,Goettlicher M,Noppinger PR,Wurst W,Ferrari VA,Abrams CS,Gruber PJ,Epstein JA. (2007). HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3?. Nature Medcine. 13(3):324-331. (Equal first author).
22. Yin,Z. Haynie,J.,Yang,X.,.Han,B.,Kiatchoosakun,S.,Restivo,J.,Yuan,S.,Prabhakar,N. R.,Herrup,K.,Conlon,R. A.,Hoit,B. D.,Watanabe,M and Yu-Chung Yang. 2002 The essential role of Cited2,a negative regulator hif-1 in heart development and neurulation. PNAS 99,10488-10493.
Last updated on Oct..18,2016