中国科学院水生生物研究所研究员，博士。1991年毕业于湖北大学生物系；1996年获中国科学院水生生物研究所硕士学位；2003年获中国科学院研究生院理学博士学位，同年获中国科学院院长特别奖。2007年12月至2008年11月在美国德州大学MD Anderson Cancer Center免疫学系做访问研究。1996年进入中国科学院水生生物研究所工作，主要聚焦鱼类响应病毒感染的天然免疫分子机理及鱼类抗病毒育种探索研究。致力于挖掘鱼类响应病毒感染的相关基因，解析相关基因的功能、调控机制及信号通路，发现特异于鱼类物种的抗病毒感染免疫规律，尤其是鱼类干扰素介导的天然抗病毒免疫反应的分子机理。鉴定潜在应用于鱼类抗病育种实践的关键分子，探索鱼类抗病新途径和新方法，创制鱼类抗病毒新种质和新材料。

1. Qu ZL, Gong XY, An LL, Sun HY, Guo WH, Luan HY, Wu MY, Dan C, Gui JF, Zhang YB^*. Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience, 2024, 27(4):109497.
2. Qu ZL, Zhang YB^*. Protocol for linking enhanced interferon immunity to virus resistance in gene-knockout zebrafish. STAR Protocols. 2024, 5(3):103156.
3. Zhao X, An L-L, Gong X-Y, Dan C, Qu Z-L, Sun H-Y, Guo W-H, Gui J-F, Zhang Y-B^*. A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING. Journal of Virology. 2024,98(2):e0180123.
4. 郭文浩, 丹成, 梅洁，张义兵^*. 黄颡鱼FTR67基因的克隆及功能研究. 水生生物学报, 2023, 47(5): 747-755.
5. Li YL, Gong XY, Qu ZL, Zhao X, Dan C, Sun HY, An LL, Gui JF, Zhang YB^*. Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Science. 2023, 24(5):4592.
6. Guo WH, Dan C, Gong XY, Li YL, Sun HY, Qu ZL, An LL, Zhao X, Mei J, Gui JF, Zhang YB^*. A finTRIM member 100 (FTR100) is unique to Otomorpha fish for constitutive regulation of IFN response. Water Biology and Security. 2023, 2(2):100137.
7. Zhao X, Dan C, Gong XY, Li YL, Qu ZL, Sun HY, An LL, Guo WH, Mei J, Gui JF, Zhang YB^*. Yellow catfish RIO kinases (RIOKs) negatively regulate fish interferon-mediated antiviral response. Dev Comp Immunol. 2023,142:104656.
8. Gong XY, Zhang YB^*. A protocol to characterize zebrafish LGP2 as a dual regulator of IFN response during viral infection. STAR Protocols. 2022,3(4), 101844.
9. Qu ZL, Li YL, Gong XY, Zhao X, Sun HY, Dan C, Gui JF, Zhang YB^*. A finTRIM family protein acquires RNA-binding activity and E3 ligase activity to shape IFN response in fish. Journal of Immunology. 2022, 209 (7):1335-1347
10. Gong XY, Qu ZL, Li YL, Sun HY, Zhao X, Dan C, Gui JF, Zhang YB^*. Function conservation and disparities of zebrafish and human LGP2 genes in fish and mammalian cells responsive to poly(I:C). Front. Immunol. 2022,13:985792.
11. Gong XY, Zhang QM, Zhao X, Li YL, Qu ZL, Li Z, Dan C, Gui JF, Zhang YB^*. LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 2022, 25:104821.
12. Zhao X, Dan C, Gong XY, Li YL, Qu ZL, Sun HY, An LL, Guo WH, Gui JF, Zhang YB^*. Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Dev Comp Immunol. 2022,135:104485.
13. An LL, Zhao X, Gong XY, Li YL, Qu ZL, Sun HY, Guo WH, Dan C, Gui JF, Zhang YB^*. Promoter binding and nuclear retention features of zebrafish IRF family members in IFN response. Front. Immunol. 2022, 13:861262.
14. Li YL, Gong XY, Qu ZL, Zhao X, Dan C, Gui JF, Zhang YB^*. A novel non-mammalian-specific HERC7 negatively regulates IFN response through degrading RLR signaling factors. Journal of Immunology. 2022, 208 (5): 1189-1203.
15. 赵祥，张义兵^*。鱼类IRF家族在干扰素抗病毒免疫反应中的调控功能。水产学报，2021, 45(9):1592-1604.
16. Feng H, Zhang YB, Gui JF, Lemon SM, Yamane D. Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses. PLoS Pathog. 2021, 17(1):e1009220.
17. Zhao X, Gong XY, Li YL, Dan C, Gui JF, Zhang YB^*. Characterization of DNA binding and nuclear retention identifies zebrafish-specific IRF11 as a positive regulator of IFN antiviral response. Journal of Immunology. 2020, 205 (1):237-250
18. Wu CX, Zhang YB^* and Hu CY^*. PKZ, a Fish-Unique eIF2 Kinase Involved in Innate Immune Response. Front. Immunol. 2020,11:585.
19. Xiong Y, Dan C, Ren F, Su Z, Zhang YB^*, Mei J^*. Proteomic profiling of yellow catfish (Pelteobagrus fulvidraco) skin mucus identifies differentially-expressed proteins in response to Edwardsiella ictaluri infection. Fish Shellfish Immunol. 2020;100:98-108.
20. Zang ZX, Dan C, Zhou L, Zhang QY, Gui JF, Zhang YB^*. Function characterization and expression regulation of two different-sized 3’untranslated region-containing interferon genes from clone F of gibel carp Carassius auratus gibelio. Molecular Immunology, 2020,119:18–26.
21. Song W, Zhang YB, Zhang XJ, Gui, JF. De Novo Transcriptome Assembly of Four Organs of Collichthys Lucidus and Identification of Genes Involved in Sex Determination and Reproduction. PLoS One. 2020 Mar 27;15(3):e0230580.
22. Wu M, Dan C, Gui JF, Zhang YB^*. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription. Fish & Shellfish Immunology, 2019;90:180-187.
23. Wu M, Zhao X, Gong XY, Wang Y, Gui JF, Zhang YB^*. FTRCA1, a species-specific member of finTRIM family, negatively regulates fish interferon response through autophage-lysosomal degradation of TBK1. Journal of Immunology, 2019, 202 (8):  2407-2420
24. Gong XY, Zhang QM, Gui JF, Zhang YB^*. SVCV infection triggers fish IFN response through RLR signaling pathway. Fish & Shellfish Immunology, 2019, 86:1058-1063
25. Zhang QM, Zhao X, Li Z, Wu M, Gui JF, Zhang YB^*. Alternative splicing transcripts of zebrafish LGP2 gene differentially contributes to interferon antiviral response. Journal of Immunology, 2018, 200 (2):  688-703
26. Gao FX, Lu WJ, Wang Y, Zhang QY, Zhang YB, Mou CY, Li Z, Zhang XJ, Liu CW, Zhou L, Gui JF. Differential expression and functional diversification of diverse immunoglobulin domain-containing protein (DICP) family in three gynogenetic clones of gibel carp. Dev Comp Immunol. 2018;84:396-407.
27. Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity. Cell Rep. 2017;21(1):195-207.
28. 熊亚玮，张义兵^*，桂建芳。斑马鱼IRF11基因的鉴定、亚细胞定位及表达特征。水生生物学报，2017 , 41 (1) :1-8。
29. Feng H, Zhang QM, Zhang YB^*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3, and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes. Journal of Immunology, 2016, 197(5):1893-904.
30. Chen C, Zhang YB^*, Gui JF. Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes. Dev Comp Immunol, 2015, 52:112–122。31.  Feng H, Zhang YB^*, Zhang QM, Li Z, Zhang QY, Gui JF^*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNj1 and IFNj3 promoters downstream of MyD88 signaling. Journal of Immunology, 2015, 194: 1225–1238.