鱼类发育遗传学与细胞工程学研究组
研究组组长：桂建芳 院士( GUI Jianfang,jfgui@ihb.ac.cn)
研究组成员：
桂建芳（院士、研究员）、周莉（研究员）、王忠卫（研究员）、李熙银（研究员）、鲁蒙（副研究员）、余鹏（副研究员）、李志（高级实验师）、张晓娟（项目高级实验师）、丁苗（博士后研究助理）、林桥洪（博士后研究助理）、王明涛（博士后研究助理）、周于琳（博士后研究助理）、博士研究生16名、硕士研究生16名。
研究组介绍：
本团队现得到国家重点研发计划、国家自然科学基金重点项目和面上项目、现代农业产业技术体系、中国科学院战略性科技先导专项、国家重点实验室自主研究项目等支持。研究工作主要集中在三个方面，一是进行鱼类重要经济性状的遗传基础解析，重点关注银鲫配子发生和雌核生殖、性别决定和分化、免疫和抗病以及金鱼形态变异机制等，由此发展精育种技术，如基于全基因组分型选择、基因组融合重构、基因编辑、和性控育种等；二是进行多倍体鱼类基因组融合重构研究，由此揭示基因组或亚基因组整入的遗传机制，开拓多倍体合成和不育种质创制的技术路径；三是开展可持续水产养殖的新品种培育和推广示范研究。
近期研究关键词：
鱼类精准育种、新多倍体合成、基因组及基因组重构、基因编辑
近三年主要代表作:
1. Gui JF*. Chinese wisdom and modern innovation of aquaculture. Water Biology and Security,2024,100271.https://doi.org/10.1016/j.watbs.2024.100271.
2. Lu M,Zhou L*,Gui JF*. Evolutionary mechanisms and practical significance of reproductive success and clonal diversity in unisexual vertebrate polyploids. Science China Life Sciences,2024,67,449-459. https://doi.org/10.1007/s11427-023-2486-2.
3. Lu M,Zhang QC,Zhu ZY,Peng F,Li Z,Wang Y,Li XY,Wang ZW,Zhang XJ,Zhou L*,Gui JF*. An efficient approach to synthesize sterile allopolyploids through the combined reproduction mode of ameiotic oogenesis and sperm-egg fusion in the polyploid Carassius complex. Science Bulletin,2023, 68(10):1038-1050. https://doi.org/10.1016/j.scib.2023.04.029.
4.
Gan RH,Li Z,Wang ZW,Li XY,Wang Y,Zhang XJ,Tong JF,Wu Y,Xia LY,Gao ZX*,Zhou L*,Gui JF*. Creation of intermuscular bone-free mutants in amphitriploid gibel carp by editing two duplicated runx2b homeologs. Aquaculture, 2023,567: 7393. https://doi.org/10.1016/j.aquaculture.2023.739300.
5. Gong GR,Xiong Y,Xiao S,Li XY,Huang PP,Liao QH,Han Q,Lin Q,Dan C,Zhou L,Ren F,Zhou Q,Gui JF*,Mei J*. Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity. National Science Review,2023,10(2):nwac239. https://doi.org/10.1093/nsr/nwac239.
6.
Yu P,Wang Y,Li Z,Jin H,Li LL,Han X,Wang ZW,Yang XL,Li XY,Zhang XJ,Zhou L*,Gui JF*.Causal gene identification and desirable trait recreation in goldfish. Science China Life Sciences,2022,65(12):2341-2353. https://doi.org/10.1007/s11427-022-2194-7.
7. Lu M,Li Z,Zhu ZY,Peng F,Wang Y,Li XY,Wang ZW,Zhang XJ,Zhou L*,Gui JF*. Changes in ploidy drive reproduction transition and genomic diversity in a polyploid fish complex. Molecular Biology and Evolution,2022,39(9):msac 188. https://doi.org/10.1093/molbev/msac188.
8. Wang Y,Li XY,Xu W
J,Wang K,Wu B, Xu M, Chen Y, Miao LJ, Wang ZW, Li Z, Zhang XJ, Yin Z, Zhou BT, Yang YL, Zhu CL, Hu ML, Zheng JM, Feng CG, Qiu Q, Tian LT, Lu M, Peng F, Lu WJ, Tong JF, Tong JG, Fu BD, Yu P, Ding M, Gan RH, Zhang QQ, Jian JB, Zhang C, He WM, Yang W, Zhao ZC, Zhang QQ, Gao Q, Xu JY, Bai MZ, Zhang YP, Yang HM, Fang XD*, Wang W*, Zhou L*, Gui JF*. 2022. Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish. Nature Ecology & Evolution, 2022, 6, 1354-1366. https://doi.org/10.1038/s41559-022-01813-z.
9. Lu LF,Jiang JY,Du WX,Wang XL,Li ZC,Zhou XY,Zhang C,Mou CY,Chen DD,Li Z,Zhou L,Gui JF,Li XY*,Li S*. 2022. Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLOS Pathogens,18: e1010626. https://doi.org/10.1371/journal.ppat.1010626.
10.
Wang MT,Li Z,Ding M,Yao TZ,Yang S,Zhang XJ,Miao C,Du WX,Shi Q,Li S,Mei J,Wang Y,Wang ZW,Zhou L,Li XY*,Gui JF*. Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish. PLOS Genetics,2022,18(6):e1010288. https://doi.org/10.1371/journal.pgen.1010288.
