学科组成员：孙玉华 研究员；助理研究员孙晓云，在读博士4人，在读硕士2人。  　　

  学科组介绍： 

　　本学科组关注基础研究和应用基础研究。一方面研究生命科学的基本问题，即受精卵如何发育成为一个完整的个体？另一方面，围绕基础科研服务于国家需求，从干细胞理论和技术出发，研究重大疾病的发病机理、开展干细胞治疗研究。本课题组以斑马鱼和哺乳动物多能干细胞为材料，在以下方向开展研究：脊椎动物早期胚胎发育、多能干细胞自我更新和分化机理、干细胞治疗和转化医学等。主要研究内容如下： 

　　1、以斑马鱼为模式生物，研究转录因子、信号通路、表观遗传因子以及染色质高级结构等调控脊椎动物早期胚胎发育、细胞命运决定以及基因表达的分子机制。为治疗人类发育疾病提供机理解释。 

　　2、以人和小鼠多能干细胞为材料，揭示干细胞自我更新与维持、分化的细胞及分子生物学基础。鉴定调控干细胞自我更新和分化的关键因子；阐明其在干细胞自我更新和分化、细胞命运决定中的作用机制。 

　　3、干细胞治疗和转化医学研究。研究内容包括：干细胞理论和技术研究重大疾病发病机理；基于多能干细胞的体外类器官（类肠、类心脏等）构建，阐明其定向分化及自组装规律；干细胞和组织工程结合研发新型临床替代物等等。  

　　本课题组得到国家重点研发计划项目资助，总研究经费约600万元。 

   近年来发表文章：

　　Sun, X., Peng, X., Cao, Y., Zhou, Y., and Sun, Y. (2020). ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling. Nat Commun 11, 2984. 

　　Sun, X.Y.; Yu, W.J.; Li, L.; Sun, Y.H. (2020): ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4. Frontiers in cell and developmental biology . 

   Sun, X.Y., Chen, J., Zhang, Y.Y., Munisha, M., Dougan, S., and Sun, Y.H. (2018). Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish. Frontiers in cell and developmental biology 6.  

　　Ryan Berger, Yuhua Sun et al., (2016). ST8SIA4-dependent polysialylation is part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells, DOI: 10.1002/stem.2379 　　  

　　Amar Singh*, Yuhua Sun*, Li Li, Steve Qin, and Steve Dalton (2015). Cell-Cycle  Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports，3:323 (*equal contribution) 　　  

　　Yuhua Sun, Weichia Tseng, Rebecca Ball,and Scott Dougan (2014). Extra-embryonic signals under the control of Mga, Max and Smad4 are required for dorsoventral patterning. Developmental Cell, 28: 322 　　  

　　J Champell*, YH Sun*, A Singh, S Dalton (2013). Myc/Max control Erk signaling and pluripotency by regulation of dual specificity phosphatases 2 and 7. Genes & Development (*equal contribution), 27:725-733 　　  

　　J Phillips-Cremins, M Sauria, A Sanyal, T Gerasimova, B Lajoie, J Bell, CT Ong, T Hookway, C Guo, YH Sun, M Bland, W Wagstaff, S Dalton, T McDevitt, R Sen, J Dekker, J Taylor, V Corces (2013)．Architectural protein subclasses shape 3- D organization of genomes during lineage commitment．Cell, 153: 1281 　　  

　　Amar M. Singh, David Reynoids, Timothy Cliff, Satoshi Ohtsuka, Alexa Mattheyses, Yuhua Sun, Laura Menendez, Michael Kulik and Stephen Dalton (2012). Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation. Cell stem cell, 10(3): 312-326 　　  

　　Sun YH, Wloga D. and Dougan S. (2011). Embryological manipulations in zebrafish. Methods Mol. Biol., 770: 139-184 　　  

　　D.M. Webster, C.F. Teo, YH. Sun, D. Wloga, S. Gay, L. Wells and S. T. Dougan (2009). O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev. Biol., 9(1): 28-33 Highly Accessed Article 　　  

　　Chengtai Yang, Ling Cao, Weimin Wang, Yi Yang, Binlun Yan, Li Su, Yuhua Sun, and Huanling Wang (2009). Comparative and evolutionary analysis in natural diploid and tetraploid weather loach Misgurnus anguillicaudatus based on cytochrome b sequence data in central China. Environmental Biology of Fishes, 86(1): 145-153 　　  

　　Treer T., Sprem N, Torcu-Koc, YH Sun, and M. Piria (2008). Length-weight relationship of freshwater fishes of Croatia. J. Appl. Ichthyol, 24: 626-628 　　  

　　Yuhua Sun, Rong Tang, Dapeng Li, Xuezhen Zhang, Juan Fu, Ping Xie (2008). Acute effects of microcystins on transcription of antioxidant enzyme genes in crucian carp. Environ. Toxicol., 23: 145-152  　　  

　　Zexia Gao, *Weimin Wang, Khalid Abbas, Xiaoyun Zhou, Yi Yang, James S Diana, Hanping Wang, Huanling Wang, Yang Li, Yuhua Sun (2007). Haematological characterization of loach Misgurnus anguillicaudatus: comparison among diploid, triploid and tetraploid specimens. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147- 　　  

　　YH Sun, CX Xie, WM Wang, SY Liu, T. Treer, MM Chang et al (2007). The genetic variation and the biogeography of catostomid fishes based on mitochondrial and nucleic DNA sequences. Journal of Fish Biology, 70: 291-309  　　  

　　Yuhua Sun, Siyang Liu, Gang Zhao, QX Yu et al (2004). Population structure of Chinese sucker Myxocyprinus asiatus (Cypriniformes: Catostomidae) in the Yangtze River based on Mitochondrial DNA control region sequences. Fisheries Science, 70(3): 412-420 　　  

　　SUN Yu-Hua; WANG Wei; LIU Si-Yang; HE Shun-Ping; SHAO Xue-Ling; XIE Zhi-Xiong; DENG Feng-Jiao; LIU Yong; TONG Jin-Gou; WU Qing-Jiang (2002). Genetic Diversity Analysis of Mitochondrial D-loop Region of Chinese Sucker (Myxocyprinus asiaticus). Journal of Genetics and Genomics (in Chinese), 29(9): 787-790